{"id":"gdc-tcga-gbm","title":"Glioblastoma Multiforme","short_title":"TCGA-GBM","aliases":["tcga_gbm"],"summary":"TCGA glioblastoma is the cohort on which most glioma computational biology was built, and 1,753 articles reference it in methods or results. Its imaging is its least-used asset: radiology exists for 607 of 617 cases and histopathology for 389, held in the Imaging Data Commons rather than the GDC, which is why most analyses treat it as a molecular-only cohort.\nIts follow-up is the fact most likely to trip up a new user. Median recorded follow-up is 12.0 months across 596 of 617 cases, reaching 127 months at the maximum - shorter than many users expect, because it reflects last recorded contact rather than total observation.","one_liner":"617 glioblastomas with twelve measurement types including radiology on 607 and pathology slides on 389 - the reference glioma cohort, with a median follow-up of 12.0 months.","identifiers":[{"scheme":"gdc_project_id","value":"TCGA-GBM","url":"https://portal.gdc.cancer.gov/projects/TCGA-GBM","is_primary":true,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-GBM?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"gdc_program","value":"TCGA","url":null,"is_primary":false,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-GBM?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"dbgap_phs","value":"phs000178","url":"https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000178","is_primary":false,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-GBM?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"idc_collection_id","value":"tcga_gbm","url":"https://portal.imaging.datacommons.cancer.gov/explore/?collection_id=tcga_gbm","is_primary":true,"evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/tcga_gbm","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"tcia_collection","value":"TCGA-GBM","url":"https://www.cancerimagingarchive.net/collections/","is_primary":false,"evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/tcga_gbm","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"doi","value":"10.7937/K9/TCIA.2016.RNYFUYE9","url":null,"is_primary":false,"evidence":[{"method":"fulltext","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/tcga_gbm","source_label":"IDC collection description","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":"s Data Portal to research the link between clinical phenome and tissue genome. Please see the TCGA-GBM page to learn more about the radiology images and to obtain any supporting metadata for t","locator":"accession extracted from description prose","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Cross-repository link recovered from prose; verify before relying on it."}]},{"scheme":"zenodo","value":"10.5281/zenodo.12690010","url":null,"is_primary":false,"evidence":[{"method":"fulltext","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/tcga_gbm","source_label":"IDC collection description","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":"or this collection. Please see the DICOM converted Slide Microscopy images for the TCGA-GBM collection page to learn more about the histopathology images and to obtain any supporting metadata for th","locator":"accession extracted from description prose","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Cross-repository link recovered from prose; verify before relying on it."}]}],"repository":{"name":"NCI Genomic Data Commons","short_name":"GDC","url":"https://portal.gdc.cancer.gov","is_nci_crdc_node":true,"is_nih_repository":true},"additional_repositories":[{"name":"NCI Imaging Data Commons","short_name":"IDC","url":"https://portal.imaging.datacommons.cancer.gov","is_nci_crdc_node":true,"is_nih_repository":true}],"program_name":"TCGA","program_url":"https://portal.gdc.cancer.gov/analysis_page?app=Projects","nci_program":"TCGA","generating_institutions":[],"data_generation_funding_role":"generation","version":null,"release_date":"2009-01-01","last_upstream_update":null,"retrieved_at":"2026-09-18T02:35:58.956190Z","landing_page_url":"https://portal.gdc.cancer.gov/projects/TCGA-GBM","cancer_types":[{"label":"Gliomas","ontology":null,"code":null,"url":null},{"label":"Not Reported","ontology":null,"code":null,"url":null}],"primary_sites":["Brain"],"subject":{"scope":"single","tissues":["BRAIN"],"evidence":[{"method":"derived","source_url":null,"source_label":"cds.subjects","retrieved_at":null,"snippet":null,"locator":"cancer_types: Gliomas, Not Reported; primary_sites: Brain","confidence":"high","reviewer":null,"reviewed_at":null,"note":"A two-thirds histology majority determined the subject."}]},"is_pediatric":null,"model_systems":[],"cohort":{"n_cases":617,"n_samples":null,"n_aliquots":null,"n_files":30587,"total_bytes":263105695079950,"n_tumor_cases":null,"n_normal_cases":null,"has_matched_normal":null,"demographics":{"sex":{"male":366,"female":230,"unknown":4},"race":{"white":507,"black or african american":51,"not reported":29,"asian":13},"ethnicity":{"not hispanic or latino":490,"not reported":97,"hispanic or latino":13},"age_at_diagnosis_years":{"n":596.0,"min":10.9,"q1":50.3,"median":59.8,"q3":69.2,"max":89.3},"vital_status":{"dead":492,"alive":102,"not reported":6},"country_or_region":{"united states":20,"canada":1},"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"demographic.*","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-GBM?