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Not machine-generated."}]},{"kind":"harmonization","statement":"Nine modalities across four data levels do not cover an identical specimen set, and assay coverage varies by biopsy.","severity":"major","affected_analyses":["Complete-case multimodal integration"],"mitigation":"Build the specimen-level intersection from the Synapse manifests before planning.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908751Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. 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Not machine-generated."}]}],"inappropriate_uses":[{"statement":"Population-level or cohort-level statistical inference.","reason":"The design is deep serial sampling of few patients, not a representative cohort.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908751Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"statement":"Assuming all nine modalities are available for every specimen.","reason":"Coverage varies by biopsy and by level; the intersection is much smaller than the union.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908751Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]}],"primary_publications":[{"pmid":"35243422","pmcid":null,"doi":"10.1016/j.xcrm.2022.100525","title":"An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer","journal":"Cell reports. 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