{"id":"idc-rms-mutation-prediction","title":"RMS-Mutation-Prediction","short_title":"rms_mutation_prediction","aliases":["rms_mutation_prediction"],"summary":"RMS is an aggressive soft tissue tumor which is associated with a broad range of pathological mutations. Multiple studies have identified recurrent mutations and chromosomal translocations which are associated with poor outcome in RMS patients. Since not all patients are screened for these mutations with molecular testing, there is a need to develop tools which accurately identify these alterations at diagnosis. Our study associated with these images applied deep learning with convolutional neural networks to learn mutation-associated histological features from H&E images from diagnostic RMS specimens. Please see the RMS-Mutation-Prediction information page to learn more about the images and to obtain any supporting metadata for this collection.","one_liner":null,"identifiers":[{"scheme":"idc_collection_id","value":"rms_mutation_prediction","url":"https://portal.imaging.datacommons.cancer.gov/explore/?collection_id=rms_mutation_prediction","is_primary":true,"evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/rms_mutation_prediction","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"tcia_collection","value":"RMS-Mutation-Prediction","url":"https://www.cancerimagingarchive.net/collections/","is_primary":false,"evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/rms_mutation_prediction","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"zenodo","value":"10.5281/zenodo.8225131","url":null,"is_primary":false,"evidence":[{"method":"fulltext","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/rms_mutation_prediction","source_label":"IDC collection description","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":"logical features from H&E images from diagnostic RMS specimens. Please see the RMS-Mutation-Prediction information page to learn more about the images and to obtain any supporting metadata for this c","locator":"accession extracted from description prose","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Cross-repository link recovered from prose; verify before relying on it."}]}],"repository":{"name":"NCI Imaging Data Commons","short_name":"IDC","url":"https://portal.imaging.datacommons.cancer.gov","is_nci_crdc_node":true,"is_nih_repository":true},"additional_repositories":[],"program_name":"NCI Imaging Data Commons / The Cancer Imaging Archive","program_url":"https://imaging.datacommons.cancer.gov/","nci_program":"IDC","generating_institutions":[],"data_generation_funding_role":"unknown","version":null,"release_date":null,"last_upstream_update":null,"retrieved_at":"2026-09-18T02:44:36.389375Z","landing_page_url":"https://portal.imaging.datacommons.cancer.gov/explore/?collection_id=rms_mutation_prediction","cancer_types":[{"label":"Rhabdomyosarcoma","ontology":null,"code":null,"url":null}],"primary_sites":["Various"],"subject":{"scope":"single","tissues":["SOFT_TISSUE"],"evidence":[{"method":"derived","source_url":null,"source_label":"cds.subjects","retrieved_at":null,"snippet":null,"locator":"cancer_types: Rhabdomyosarcoma; primary_sites: Various","confidence":"high","reviewer":null,"reviewed_at":null,"note":"A two-thirds histology majority determined the subject."}]},"is_pediatric":null,"model_systems":[],"cohort":{"n_cases":403,"n_samples":null,"n_aliquots":null,"n_files":null,"total_bytes":null,"n_tumor_cases":null,"n_normal_cases":null,"has_matched_normal":null,"demographics":{"sex":{},"race":{},"ethnicity":{},"age_at_diagnosis_years":{},"vital_status":{},"country_or_region":{},"evidence":[]},"evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/rms_mutation_prediction","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"assays":[{"modality":"radiology","label":"DICOM medical imaging","platform":null,"n_cases":403,"n_samples":null,"n_files":null,"data_levels":["DICOM series"],"access_tier":"open","evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/rms_mutation_prediction","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"clinical","label":"Clinical (accompanying data, per IDC supporting_data)","platform":null,"n_cases":null,"n_samples":null,"n_files":null,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/rms_mutation_prediction","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":"field: supporting_data","confidence":"medium","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"wgs","label":"Genomics (accompanying data, per IDC supporting_data)","platform":null,"n_cases":null,"n_samples":null,"n_files":null,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/rms_mutation_prediction","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":"field: supporting_data","confidence":"medium","reviewer":null,"reviewed_at":null,"note":null}]}],"clinical_variables":[],"longitudinal":{"has_followup":null,"has_survival_endpoint":null,"survival_endpoints":[],"median_followup_months":null,"max_followup_months":null,"n_cases_with_followup":null,"has_serial_samples":null,"timepoints":[],"n_cases_with_serial":null,"has_treatment_response":null,"response_criteria":[],"evidence":[]},"access":{"tier":"open","open_components":[],"controlled_components":[],"mechanism":"Public DICOM download from the IDC portal, its API, or the idc-index Python package; no account required for public collections.","dua_url":null,"data_access_committee":null,"typical_turnaround":null,"embargo_until":null,"login_required":false,"citation_requirement":"Cite the collection DOI and the IDC/TCIA data-citation guidance.","license":"Per-collection license, typically CC BY 3.0/4.0 or CC BY-NC","publication_policy_url":"https://www.cancerimagingarchive.net/data-usage-policies-and-restrictions/","evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/rms_mutation_prediction","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"useful_for":[],"limitations":[{"kind":"harmonization","statement":"Clinical