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null},{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/tcga_gbm","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"assays":[{"modality":"clinical","label":"Clinical","platform":null,"n_cases":617,"n_samples":null,"n_files":1219,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-GBM?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null},{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/tcga_gbm","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":"field: supporting_data","confidence":"medium","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"radiology","label":"DICOM medical imaging","platform":null,"n_cases":607,"n_samples":null,"n_files":null,"data_levels":["DICOM series"],"access_tier":"open","evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/tcga_gbm","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"copy_number","label":"SNP genotyping array (copy number, germline)","platform":"illumina","n_cases":599,"n_samples":null,"n_files":7348,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-GBM?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"methylation","label":"DNA methylation array","platform":"illumina","n_cases":423,"n_samples":null,"n_files":1350,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-GBM?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"wxs","label":"Whole exome sequencing","platform":"illumina","n_cases":401,"n_samples":null,"n_files":7897,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-GBM?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"histopathology","label":"Whole-slide diagnostic images","platform":"illumina","n_cases":389,"n_samples":null,"n_files":860,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-GBM?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null},{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/tcga_gbm","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":"field: supporting_data","confidence":"medium","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"wgs","label":"Whole genome sequencing","platform":"illumina","n_cases":347,"n_samples":null,"n_files":4688,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-GBM?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null},{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/tcga_gbm","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":"field: supporting_data","confidence":"medium","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"structural_variant","label":"Somatic Structural Variation","platform":null,"n_cases":335,"n_samples":null,"n_files":1089,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-GBM?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"rna_seq","label":"Bulk RNA sequencing","platform":"illumina","n_cases":293,"n_samples":null,"n_files":3519,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-GBM?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"mirna","label":"microRNA sequencing","platform":"illumina","n_cases":273,"n_samples":null,"n_files":834,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-GBM?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"protein_array","label":"Reverse phase protein array","platform":"illumina","n_cases":237,"n_samples":null,"n_files":243,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-GBM?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"atac_seq","label":"ATAC sequencing (chromatin accessibility)","platform":"illumina","n_cases":9,"n_samples":null,"n_files":9,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-GBM?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]}],"clinical_variables":[{"name":"demographic.sex_at_birth","harmonized_name":"demographic.sex_at_birth","label":"Sex at birth","category":"demographic","n_nonmissing":600,"n_not_reported":4,"n_informative":596,"n_total":617,"coverage_pct":96.6,"populated_pct":97.2,"is_repeated":false,"example_values":["male","female","unknown"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: demographic.sex_at_birth","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"demographic.race","harmonized_name":"demographic.race","label":"Race","category":"demographic","n_nonmissing":600,"n_not_reported":29,"n_informative":571,"n_total":617,"coverage_pct":92.5,"populated_pct":97.2,"is_repeated":false,"example_values":["white","black or african american","not reported","asian"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: demographic.race","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"demographic.ethnicity","harmonized_name":"demographic.ethnicity","label":"Ethnicity","category":"demographic","n_nonmissing":600,"n_not_reported":97,"n_informative":503,"n_total":617,"coverage_pct":81.5,"populated_pct":97.2,"is_repeated":false,"example_values":["not hispanic or latino","not reported","hispanic or latino"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: demographic.ethnicity","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"demographic.vital_status","harmonized_name":"demographic.vital_status","label":"Vital status","category":"outcome","n_nonmissing":600,"n_not_reported":6,"n_informative":594,"n_total":617,"coverage_pct":96.3,"populated_pct":97.2,"is_repeated":false,"example_values":["dead","alive","not reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: demographic.vital_status","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"demographic.cause_of_death","harmonized_name":"demographic.cause_of_death","label":"Cause of death","category":"outcome","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":617,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: demographic.cause_of_death","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"demographic.population_group","harmonized_name":"demographic.population_group","label":"Population group","category":"demographic","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":617,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: demographic.population_group","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"demographic.country_of_residence_at_enrollment","harmonized_name":"demographic.country_of_residence_at_enrollment","label":"Country of residence","category":"demographic","n_nonmissing":21,"n_not_reported":0,"n_informative":21,"n_total":617,"coverage_pct":3.4,"populated_pct":3.4,"is_repeated":false,"example_values":["united states","canada"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: demographic.country_of_residence_at_enrollment","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.primary_diagnosis","harmonized_name":"diagnoses.primary_diagnosis","label":"Primary diagnosis","category":"diagnosis","n_nonmissing":600,"n_not_reported":null,"n_informative":null,"n_total":617,"coverage_pct":null,"populated_pct":97.2,"is_repeated":true,"example_values":["glioblastoma","unknown","not reported","adenocarcinoma, nos"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.primary_diagnosis (one-to-many; counts are per record)","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.morphology","harmonized_name":"diagnoses.morphology","label":"Morphology (ICD-O)","category":"pathology","n_nonmissing":600,"n_not_reported":null,"n_informative":null,"n_total":617,"coverage_pct":null,"populated_pct":97.2,"is_repeated":true,"example_values":["9440/3","unknown","not reported","8140/3"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.morphology (one-to-many; counts are per record)","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.tissue_or_organ_of_origin","harmonized_name":"diagnoses.tissue_or_organ_of_origin","label":"Tissue or organ of origin","category":"diagnosis","n_nonmissing":600,"n_not_reported":null,"n_informative":null,"n_total":617,"coverage_pct":null,"populated_pct":97.2,"is_repeated":true,"example_values":["brain, nos","not reported","frontal lobe","temporal lobe","occipital lobe","prostate gland"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.tissue_or_organ_of_origin (one-to-many; counts are per record)","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.ajcc_pathologic_stage","harmonized_name":"diagnoses.ajcc_pathologic_stage","label":"AJCC pathologic stage","category":"staging","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":617,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.ajcc_pathologic_stage","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.ajcc_clinical_stage","harmonized_name":"diagnoses.ajcc_clinical_stage","label":"AJCC clinical stage","category":"staging","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":617,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.ajcc_clinical_stage","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.tumor_grade","harmonized_name":"diagnoses.tumor_grade","label":"Tumor grade","category":"pathology","n_nonmissing":4,"n_not_reported":4,"n_informative":0,"n_total":617,"coverage_pct":0.0,"populated_pct":0.6,"is_repeated":false,"example_values":["not reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.tumor_grade","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.prior_treatment","harmonized_name":"diagnoses.prior_treatment","label":"Prior treatment","category":"treatment","n_nonmissing":600,"n_not_reported":null,"n_informative":null,"n_total":617,"coverage_pct":null,"populated_pct":97.2,"is_repeated":true,"example_values":["no","yes","not reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.prior_treatment (one-to-many; counts are per record)","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.prior_malignancy","harmonized_name":"diagnoses.prior_malignancy","label":"Prior malignancy","category":"diagnosis","n_nonmissing":600,"n_not_reported":552,"n_informative":48,"n_total":617,"coverage_pct":7.8,"populated_pct":97.2,"is_repeated":false,"example_values":["not reported","no","yes"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.prior_malignancy","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.synchronous_malignancy","harmonized_name":"diagnoses.synchronous_malignancy","label":"Synchronous malignancy","category":"diagnosis","n_nonmissing":600,"n_not_reported":567,"n_informative":33,"n_total":617,"coverage_pct":5.3,"populated_pct":97.2,"is_repeated":false,"example_values":["not reported","no"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.synchronous_malignancy","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.progression_or_recurrence","harmonized_name":"diagnoses.progression_or_recurrence","label":"Progression or recurrence","category":"outcome","n_nonmissing":4,"n_not_reported":4,"n_informative":0,"n_total":617,"coverage_pct":0.0,"populated_pct":0.6,"is_repeated":false,"example_values":["not reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.progression_or_recurrence","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.last_known_disease_status","harmonized_name":"diagnoses.last_known_disease_status","label":"Last known disease status","category":"outcome","n_nonmissing":4,"n_not_reported":4,"n_informative":0,"n_total":617,"coverage_pct":0.0,"populated_pct":0.6,"is_repeated":false,"example_values":["not reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.last_known_disease_status","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.classification_of_tumor","harmonized_name":"diagnoses.classification_of_tumor","label":"Classification