{"id":"pdc-pediatric-brain-cancer-pilot-study","title":"Pediatric Brain Cancer Pilot Study","short_title":"PDC000176","aliases":["Pediatric Brain Cancer Pilot Study - Phosphoproteome","Pediatric Brain Cancer Pilot Study - Proteome"],"summary":null,"one_liner":null,"identifiers":[{"scheme":"pdc_study_id","value":"PDC000176","url":"https://pdc.cancer.gov/pdc/study/PDC000176","is_primary":true,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL allPrograms","retrieved_at":"2026-09-18T02:36:15.354973Z","snippet":null,"locator":"2 fraction studies grouped by cohort name","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"pdc_study_id","value":"PDC000180","url":"https://pdc.cancer.gov/pdc/study/PDC000180","is_primary":false,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL allPrograms","retrieved_at":"2026-09-18T02:36:15.354973Z","snippet":null,"locator":"2 fraction studies grouped by cohort name","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]}],"repository":{"name":"NCI Proteomic Data Commons","short_name":"PDC","url":"https://pdc.cancer.gov","is_nci_crdc_node":true,"is_nih_repository":true},"additional_repositories":[],"program_name":"Pediatric Brain Tumor Atlas - CBTN","program_url":"https://pdc.cancer.gov/pdc/browse","nci_program":"Pediatric Brain Tumor Atlas - CBTN","generating_institutions":[],"data_generation_funding_role":"generation","version":null,"release_date":"2023-01-01","last_upstream_update":null,"retrieved_at":"2026-09-18T02:36:15.354973Z","landing_page_url":"https://pdc.cancer.gov/pdc/study/PDC000176","cancer_types":[{"label":"Pediatric/AYA Brain Tumors","ontology":null,"code":null,"url":null}],"primary_sites":["Brain"],"subject":{"scope":"single","tissues":["BRAIN"],"evidence":[{"method":"derived","source_url":null,"source_label":"cds.subjects","retrieved_at":null,"snippet":null,"locator":"cancer_types: Pediatric/AYA Brain Tumors; primary_sites: Brain","confidence":"high","reviewer":null,"reviewed_at":null,"note":"A two-thirds histology majority determined the subject."}]},"is_pediatric":null,"model_systems":[],"cohort":{"n_cases":207,"n_samples":null,"n_aliquots":454,"n_files":null,"total_bytes":null,"n_tumor_cases":null,"n_normal_cases":null,"has_matched_normal":null,"demographics":{"sex":{"male":116,"female":83,"not reported":8},"race":{"white":146,"black or african american":18,"not reported":35,"asian":4,"american indian or alaska native":3,"native hawaiian or other pacific islander":1},"ethnicity":{"not hispanic or latino":184,"hispanic or latino":13,"not reported":10},"age_at_diagnosis_years":{"n":199.0,"min":0.2,"median":9.2,"max":30.6},"vital_status":{"Alive":160,"Dead":39,"Not Reported":8},"country_or_region":{},"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy demographic fields","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL allPrograms","retrieved_at":"2026-09-18T02:36:15.354973Z","snippet":null,"locator":"2 fraction studies grouped by cohort name","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"assays":[{"modality":"phosphoproteome","label":"Phosphoproteome mass spectrometry (TMT11 / DDA)","platform":"TMT11","n_cases":207,"n_samples":227,"n_files":null,"data_levels":["raw","peptide/protein matrix"],"access_tier":"open","evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL allPrograms","retrieved_at":"2026-09-18T02:36:15.354973Z","snippet":null,"locator":"2 fraction studies grouped by cohort name","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"proteome","label":"Proteome mass spectrometry (TMT11 / DDA)","platform":"TMT11","n_cases":207,"n_samples":227,"n_files":null,"data_levels":["raw","peptide/protein matrix"],"access_tier":"open","evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL allPrograms","retrieved_at":"2026-09-18T02:36:15.354973Z","snippet":null,"locator":"2 fraction studies grouped by cohort name","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]}],"clinical_variables":[{"name":"pdc:vital_status","harmonized_name":"demographic.vital_status","label":"Vital status","category":"outcome","n_nonmissing":207,"n_not_reported":8,"n_informative":199,"n_total":207,"coverage_pct":96.1,"populated_pct":100.0,"is_repeated":false,"example_values":["Alive","Dead","Not Reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field vital_status over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:cause_of_death","harmonized_name":"demographic.cause_of_death","label":"Cause of death","category":"outcome","n_nonmissing":207,"n_not_reported":207,"n_informative":0,"n_total":207,"coverage_pct":0.0,"populated_pct":100.0,"is_repeated":false,"example_values":["Not Reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field cause_of_death over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:race","harmonized_name":"demographic.race","label":"Race","category":"demographic","n_nonmissing":207,"n_not_reported":35,"n_informative":172,"n_total":207,"coverage_pct":83.1,"populated_pct":100.0,"is_repeated":false,"example_values":["white","not reported","black or african american","asian","american indian or alaska native","native hawaiian or other pacific islander"],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field race over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:ethnicity","harmonized_name":"demographic.ethnicity","label":"Ethnicity","category":"demographic","n_nonmissing":207,"n_not_reported":10,"n_informative":197,"n_total":207,"coverage_pct":95.2,"populated_pct":100.0,"is_repeated":false,"example_values":["not hispanic or latino","hispanic or latino","not reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field ethnicity over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:gender","harmonized_name":"demographic.sex_at_birth","label":"Sex at birth (gender)","category":"demographic","n_nonmissing":207,"n_not_reported":8,"n_informative":199,"n_total":207,"coverage_pct":96.1,"populated_pct":100.0,"is_repeated":false,"example_values":["male","female","not reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field gender over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:morphology","harmonized_name":"diagnoses.morphology","label":"Morphology (ICD-O)","category":"pathology","n_nonmissing":207,"n_not_reported":8,"n_informative":199,"n_total":207,"coverage_pct":96.1,"populated_pct":100.0,"is_repeated":false,"example_values":["9400/3","9391/3","9380/3","9470/3","9505/1","9350/1"],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field morphology over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:primary_diagnosis","harmonized_name":"diagnoses.primary_diagnosis","label":"Primary diagnosis","category":"diagnosis","n_nonmissing":207,"n_not_reported":8,"n_informative":199,"n_total":207,"coverage_pct":96.1,"populated_pct":100.0,"is_repeated":false,"example_values":["Glioma, NOS","Ependymoma, NOS","Glioma, malignant","Medulloblastoma, NOS","Ganglioglioma, NOS","Craniopharyngioma"],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field primary_diagnosis over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:tissue_or_organ_of_origin","harmonized_name":"diagnoses.tissue_or_organ_of_origin","label":"Tissue or organ of origin","category":"diagnosis","n_nonmissing":207,"n_not_reported":8,"n_informative":199,"n_total":207,"coverage_pct":96.1,"populated_pct":100.0,"is_repeated":false,"example_values":["Cerebellum/Posterior Fossa","Temporal lobe","Suprasellar/Hypothalamic/Pituitary","Frontal lobe","Ventricles","Not Reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field tissue_or_organ_of_origin over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:tumor_grade","harmonized_name":"diagnoses.tumor_grade","label":"Tumor grade","category":"pathology","n_nonmissing":207,"n_not_reported":8,"n_informative":199,"n_total":207,"coverage_pct":96.1,"populated_pct":100.0,"is_repeated":false,"example_values":["G1","G2","G4","High Grade","Low Grade","Not Reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field tumor_grade over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:ajcc_pathologic_stage","harmonized_name":"diagnoses.ajcc_pathologic_stage","label":"AJCC pathologic stage","category":"staging","n_nonmissing":207,"n_not_reported":207,"n_informative":0,"n_total":207,"coverage_pct":0.0,"populated_pct":100.0,"is_repeated":false,"example_values":["Not Reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field ajcc_pathologic_stage over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:ajcc_clinical_stage","harmonized_name":"diagnoses.ajcc_clinical_stage","label":"AJCC