{"id":"idc-eay131","title":"EAY131","short_title":"eay131","aliases":["eay131"],"summary":"This collection contains imaging and clinical data for \"unmatched\" patients who didn't meet the criteria for the genetic sub-studies in the \"Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial).\" This trial was sponsored by the National Cancer Institute and performed by the ECOG-ACRIN Cancer Research Group under study numbers NCT02465060 and EAY131. The Study Chair was Keith T Flaherty, MD. Please see the EAY131 wiki page to learn more about the images and to obtain any supporting metadata for this collection.","one_liner":null,"identifiers":[{"scheme":"idc_collection_id","value":"eay131","url":"https://portal.imaging.datacommons.cancer.gov/explore/?collection_id=eay131","is_primary":true,"evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/eay131","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"tcia_collection","value":"EAY131","url":"https://www.cancerimagingarchive.net/collections/","is_primary":false,"evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/eay131","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"doi","value":"10.7937/c5ke-yx42","url":null,"is_primary":false,"evidence":[{"method":"fulltext","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/eay131","source_label":"IDC collection description","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":"study numbers NCT02465060 and EAY131. The Study Chair was Keith T Flaherty, MD. Please see the EAY131 wiki page to learn more about the images and to obtain any supporting metadata for this collection.","locator":"accession extracted from description prose","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Cross-repository link recovered from prose; verify before relying on it."}]}],"repository":{"name":"NCI Imaging Data Commons","short_name":"IDC","url":"https://portal.imaging.datacommons.cancer.gov","is_nci_crdc_node":true,"is_nih_repository":true},"additional_repositories":[],"program_name":"NCI Imaging Data Commons / The Cancer Imaging Archive","program_url":"https://imaging.datacommons.cancer.gov/","nci_program":"IDC","generating_institutions":[],"data_generation_funding_role":"unknown","version":null,"release_date":null,"last_upstream_update":null,"retrieved_at":"2026-09-18T02:44:36.389375Z","landing_page_url":"https://portal.imaging.datacommons.cancer.gov/explore/?collection_id=eay131","cancer_types":[{"label":"Adenocarcinoma","ontology":null,"code":null,"url":null},{"label":"Adrenocortical Carcinoma","ontology":null,"code":null,"url":null},{"label":"Anal Cancer","ontology":null,"code":null,"url":null},{"label":"Anal Squamous Cell Carcinoma","ontology":null,"code":null,"url":null},{"label":"Astrocytoma","ontology":null,"code":null,"url":null},{"label":"Bladder Cancer","ontology":null,"code":null,"url":null},{"label":"Brain Cancer","ontology":null,"code":null,"url":null},{"label":"Breast Cancer","ontology":null,"code":null,"url":null},{"label":"Cervical Cancer","ontology":null,"code":null,"url":null},{"label":"Cervical Squamous Cell Carcinoma","ontology":null,"code":null,"url":null},{"label":"Cholangiocarcinoma","ontology":null,"code":null,"url":null},{"label":"Colorectal Cancer","ontology":null,"code":null,"url":null},{"label":"Esophageal Carcinoma","ontology":null,"code":null,"url":null},{"label":"Ewing sarcoma - Peripheral PNET","ontology":null,"code":null,"url":null},{"label":"Gastrointestinal Stromal Tumor","ontology":null,"code":null,"url":null},{"label":"Glioblastoma Multiforme","ontology":null,"code":null,"url":null},{"label":"Glioma","ontology":null,"code":null,"url":null},{"label":"Head and Neck Cancer","ontology":null,"code":null,"url":null},{"label":"Head and Neck Squamous Cell Carcinoma","ontology":null,"code":null,"url":null},{"label":"Hodgkin Lymphoma","ontology":null,"code":null,"url":null},{"label":"Kidney Cancer","ontology":null,"code":null,"url":null},{"label":"Leukemia","ontology":null,"code":null,"url":null},{"label":"Liver Cancer","ontology":null,"code":null,"url":null},{"label":"Lung Adenocarcinoma","ontology":null,"code":null,"url":null},{"label":"Lung Cancer","ontology":null,"code":null,"url":null},{"label":"Lung Squamous Cell Carcinoma","ontology":null,"code":null,"url":null},{"label":"Lymphoma","ontology":null,"code":null,"url":null},{"label":"Melanoma","ontology":null,"code":null,"url":null},{"label":"Mesothelioma","ontology":null,"code":null,"url":null},{"label":"Multiple Myeloma","ontology":null,"code":null,"url":null},{"label":"Nasopharyngeal Cancer","ontology":null,"code":null,"url":null},{"label":"Neuroendocrine cancer (NOS)","ontology":null,"code":null,"url":null},{"label":"Non-small Cell Lung Cancer","ontology":null,"code":null,"url":null},{"label":"Osteosarcoma","ontology":null,"code":null,"url":null},{"label":"Ovarian