data arrive as 3 collection-specific table(s) with 39 columns in total, named by the submitting trial rather than by a shared vocabulary. The variables exist, but they cannot be compared field by field with the harmonized repositories, so this record's analysis verdicts stay unmeasured.","severity":"major","affected_analyses":[],"mitigation":"Read the table's own schema from https://api.imaging.datacommons.cancer.gov/v3/clinical/tables before planning an analysis.","evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/clinical/tables","source_label":"IDC v3 API /clinical/tables","retrieved_at":"2026-09-19T03:20:46.830869Z","snippet":null,"locator":"collection_id=rms_mutation_prediction: 3 table(s), 39 columns in total","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]}],"inappropriate_uses":[],"primary_publications":[],"reuse":[],"reuse_metrics":{"n_candidates_screened":0,"n_by_tier":{},"n_by_tier_raw":{},"accession_precision":null,"n_citations_to_primary_publication":null,"citation_to_reuse_ratio":null,"has_citable_accession":false,"n_verified_reuse":null,"n_reuse_examined":0,"n_independent_reuse":0,"n_nci_funded_reuse":0,"first_reuse_year":null,"latest_reuse_year":null,"years_since_release":null,"expected_reuse":null,"reuse_gap_index":null,"reuse_gap_percentile":null,"search_strategy_id":"epmc-index-v3","searched_at":"2026-09-20T18:07:31.360251Z","no_reuse_identified":false,"evidence":[{"method":"derived","source_url":null,"source_label":"reuse index","retrieved_at":"2026-09-20T18:07:31.360251Z","snippet":null,"locator":null,"confidence":"low","reviewer":null,"reviewed_at":null,"note":"This dataset has no accession specific enough to search for in the literature, so citation-based reuse cannot be measured. Absence of a count here is not evidence of absence of reuse."}]},"underexplored":{"is_underexplored":false,"basis":["Not assessed: this dataset has no accession specific enough for citation-based reuse tracing, so a shortfall cannot be measured."],"index_value":null,"percentile":null,"comparator_set":"rgi-huber-v2","evidence":[]},"grants":[],"access_steps":[{"order":1,"action":"Open the collection in the IDC portal","detail":"Browse the series before downloading; imaging collections can be very large.","url":"https://portal.imaging.datacommons.cancer.gov/explore/?collection_id=rms_mutation_prediction","requires":[],"est_time":"5 minutes","cli_snippet":null,"audience":"human","evidence":[{"method":"derived","source_url":"https://portal.imaging.datacommons.cancer.gov/explore/?collection_id=rms_mutation_prediction","source_label":"IDC access documentation","retrieved_at":"2026-09-21T12:30:59.430192Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]},{"order":2,"action":"Read the collection's own licence","detail":"Per-collection license, typically CC BY 3.0/4.0 or CC BY-NC. IDC licences differ by collection.","url":"https://www.cancerimagingarchive.net/data-usage-policies-and-restrictions/","requires":[],"est_time":"5 minutes","cli_snippet":null,"audience":"human","evidence":[{"method":"derived","source_url":"https://www.cancerimagingarchive.net/data-usage-policies-and-restrictions/","source_label":"IDC access documentation","retrieved_at":"2026-09-21T12:30:59.430194Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]},{"order":3,"action":"Download with idc-index","detail":"The package resolves the collection to its buckets and pulls selected data.","url":"https://github.com/ImagingDataCommons/idc-index","requires":[],"est_time":"hours for a full collection","cli_snippet":"pip install idc-index\npython - <<'PY'\nfrom idc_index import IDCClient\nIDCClient().download_from_selection(collection_id=\"rms_mutation_prediction\", downloadDir=\".\")\nPY","audience":"human","evidence":[{"method":"derived","source_url":"https://github.com/ImagingDataCommons/idc-index","source_label":"IDC access documentation","retrieved_at":"2026-09-21T12:30:59.430196Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]},{"order":4,"action":"List the series before pulling pixels","detail":"List modality and size first so an agent can choose what to fetch.","url":"https://learn.canceridc.dev/","requires":[],"est_time":null,"cli_snippet":"python - <<'PY'\nfrom idc_index import IDCClient\ni = IDCClient().index\ns = i[i[\"collection_id\"] == \"rms_mutation_prediction\"]\nprint(len(s), \"series\", s[\"PatientID\"].nunique(), \"patients\",\n      round(s[\"series_size_MB\"].sum() / 1024, 1), \"GB\")\nprint(s[\"Modality\"].value_counts().to_dict())\nPY","audience":"agent","evidence":[{"method":"derived","source_url":"https://learn.canceridc.dev/","source_label":"IDC access documentation","retrieved_at":"2026-09-21T12:30:59.430198Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]}],"analysis_examples":[],"agent_package":{"json_url":"/data/datasets/idc-rms-mutation-prediction.json","jsonld_url":"/data/jsonld/idc-rms-mutation-prediction.jsonld","croissant_url":"/data/croissant/idc-rms-mutation-prediction.json","instructions_url":"/data/agent/idc-rms-mutation-prediction.md","bundle_url":null,"mcp_resource_uri":null},"related_dataset_ids":[],"related_underexplored_ids":[],"review":{"status":"machine_only","reviewer":null,"reviewer_affiliation":null,"reviewed_at":null,"sections_reviewed":[],"open_questions":[],"notes":null},"verification":{"last_verified_at":null,"link_checks":[],"n_links_ok":0,"n_links_broken":0,"upstream_version_seen":null,"upstream_version_changed":false,"upstream_counts_seen":{},"upstream_drift":{},"notes":[]},"is_showcase":false,"completeness_score":16.1,"tags":["idc","imaging","has-clinical-table","imaging-genomics","has-derived-annotations"],"search_text":null}