clinical stage","category":"staging","n_nonmissing":207,"n_not_reported":207,"n_informative":0,"n_total":207,"coverage_pct":0.0,"populated_pct":100.0,"is_repeated":false,"example_values":["Not Reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field ajcc_clinical_stage over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:tumor_stage","harmonized_name":"diagnoses.ajcc_pathologic_stage","label":"AJCC pathologic stage (tumor_stage)","category":"staging","n_nonmissing":207,"n_not_reported":207,"n_informative":0,"n_total":207,"coverage_pct":0.0,"populated_pct":100.0,"is_repeated":false,"example_values":["Unknown","Not Reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field tumor_stage over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:progression_or_recurrence","harmonized_name":"diagnoses.progression_or_recurrence","label":"Progression or recurrence","category":"outcome","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":207,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field progression_or_recurrence over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:last_known_disease_status","harmonized_name":"diagnoses.last_known_disease_status","label":"Last known disease status","category":"outcome","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":207,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field last_known_disease_status over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:prior_treatment","harmonized_name":"diagnoses.prior_treatment","label":"Prior treatment","category":"treatment","n_nonmissing":207,"n_not_reported":207,"n_informative":0,"n_total":207,"coverage_pct":0.0,"populated_pct":100.0,"is_repeated":false,"example_values":["Not Reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field prior_treatment over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:prior_malignancy","harmonized_name":"diagnoses.prior_malignancy","label":"Prior malignancy","category":"diagnosis","n_nonmissing":207,"n_not_reported":207,"n_informative":0,"n_total":207,"coverage_pct":0.0,"populated_pct":100.0,"is_repeated":false,"example_values":["not reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field prior_malignancy over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:synchronous_malignancy","harmonized_name":"diagnoses.synchronous_malignancy","label":"Synchronous malignancy","category":"diagnosis","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":207,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field synchronous_malignancy over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:classification_of_tumor","harmonized_name":"diagnoses.classification_of_tumor","label":"Classification of tumor","category":"pathology","n_nonmissing":207,"n_not_reported":8,"n_informative":199,"n_total":207,"coverage_pct":96.1,"populated_pct":100.0,"is_repeated":false,"example_values":["Initial CNS Tumor","Progressive","Recurrence","Not Reported","Second Malignancy"],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field classification_of_tumor over 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:age_at_diagnosis","harmonized_name":"diagnoses.age_at_diagnosis","label":"Age at diagnosis","category":"demographic","n_nonmissing":199,"n_not_reported":null,"n_informative":null,"n_total":207,"coverage_pct":null,"populated_pct":96.1,"is_repeated":false,"example_values":[],"unit":"days","evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field age_at_diagnosis; a value for 199 of 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:days_to_death","harmonized_name":"demographic.days_to_death","label":"Days to death","category":"outcome","n_nonmissing":0,"n_not_reported":null,"n_informative":null,"n_total":207,"coverage_pct":null,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":"days","evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field days_to_death; a value for 0 of 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:days_to_last_follow_up","harmonized_name":"diagnoses.days_to_last_follow_up","label":"Days to last follow-up","category":"followup","n_nonmissing":172,"n_not_reported":null,"n_informative":null,"n_total":207,"coverage_pct":null,"populated_pct":83.1,"is_repeated":false,"example_values":[],"unit":"days","evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field