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Datasets/PDC000272

CPTAC PDA Discovery Study

OpenMachine-extracted
Clinical Proteomic Tumor Analysis ConsortiumAvailable from PDC
Can it answer my research question?Who has used itGet the data

Can it answer your research question?

4 of 6 supported

  • Overall survival

    Supported

    Vital status and time are populated; median follow-up 1.3 years; 144 cases with follow-up; endpoints: overall survival, recurrence-free interval.API

  • Progression or recurrence

    Supported

    A time to event is derivable: recurrence-free interval; progression_or_recurrence is informative for 0% of cases.API

  • Treatment response

    Not supported

    treatment_outcome is populated for no case in the harmonized records.API

  • Which drug was given

    Not supported

    therapeutic_agents is recorded for no case in the harmonized records.API

  • Stage-adjusted modelling

    Supported

    ajcc_pathologic_stage is informative for 85% of cases.API

  • Analysis by race or ethnicity

    Supported

    Race is informative for 90% of cases.API

Judged from the repository’s own field completeness (thresholds). “Not measured” means we have not probed that field for this record, not that the data lack it.

At a glance

Every percentage is the repository’s own record of what is filled in
CasesAPI
166
Measurement types
3
Follow-upAPI
15.0 months
for 144 of 166 cases; overall survival, recurrence-free interval
Treatment responseAPI
Not recorded

SubjectCALC

Pancreas

As filed by the repository

Pancreatic Ductal AdenocarcinomaPancreas

Who is in the cohortAPI

A usable value“Not reported” or “unknown”No value recorded
  • Sex85 male · 68 female · 13 not reported
  • Race91 white · 34 other · 23 asian · 2 1 other · 14 not reported · 2 Unknown
  • Ethnicity31 not hispanic or latino · 1 hispanic or latino · 128 not reported · 6 Unknown
  • Vital status115 Dead · 29 Alive · 9 Not Reported · 13 no value recorded

What was measured, and on how many

3 measurement types, 3 covering the whole cohort.

  • Glycoproteome mass spectrometry (TMT11 / DDA)scarce166 of 166 · 100%
  • Phosphoproteome mass spectrometry (TMT11 / DDA)166 of 166 · 100%
  • Proteome mass spectrometry (TMT11 / DDA)166 of 166 · 100%
  • Proteome mass spectrometry (Label Free / DIA)105 of 166 · 63%
Platform, files and data levels
AssayPlatformFilesLevels
Glycoproteome mass spectrometry (TMT11 / DDA)APITMT11-raw, peptide/protein matrix
Phosphoproteome mass spectrometry (TMT11 / DDA)APITMT11-raw, peptide/protein matrix
Proteome mass spectrometry (TMT11 / DDA)APITMT11-raw, peptide/protein matrix
Proteome mass spectrometry (Label Free / DIA)APILabel Free-raw, peptide/protein matrix
How complete all 27 clinical fields are - 10 informative for at least 80% of cases

A field counts as informative only when it holds a real value. “Not reported” blocks an analysis just as a missing field does. Fields marked 1:n can hold several records per case, so they show the share of cases with any record.

Informative - a usable valuePresent but uninformative - “not reported” or “unknown”Absent - no value recorded

Outcome

  • Vital statusAPI87%
  • Days to deathAPI69%
  • Cause of deathAPI55%
  • Days to recurrenceAPI19%
  • Progression or recurrenceAPI0%
  • Last known disease statusAPI0%

Follow-up

  • Days to last follow-upAPI87%

Treatment

  • Prior treatmentAPI0%
  • Treatment typeAPI0%
  • Therapeutic agentsAPI0%
  • Treatment outcomeAPI0%
  • Regimen or line of therapyAPI0%
  • Treatment givenAPI0%

Staging

  • AJCC pathologic stageAPI85%
  • AJCC clinical stageAPI0%
  • AJCC pathologic stage (tumor_stage)API0%

Diagnosis

  • Primary diagnosisAPI88%
  • Tissue or organ of originAPI88%
  • Prior malignancyAPI0%
  • Synchronous malignancyAPI0%