Cancer","ontology":null,"code":null,"url":null},{"label":"Pancreatic Cancer","ontology":null,"code":null,"url":null},{"label":"Prostate Cancer","ontology":null,"code":null,"url":null},{"label":"Sarcomas","ontology":null,"code":null,"url":null},{"label":"Skin Cancer","ontology":null,"code":null,"url":null},{"label":"Small Cell Lung Cancer","ontology":null,"code":null,"url":null},{"label":"Squamous Cell Carcinoma","ontology":null,"code":null,"url":null},{"label":"Thyroid Cancer","ontology":null,"code":null,"url":null},{"label":"Thymoma","ontology":null,"code":null,"url":null},{"label":"Urothelial - bladder cancer (NOS)","ontology":null,"code":null,"url":null},{"label":"Uveal Melanoma","ontology":null,"code":null,"url":null},{"label":"Wilms Tumor","ontology":null,"code":null,"url":null}],"primary_sites":["Various"],"subject":{"scope":"pan_cancer","tissues":[],"evidence":[{"method":"derived","source_url":null,"source_label":"cds.subjects","retrieved_at":null,"snippet":null,"locator":"cancer_types: Adenocarcinoma, Adrenocortical Carcinoma, Anal Cancer, Anal Squamous Cell Carcinoma, Astrocytoma, Bladder Cancer, Brain Cancer, Breast Cancer, Cervical Cancer, Cervical Squamous Cell Carcinoma, Cholangiocarcinoma, Colorectal Cancer, Esophageal Carcinoma, Ewing sarcoma - Peripheral PNET, Gastrointestinal Stromal Tumor, Glioblastoma Multiforme, Glioma, Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma, Hodgkin Lymphoma, Kidney Cancer, Leukemia, Liver Cancer, Lung Adenocarcinoma, Lung Cancer, Lung Squamous Cell Carcinoma, Lymphoma, Melanoma, Mesothelioma, Multiple Myeloma, Nasopharyngeal Cancer, Neuroendocrine cancer (NOS), Non-small Cell Lung Cancer, Osteosarcoma, Ovarian Cancer, Pancreatic Cancer, Prostate Cancer, Sarcomas, Skin Cancer, Small Cell Lung Cancer, Squamous Cell Carcinoma, Thyroid Cancer, Thymoma, Urothelial - bladder cancer (NOS), Uveal Melanoma, Wilms Tumor; primary_sites: Various","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Four or more repository-stated tissues make this pan-cancer."}]},"is_pediatric":null,"model_systems":[],"cohort":{"n_cases":2813,"n_samples":null,"n_aliquots":null,"n_files":null,"total_bytes":null,"n_tumor_cases":null,"n_normal_cases":null,"has_matched_normal":null,"demographics":{"sex":{},"race":{},"ethnicity":{},"age_at_diagnosis_years":{},"vital_status":{},"country_or_region":{},"evidence":[]},"evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/eay131","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"assays":[{"modality":"radiology","label":"DICOM medical imaging","platform":null,"n_cases":2813,"n_samples":null,"n_files":null,"data_levels":["DICOM series"],"access_tier":"open","evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/eay131","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"clinical","label":"Clinical (accompanying data, per IDC supporting_data)","platform":null,"n_cases":null,"n_samples":null,"n_files":null,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/eay131","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":"field: supporting_data","confidence":"medium","reviewer":null,"reviewed_at":null,"note":null}]}],"clinical_variables":[],"longitudinal":{"has_followup":null,"has_survival_endpoint":null,"survival_endpoints":[],"median_followup_months":null,"max_followup_months":null,"n_cases_with_followup":null,"has_serial_samples":null,"timepoints":[],"n_cases_with_serial":null,"has_treatment_response":null,"response_criteria":[],"evidence":[]},"access":{"tier":"open","open_components":[],"controlled_components":[],"mechanism":"Public DICOM download from the IDC portal, its API, or the idc-index Python package; no account required for public collections.","dua_url":null,"data_access_committee":null,"typical_turnaround":null,"embargo_until":null,"login_required":false,"citation_requirement":"Cite the collection DOI and the IDC/TCIA data-citation guidance.","license":"Per-collection license, typically CC BY 3.0/4.0 or CC BY-NC","publication_policy_url":"https://www.cancerimagingarchive.net/data-usage-policies-and-restrictions/","evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/eay131","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"useful_for":[],"limitations":[{"kind":"missing_data","statement":"IDC serves no clinical table for this collection, so nothing about outcome, stage, treatment or demographics can be read from the repository. Any such variable would have to come from the originating trial or publication. The collection's own supporting_data field nevertheless lists clinical data, so the two disagree.","severity":"blocking","affected_analyses":["survival","treatment response","stage-adjusted modelling","analysis by race or ethnicity"],"mitigation":null,"evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/clinical/tables","source_label":"IDC v3 API /clinical/tables","retrieved_at":"2026-09-19T03:20:46.830869Z","snippet":null,"locator":"collection_id=eay131: no clinical table is served","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]}],"inappropriate_uses":[],"primary_publications":[],"reuse":[],"reuse_metrics":{"n_candidates_screened":0,"n_by_tier":{},"n_by_tier_raw":{},"accession_precision":null,"n_citations_to_primary_publication":null,"citation_to_reuse_ratio":null,"has_citable_accession":false,"n_verified_reuse":null,"n_reuse_examined":0,"n_independent_reuse":0,"n_nci_funded_reuse":0,"first_reuse_year":null,"latest_reuse_year":null,"years_since_release":null,"expected_reuse":null,"reuse_gap_index":null,"reuse_gap_percentile":null,"search_strategy_id":"epmc-index-v3","searched_at":"2026-09-20T18:07:30.691705Z","no_reuse_identified":false,"evidence":[{"method":"derived","source_url":null,"source_label":"reuse index","retrieved_at":"2026-09-20T18:07:30.691705Z","snippet":null,"locator":null,"confidence":"low","reviewer":null,"reviewed_at":null,"note":"This dataset has no accession specific enough to search for in the literature, so citation-based reuse cannot be measured. Absence of a count here is not evidence of absence of reuse."}]},"underexplored":{"is_underexplored":false,"basis":["Not assessed: this dataset has no accession specific enough for citation-based reuse tracing, so a shortfall cannot be measured."],"index_value":null,"percentile":null,"comparator_set":"rgi-huber-v2","evidence":[]},"grants":[],"access_steps":[{"order":1,"action":"Open the collection in the IDC portal","detail":"Browse the series before downloading; imaging collections can be very large.","url":"https://portal.imaging.datacommons.cancer.gov/explore/?collection_id=eay131","requires":[],"est_time":"5 minutes","cli_snippet":null,"audience":"human","evidence":[{"method":"derived","source_url":"https://portal.imaging.datacommons.cancer.gov/explore/?collection_id=eay131","source_label":"IDC access documentation","retrieved_at":"2026-09-21T12:30:59.428273Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]},{"order":2,"action":"Read the collection's own licence","detail":"Per-collection license, typically CC BY 3.0/4.0 or CC BY-NC. IDC licences differ by collection.","url":"https://www.cancerimagingarchive.net/data-usage-policies-and-restrictions/","requires":[],"est_time":"5 minutes","cli_snippet":null,"audience":"human","evidence":[{"method":"derived","source_url":"https://www.cancerimagingarchive.net/data-usage-policies-and-restrictions/","source_label":"IDC access documentation","retrieved_at":"2026-09-21T12:30:59.428276Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]},{"order":3,"action":"Download with idc-index","detail":"The package resolves the collection to its buckets and pulls selected data.","url":"https://github.com/ImagingDataCommons/idc-index","requires":[],"est_time":"hours for a full collection","cli_snippet":"pip install idc-index\npython - <<'PY'\nfrom idc_index import IDCClient\nIDCClient().download_from_selection(collection_id=\"eay131\", downloadDir=\".\")\nPY","audience":"human","evidence":[{"method":"derived","source_url":"https://github.com/ImagingDataCommons/idc-index","source_label":"IDC access documentation","retrieved_at":"2026-09-21T12:30:59.428278Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]},{"order":4,"action":"List the series before pulling pixels","detail":"List modality and size first so an agent can choose what to fetch.","url":"https://learn.canceridc.dev/","requires":[],"est_time":null,"cli_snippet":"python - <<'PY'\nfrom idc_index import IDCClient\ni = IDCClient().index\ns = i[i[\"collection_id\"] == \"eay131\"]\nprint(len(s), \"series\", s[\"PatientID\"].nunique(), \"patients\",\n      round(s[\"series_size_MB\"].sum() / 1024, 1), \"GB\")\nprint(s[\"Modality\"].value_counts().to_dict())\nPY","audience":"agent","evidence":[{"method":"derived","source_url":"https://learn.canceridc.dev/","source_label":"IDC access documentation","retrieved_at":"2026-09-21T12:30:59.428280Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]}],"analysis_examples":[],"agent_package":{"json_url":"/data/datasets/idc-eay131.json","jsonld_url":"/data/jsonld/idc-eay131.jsonld","croissant_url":"/data/croissant/idc-eay131.json","instructions_url":"/data/agent/idc-eay131.md","bundle_url":null,"mcp_resource_uri":null},"related_dataset_ids":[],"related_underexplored_ids":[],"review":{"status":"machine_only","reviewer":null,"reviewer_affiliation":null,"reviewed_at":null,"sections_reviewed":[],"open_questions":[],"notes":null},"verification":{"last_verified_at":null,"link_checks":[],"n_links_ok":0,"n_links_broken":0,"upstream_version_seen":null,"upstream_version_changed":false,"upstream_counts_seen":{},"upstream_drift":{},"notes":[]},"is_showcase":false,"completeness_score":16.1,"tags":["idc","imaging","has-derived-annotations"],"search_text":null}