days_to_last_follow_up; a value for 172 of 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:days_to_recurrence","harmonized_name":"diagnoses.days_to_recurrence","label":"Days to recurrence","category":"outcome","n_nonmissing":8,"n_not_reported":null,"n_informative":null,"n_total":207,"coverage_pct":null,"populated_pct":3.9,"is_repeated":false,"example_values":[],"unit":"days","evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: clinicalPerStudy, field days_to_recurrence; a value for 8 of 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:treatments.treatment_type","harmonized_name":"diagnoses.treatments.treatment_type","label":"Treatment type","category":"treatment","n_nonmissing":0,"n_not_reported":null,"n_informative":null,"n_total":207,"coverage_pct":null,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T03:19:40.197287Z","snippet":null,"locator":"PDC000176: paginatedCaseTreatmentsPerStudy, field treatment_type; informative for 0 of 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:treatments.therapeutic_agents","harmonized_name":"diagnoses.treatments.therapeutic_agents","label":"Therapeutic agents","category":"treatment","n_nonmissing":0,"n_not_reported":null,"n_informative":null,"n_total":207,"coverage_pct":null,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T03:19:40.197287Z","snippet":null,"locator":"PDC000176: paginatedCaseTreatmentsPerStudy, field therapeutic_agents; informative for 0 of 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:treatments.treatment_outcome","harmonized_name":"diagnoses.treatments.treatment_outcome","label":"Treatment outcome","category":"treatment","n_nonmissing":0,"n_not_reported":null,"n_informative":null,"n_total":207,"coverage_pct":null,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T03:19:40.197287Z","snippet":null,"locator":"PDC000176: paginatedCaseTreatmentsPerStudy, field treatment_outcome; informative for 0 of 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:treatments.regimen_or_line_of_therapy","harmonized_name":"diagnoses.treatments.regimen_or_line_of_therapy","label":"Regimen or line of therapy","category":"treatment","n_nonmissing":0,"n_not_reported":null,"n_informative":null,"n_total":207,"coverage_pct":null,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T03:19:40.197287Z","snippet":null,"locator":"PDC000176: paginatedCaseTreatmentsPerStudy, field regimen_or_line_of_therapy; informative for 0 of 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"pdc:treatments.treatment_or_therapy","harmonized_name":"diagnoses.treatments.treatment_or_therapy","label":"Treatment given","category":"treatment","n_nonmissing":0,"n_not_reported":null,"n_informative":null,"n_total":207,"coverage_pct":null,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T03:19:40.197287Z","snippet":null,"locator":"PDC000176: paginatedCaseTreatmentsPerStudy, field treatment_or_therapy; informative for 0 of 207 cases","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]}],"longitudinal":{"has_followup":true,"has_survival_endpoint":true,"survival_endpoints":["overall survival"],"median_followup_months":141.2,"max_followup_months":389.6,"n_cases_with_followup":172,"has_serial_samples":null,"timepoints":[],"n_cases_with_serial":null,"has_treatment_response":false,"response_criteria":[],"evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL clinicalPerStudy","retrieved_at":"2026-09-19T04:11:16.316135Z","snippet":null,"locator":"PDC000176: computed from 207 cases: 39 deaths, 172 with a follow-up time, progression informative for 0","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"access":{"tier":"open","open_components":["2 analytical fraction studies"],"controlled_components":[],"mechanism":"Direct download from the PDC portal or its API; no account required","dua_url":null,"data_access_committee":null,"typical_turnaround":null,"embargo_until":null,"login_required":false,"citation_requirement":"Cite the PDC study identifier and the study's primary publication; PDC asks that the consortium be acknowledged.","license":"Open access under the PDC data use