Pathology

  • Morphology (ICD-O)API88%
  • Tumor gradeAPI88%
  • Classification of tumorAPI0%

Demographics

  • Sex at birth (gender)API92%
  • RaceAPI90%
  • Age at diagnosisAPI87%
  • EthnicityAPI19%

Access

OpenDownload without an account.API

Direct download from the PDC portal or its API; no account required

Open components
4 analytical fraction studies
License
Open access under the PDC data use terms
Citation requirement
Cite the PDC study identifier and the study's primary publication; PDC asks that the consortium be acknowledged.

What it is good for

Written and checked by a reviewer, not generated from metadata.

No reviewed research questions yet. The measurements and field completeness above are machine-extracted and still useful for judging fit.

What it cannot tell you

Written by a reviewer against the source, not inferred from what is missing.

No reviewed limitations yet. Check the field completeness chart above before committing to an analysis. Low coverage on an endpoint you need is the most common blocker.

Who has used it

Articles that analyzed these data, counted separately from articles that only cited the paper. Only the first counts as reuse.

Analyzed the dataCALC2
19
accession in the methods section
Declared using it
7
named in a data availability statement
Cited the paper
-
attention to the publication, not reuse of the data
Against expectation
Somewhat below
about 20 articles expected; index -0.06

What articles did with it

Only the last row counts as reuse. Where the accession appears in an article tells us what the authors did with the data.

  • Mentioned the dataset1
  • Accession found in text0
  • Declared using it7
  • Analyzed the data19

Against comparable datasets

19 articles analyzed these data. About 20 would be expected. The expectation comes from a model of size, age, breadth and access tier.

  • Analyzed it19
  • Expected~20
Reuse assessment
  • Reuse is within the expected range for comparable datasets (index -0.06).

Compared against 132 datasets in this corpus with a citable accession and sufficient metadata. See Methods for the model.

Articles that analyzed the data

Examples, not the full list. 25 articles matching this dataset's accession search were retrieved and graded individually; these are the strongest of those.

Deep-review sample: author overlap and funding were checked only for the 10 articles listed here, not for every article examined. Of the 10 that analyzed the data, author overlap with the generating team could not be checked for any of them, and 1 of the 10 we could check were themselves NCI-funded. These are sample counts, not population estimates.

Community examples

Share your example

Analyses someone ran on these data end to end, each with a receipt recording when it ran, against which packages and for how long.

Nobody has shared an analysis of this dataset yet. The examples on other datasets cover the common patterns and can be adapted - and if you adapt one, it belongs here.

Start here

Starter code generated from this record’s own identifiers, then the access steps.

Get the data in code

PDC: file manifest through the GraphQL APIpython

This cohort spans 4 PDC studies (PDC000272, PDC000271, PDC000270, PDC000341). Repeat for each.

import requests

PDC_STUDY = "PDC000272"
API = "https://proteomic.datacommons.cancer.gov/graphql"

def gql(query, **variables):
    r = requests.post(API, json={"query": query, "variables": variables}, timeout=180)
    r.raise_for_status()
    body = r.json()
    if body.get("errors"):
        raise RuntimeError(body["errors"][0]["message"])
    return body["data"]

# filesPerStudy only fills its fields when given the study UUID: called with the
# pdc_study_id it returns the right number of rows with every column null.
study = gql("""query ($id: String!) {
  study(pdc_study_id: $id acceptDUA: true) { study_id study_name }
}""", id=PDC_STUDY)["study"][0]

files = gql("""query ($sid: String!) {
  filesPerStudy(study_id: $sid acceptDUA: true) {
    file_id file_name file_type data_category md5sum file_size signedUrl { url }
  }
}""", sid=study["study_id"])["filesPerStudy"]

print(study["study_name"], "-", len(files), "files")
for f in files[:3]:
    print(f["file_name"], f["data_category"], f["file_size"])
# Each signedUrl.url is a time-limited download link; stream it to disk with requests.get(url, stream=True).
This page as data: limitations firstbash
curl -s https://cd2s.vercel.app/data/datasets/pdc-cptac-pda-discovery-study.json | python3 -c '
import json, sys
r = json.load(sys.stdin)
for l in r["limitations"]:
    print(l["severity"].upper(), "-", l["statement"][:120])
print("survival endpoint:", r["longitudinal"]["has_survival_endpoint"], "| treatment response:", r["longitudinal"]["has_treatment_response"])'

Access steps

  1. 1
    Open the study in the PDC portalFor people5 minutes

    Proteomic data are released open; the portal's use guidelines still apply. This record spans 4 PDC studies; repeat for each.

    https://pdc.cancer.gov/pdc/study/PDC000272

    Generated from repository policy. Check the linked policy before downloading.

  2. 2
    Accept the data use guidelines and downloadFor peopleminutes to hours, by study size

    The portal asks for acknowledgement and citation, not a data access request.

    https://pdc.cancer.gov/pdc/data-use-guidelines

    Generated from repository policy. Check the linked policy before downloading.

  3. 3
    Resolve the study UUID, then fetch the file manifestFor agents

    filesPerStudy keys on the study UUID, not on PDC000272: called with the pdc_study_id it returns the right number of rows with every column null. Resolve the UUID first and pass the terms acknowledgement.

    python - <<'PY'
import requests
API = "https://proteomic.datacommons.cancer.gov/graphql"

def gql(query, **variables):
    r = requests.post(API, json={"query": query, "variables": variables}, timeout=180)
    r.raise_for_status()
    body = r.json()
    if body.get("errors"):
        raise RuntimeError(body["errors"][0]["message"])
    return body["data"]

study = gql('query($id:String!){ study(pdc_study_id:$id acceptDUA:true){ study_id } }',
            id="PDC000272")["study"][0]
files = gql('query($sid:String!){ filesPerStudy(study_id:$sid acceptDUA:true)'
            '{ file_id file_name file_size } }', sid=study["study_id"])["filesPerStudy"]
print(len(files), "files")
PY
    https://pdc.cancer.gov/data-dictionary/publicapi-documentation/

    Generated from repository policy. Check the linked policy before downloading.

Provenance

All of it, and more, is in this record’s JSON.

Identifiers

Versions and verification

Released
1 Jan 2022
Metadata retrieved
18 Sept 2026
Review status
Machine-extracted
Data generation funding
Funded data generation

Funding

Awards resolved through NIH RePORTER. Awards that paid to generate these data are listed apart from awards that paid to reuse them. Both are returns on NCI investment, but different ones.

Funded reuse of these data

  • R50CA211462Critical Resources Provided by UNMC Rapid Autopsy Program (RAP) Biorepository Stimulate Cancer ResearchPaul M GrandgenettFY2016-2026API
  • R44CA235991Targeting LIF/LIFR in pancreatic cancerSushil Kumar, Hareesh B NairFY2019-2021API
  • R01CA247471Modulation of Tumor Microenvironment for Improved Therapy of Pancreatic CancerSurinder K. Batra, MANEESH JAINFY2020-2024API
  • R01CA210637Role of PD2/Paf1 in Pancreatic Acinar to Ductal MetaplasiaSurinder K. Batra, Moorthy P. PonnusamyFY2017-2021API
  • R01CA206444Rac1 GTPase in tumorigenesis and progression of pancreatic cancerSurinder K. Batra, MICHEL M OUELLETTEFY2016-2020API
  • R01CA183459Targeting Mucin and EGFR Axis in Pancreatic CancerSurinder K. BatraFY2014-2018API

Funded infrastructure or harmonization

  • U01CA200466Validation of biomarkers for risk prediction and early diagnosis of Pancreatic AdenocarcinomaSurinder K. Batra, Randall BrandFY2016-2026API
  • P01CA217798Pancreatic Cancer MetastasisSurinder K. Batra, MANEESH JAINFY2018-2022API

For softwarerecord JSON