terms","publication_policy_url":"https://pdc.cancer.gov/pdc/data-use-guidelines","evidence":[{"method":"api","source_url":"https://proteomic.datacommons.cancer.gov/graphql","source_label":"PDC GraphQL allPrograms","retrieved_at":"2026-09-18T02:36:15.354973Z","snippet":null,"locator":"2 fraction studies grouped by cohort name","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"useful_for":[],"limitations":[],"inappropriate_uses":[],"primary_publications":[],"reuse":[{"publication":{"pmid":"39040050","pmcid":"PMC11261005","doi":"10.1016/j.isci.2024.110225","title":"METTL1-modulated LSM14A facilitates proliferation and migration in glioblastoma via the stabilization of DDX5.","journal":"iScience","year":2024,"authors_short":"Wang et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/39040050/","is_open_access":true,"citation_count":10,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":null,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"METHODS","author_keys":["fang x","huang j","wang c","zhang d","zhao s"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=METHODS:\"PDC000176\"","source_label":"Europe PMC section search (METHODS)","retrieved_at":"2026-09-18T03:21:10.796406Z","snippet":null,"locator":"accession \"PDC000176\" indexed in METHODS","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"37656187","pmcid":"PMC10500011","doi":"10.1007/s00401-023-02626-5","title":"Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma.","journal":"Acta neuropathologica","year":2023,"authors_short":"Picard et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/37656187/","is_open_access":true,"citation_count":6,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":null,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"METHODS","author_keys":["bartl j","brozou t","faria c","felsberg j","knobbe-thomsen c","langini m","leprivier g","macas j","meyer f","milde t","pandyra a","picard d","plate k","qin n","reifenberger g","reiss y","remke m","roesch a","roque l","roque r","selt f","sigaud r","stachura p","stefanski a","stühler k"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=METHODS:\"PDC000176\"","source_label":"Europe PMC section search (METHODS)","retrieved_at":"2026-09-18T03:21:10.796406Z","snippet":null,"locator":"accession \"PDC000176\" indexed in METHODS","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"41550727","pmcid":"PMC12809280","doi":"10.1016/j.isci.2025.114500","title":"A data-driven pan-cancer proteogenomic analysis reveals the characteristics of human cancer protein expression.","journal":"iScience","year":2026,"authors_short":"Li et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/41550727/","is_open_access":true,"citation_count":4,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":null,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"METHODS","author_keys":["liu x","sha c","wang z"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=METHODS:\"PDC000176\"","source_label":"Europe PMC section search (METHODS)","retrieved_at":"2026-09-18T03:21:10.796406Z","snippet":null,"locator":"accession \"PDC000176\" indexed in METHODS","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"41271695","pmcid":"PMC12638842","doi":"10.1038/s41467-025-65190-4","title":"Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric central nervous system tumors.","journal":"Nature communications","year":2025,"authors_short":"Corbett et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/41271695/","is_open_access":true,"citation_count":2,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":null,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"DATA_AVAILABILITY, METHODS","author_keys":["blauel e","bornhorst m","brown m","chroni a","cole k","corbett r","cresswell-clay e","daggett j","desai h","diskin s","geng z","gonzalez e","hausler r","heath a","kaufman r","macfarland s","mason j","maxwell k","mcquaid s","naqvi a","phul s","resnick a","rokita j","sickler a","storm p","sullivan p","vaksman z","waanders a","waszak s","zhang b","zhong c","zhu y"],"nci_funded_reuse":true,"linked_grants":["R03CA287169","R03CA230366"],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DATA_AVAILABILITY:\"PDC000176\"","source_label":"Europe PMC section search (DATA_AVAILABILITY)","retrieved_at":"2026-09-18T03:21:10.796406Z","snippet":null,"locator":"accession \"PDC000176\" indexed in DATA_AVAILABILITY","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"40276932","pmcid":"PMC12045569","doi":"10.1080/15476286.2025.2498203","title":"The implication of non-AUG-initiated N-terminally extended proteoforms in cancer.","journal":"RNA biology","year":2025,"authors_short":"Pancsa et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/40276932/","is_open_access":true,"citation_count":1,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":null,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"METHODS","author_keys":["andreev d","dean k","pancsa r"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=METHODS:\"PDC000176\"","source_label":"Europe PMC section search (METHODS)","retrieved_at":"2026-09-18T03:21:10.796406Z","snippet":null,"locator":"accession \"PDC000176\" indexed in METHODS","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"41287960","pmcid":"PMC12772127","doi":"10.1021/acs.jproteome.5c00616","title":"Surface Proteomic Analysis Reveals the Presence of Noncanonical Cell Membrane Endoplasmic Reticulum Chaperones in High-Grade Gliomas.","journal":"Journal of proteome research","year":2026,"authors_short":"Minchaca et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/41287960/","is_open_access":true,"citation_count":0,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":null,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"METHODS","author_keys":["bae d","bertoldo j","graber p","jayatilleke n","kavallaris m","ludlow l","mayoh c","merlot a","minchaca a","stringer b"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=METHODS:\"PDC000176\"","source_label":"Europe PMC section search (METHODS)","retrieved_at":"2026-09-18T03:21:10.796406Z","snippet":null,"locator":"accession \"PDC000176\" indexed in METHODS","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"40891528","pmcid":"PMC12402770","doi":"10.1093/gigascience/giaf093","title":"The Open Pediatric Cancer Project.","journal":"GigaScience","year":2025,"authors_short":"Geng et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/40891528/","is_open_access":true,"citation_count":10,"evidence":[]},"tier":"t2_declared","kind":"secondary_analysis","independent_of_generators":null,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"DATA_AVAILABILITY","author_keys":["abdullaev z","aldape k","blackden c","brown m","chinwalla a","chroni a","clark k","coleman n","corbett r","diskin s","dybas j","ennis b","farrel a","farrow b","gaonkar k","geng z","hill d","huang x","jin r","keith k","koptyra m","koschmann c","kraya a","lahiri a","lueder m","maris j","mason j","miller d","naqvi a","phul s","rathi k","resnick a","rokita j","rood b","santi m","shukla s","sickler a","stefankiewicz s","tasian s","taylor d","trooskin g","van k","wafula e","wang p","zhang b","zhang y","zhong c","zhu y"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DATA_AVAILABILITY:\"PDC000176\"","source_label":"Europe PMC section search (DATA_AVAILABILITY)","retrieved_at":"2026-09-18T03:21:10.796406Z","snippet":null,"locator":"accession \"PDC000176\" indexed in DATA_AVAILABILITY","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"40753179","pmcid":"PMC12318123","doi":"10.1038/s41467-025-62237-4","title":"High performance data integration for large-scale analyses of incomplete Omic profiles using Batch-Effect Reduction Trees (BERT).","journal":"Nature communications","year":2025,"authors_short":"Schumann et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/40753179/","is_open_access":true,"citation_count":4,"evidence":[]},"tier":"t2_declared","kind":"secondary_analysis","independent_of_generators":null,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"DATA_AVAILABILITY","author_keys":["neumann j","neumann p","schlumbohm s","schumann y"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DATA_AVAILABILITY:\"PDC000176\"","source_label":"Europe PMC section search (DATA_AVAILABILITY)","retrieved_at":"2026-09-18T03:21:10.796406Z","snippet":null,"locator":"accession \"PDC000176\" indexed in DATA_AVAILABILITY","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"39402594","pmcid":"PMC11472442","doi":"10.1186/s13059-024-03382-9","title":"zMAP toolset: model-based analysis of large-scale proteomic data via a variance stabilizing z-transformation.","journal":"Genome biology","year":2024,"authors_short":"Gui et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/39402594/","is_open_access":true,"citation_count":0,"evidence":[]},"tier":"t2_declared","kind":"secondary_analysis","independent_of_generators":null,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"DATA_AVAILABILITY","author_keys":["cao r","gui x","guo x","huang j","liu x","ruan l","shao z","tan f","zhan l","zhang g","zhou h","zhou s","zhu h"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DATA_AVAILABILITY:\"PDC000176\"","source_label":"Europe PMC section search (DATA_AVAILABILITY)","retrieved_at":"2026-09-18T03:21:10.796406Z","snippet":null,"locator":"accession \"PDC000176\" indexed in DATA_AVAILABILITY","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]}],"reuse_metrics":{"n_candidates_screened":6,"n_by_tier":{"t3_analyzed":6,"t2_declared":4,"t1_accession":0,"t0_mention":1},"n_by_tier_raw":{"t3_analyzed":6,"t2_declared":4,"t1_accession":0,"t0_mention":1},"accession_precision":{"token":"PDC000180","query":"METHODS:\"PDC000180\"","strategy_id":"epmc-literal-precision-v1","needs_correction":false,"precision":1.0,"precision_low":1.0,"precision_high":1.0,"n_sampled":0,"n_checked":0,"n_literal":0,"note":"This accession is a single indexed term, so Europe PMC matches it exactly and the hit count needs no correction."},"n_citations_to_primary_publication":null,"citation_to_reuse_ratio":null,"has_citable_accession":true,"n_verified_reuse":6,"n_reuse_examined":9,"n_independent_reuse":0,"n_nci_funded_reuse":1,"first_reuse_year":2023,"latest_reuse_year":2026,"years_since_release":3.72,"expected_reuse":8.19,"reuse_gap_index":-0.393,"reuse_gap_percentile":38.6,"search_strategy_id":"epmc-index-v3","searched_at":"2026-09-20T18:07:48.304369Z","no_reuse_identified":false,"evidence":[{"method":"derived","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search","source_label":"Europe PMC section-scoped hit counts","retrieved_at":"2026-09-20T18:07:48.304369Z","snippet":null,"locator":"tokens: PDC000176, PDC000180; queries: METHODS:\"PDC000180\"; DATA_AVAILABILITY:\"PDC000180\"; ACCESSION_ID:\"PDC000176\"; REF:\"PDC000180\"","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Index strategy epmc-index-v3. Every dataset is measured with the same single section field per tier, so the counts are comparable; the per-tier value is the largest across the dataset's own accessions, excluding any accession shared with other datasets in the corpus. This accession is a single indexed term, so Europe PMC matches it exactly and the hit count needs no correction."},{"method":"derived","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search","source_label":"Europe PMC first-reference dating","retrieved_at":"2026-09-20T18:12:46.183909Z","snippet":null,"locator":"first referenced in 2023 (METHODS section)","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Availability dated from the literature (epmc-first-reference-v2) rather than from repository file timestamps, which record re-harmonization. This is a lower bound on availability."}]},"underexplored":{"is_underexplored":false,"basis":["Reuse is within the expected range for comparable datasets (index -0.39)."],"index_value":-0.393,"percentile":38.6,"comparator_set":"132 datasets in this corpus with a citable accession and sufficient metadata","evidence":[{"method":"derived","source_url":null,"source_label":"Reuse Gap Index (rgi-huber-v2)","retrieved_at":"2026-09-21T02:11:22.976067Z","snippet":null,"locator":"Huber robust regression of log2(analyzing articles + 1) on cohort size, years available, modality breadth and access tier","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Model, covariates and coefficients are published with the dataset export so the label can be recomputed or contested."}]},"grants":[{"core_project_num":"R03CA287169","project_num":null,"title":"Identification and characterization of genetic risk factors in pediatric brain tumors","pi_names":["Sharon Diskin","Jo Lynne Rokita"],"agency_ic":"NCI","activity_code":"R03","fiscal_years":[2024,2025],"award_amount_usd":356000,"org_name":"CHILDREN'S HOSP OF PHILADELPHIA","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=R03CA287169","role":"reuse","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:49:08.609749Z","snippet":null,"locator":"PMID 41271695 reported under R03CA287169","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"R03CA230366","project_num":null,"title":"Discovering the genetic basis of neuroblastoma initiation and progression","pi_names":["Sharon Diskin"],"agency_ic":"NCI","activity_code":"R03","fiscal_years":[2018,2019],"award_amount_usd":344000,"org_name":"CHILDREN'S HOSP OF PHILADELPHIA","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=R03CA230366","role":"reuse","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:49:08.609749Z","snippet":null,"locator":"PMID 41271695 reported under R03CA230366","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]}],"access_steps":[{"order":1,"action":"Open the study in the PDC portal","detail":"Proteomic data are released open; the portal's use guidelines still apply. This record spans 2 PDC studies; repeat for each.","url":"https://pdc.cancer.gov/pdc/study/PDC000176","requires":[],"est_time":"5 minutes","cli_snippet":null,"audience":"human","evidence":[{"method":"derived","source_url":"https://pdc.cancer.gov/pdc/study/PDC000176","source_label":"PDC access documentation","retrieved_at":"2026-09-21T12:30:59.431760Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]},{"order":2,"action":"Accept the data use guidelines and download","detail":"The portal asks for acknowledgement and citation, not a data access request.","url":"https://pdc.cancer.gov/pdc/data-use-guidelines","requires":[],"est_time":"minutes to hours, by study size","cli_snippet":null,"audience":"human","evidence":[{"method":"derived","source_url":"https://pdc.cancer.gov/pdc/data-use-guidelines","source_label":"PDC access documentation","retrieved_at":"2026-09-21T12:30:59.431762Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]},{"order":3,"action":"Resolve the study UUID, then fetch the file manifest","detail":"filesPerStudy keys on the study UUID, not on PDC000176: called with the pdc_study_id it returns the right number of rows with every column null. Resolve the UUID first and pass the terms acknowledgement.","url":"https://pdc.cancer.gov/data-dictionary/publicapi-documentation/","requires":[],"est_time":null,"cli_snippet":"python - <<'PY'\nimport requests\nAPI = \"https://proteomic.datacommons.cancer.gov/graphql\"\n\ndef gql(query, **variables):\n    r = requests.post(API, json={\"query\": query, \"variables\": variables}, timeout=180)\n    r.raise_for_status()\n    body = r.json()\n    if body.get(\"errors\"):\n        raise RuntimeError(body[\"errors\"][0][\"message\"])\n    return body[\"data\"]\n\nstudy = gql('query($id:String!){ study(pdc_study_id:$id acceptDUA:true){ study_id } }',\n            id=\"PDC000176\")[\"study\"][0]\nfiles = gql('query($sid:String!){ filesPerStudy(study_id:$sid acceptDUA:true)'\n            '{ file_id file_name file_size } }', sid=study[\"study_id\"])[\"filesPerStudy\"]\nprint(len(files), \"files\")\nPY","audience":"agent","evidence":[{"method":"derived","source_url":"https://pdc.cancer.gov/data-dictionary/publicapi-documentation/","source_label":"PDC access documentation","retrieved_at":"2026-09-21T12:30:59.431764Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]}],"analysis_examples":[],"agent_package":{"json_url":"/data/datasets/pdc-pediatric-brain-cancer-pilot-study.json","jsonld_url":"/data/jsonld/pdc-pediatric-brain-cancer-pilot-study.jsonld","croissant_url":"/data/croissant/pdc-pediatric-brain-cancer-pilot-study.json","instructions_url":"/data/agent/pdc-pediatric-brain-cancer-pilot-study.md","bundle_url":null,"mcp_resource_uri":null},"related_dataset_ids":[],"related_underexplored_ids":[],"review":{"status":"machine_only","reviewer":null,"reviewer_affiliation":null,"reviewed_at":null,"sections_reviewed":[],"open_questions":[],"notes":null},"verification":{"last_verified_at":null,"link_checks":[],"n_links_ok":0,"n_links_broken":0,"upstream_version_seen":null,"upstream_version_changed":false,"upstream_counts_seen":{},"upstream_drift":{},"notes":[]},"is_showcase":false,"completeness_score":32.1,"tags":["pdc","proteogenomics"],"search_text":null}