of tumor","category":"pathology","n_nonmissing":600,"n_not_reported":null,"n_informative":null,"n_total":617,"coverage_pct":null,"populated_pct":97.2,"is_repeated":true,"example_values":["primary","progression","unknown","recurrence","not reported","prior primary"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.classification_of_tumor (one-to-many; counts are per record)","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.treatments.treatment_type","harmonized_name":"diagnoses.treatments.treatment_type","label":"Treatment type","category":"treatment","n_nonmissing":581,"n_not_reported":null,"n_informative":null,"n_total":617,"coverage_pct":null,"populated_pct":94.2,"is_repeated":true,"example_values":["radiation therapy, nos","radiation, external beam","chemotherapy","pharmaceutical therapy, nos","surgery, nos","targeted molecular therapy"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.treatments.treatment_type (one-to-many; counts are per record)","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.treatments.treatment_or_therapy","harmonized_name":"diagnoses.treatments.treatment_or_therapy","label":"Treatment given","category":"treatment","n_nonmissing":581,"n_not_reported":null,"n_informative":null,"n_total":617,"coverage_pct":null,"populated_pct":94.2,"is_repeated":true,"example_values":["yes","no","unknown","not reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.treatments.treatment_or_therapy (one-to-many; counts are per record)","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.treatments.therapeutic_agents","harmonized_name":"diagnoses.treatments.therapeutic_agents","label":"Therapeutic agents","category":"treatment","n_nonmissing":442,"n_not_reported":null,"n_informative":null,"n_total":617,"coverage_pct":null,"populated_pct":71.6,"is_repeated":true,"example_values":["temozolomide","bevacizumab","dexamethasone","lomustine","carmustine","irinotecan hydrochloride"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.treatments.therapeutic_agents (one-to-many; counts are per record)","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.treatments.treatment_outcome","harmonized_name":"diagnoses.treatments.treatment_outcome","label":"Treatment outcome","category":"treatment","n_nonmissing":147,"n_not_reported":78,"n_informative":69,"n_total":617,"coverage_pct":11.2,"populated_pct":23.8,"is_repeated":false,"example_values":["not reported","treatment ongoing","unknown","stable disease","progressive disease","complete response"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.treatments.treatment_outcome","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.treatments.regimen_or_line_of_therapy","harmonized_name":"diagnoses.treatments.regimen_or_line_of_therapy","label":"Regimen or line of therapy","category":"treatment","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":617,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: diagnoses.treatments.regimen_or_line_of_therapy","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"follow_ups.disease_response","harmonized_name":"follow_ups.disease_response","label":"Disease response at follow-up","category":"followup","n_nonmissing":544,"n_not_reported":13,"n_informative":531,"n_total":617,"coverage_pct":86.1,"populated_pct":88.2,"is_repeated":false,"example_values":["wt-with tumor","tf-tumor free","unknown"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: follow_ups.disease_response","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"follow_ups.progression_or_recurrence","harmonized_name":"follow_ups.progression_or_recurrence","label":"Progression at follow-up","category":"followup","n_nonmissing":387,"n_not_reported":0,"n_informative":387,"n_total":617,"coverage_pct":62.7,"populated_pct":62.7,"is_repeated":false,"example_values":["yes"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: follow_ups.progression_or_recurrence","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"follow_ups.ecog_performance_status","harmonized_name":"follow_ups.ecog_performance_status","label":"ECOG performance status","category":"followup","n_nonmissing":80,"n_not_reported":4,"n_informative":76,"n_total":617,"coverage_pct":12.3,"populated_pct":13.0,"is_repeated":false,"example_values":["1","2","0","3","unknown","4"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: follow_ups.ecog_performance_status","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"exposures.tobacco_smoking_status","harmonized_name":"exposures.tobacco_smoking_status","label":"Tobacco smoking status","category":"exposure","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":617,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: exposures.tobacco_smoking_status","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"exposures.alcohol_history","harmonized_name":"exposures.alcohol_history","label":"Alcohol history","category":"exposure","n_nonmissing":4,"n_not_reported":4,"n_informative":0,"n_total":617,"coverage_pct":0.0,"populated_pct":0.6,"is_repeated":false,"example_values":["not reported"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:56.676312Z","snippet":null,"locator":"facet: exposures.alcohol_history","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]}],"longitudinal":{"has_followup":true,"has_survival_endpoint":true,"survival_endpoints":["overall survival","progression-free interval"],"median_followup_months":12.0,"max_followup_months":127.5,"n_cases_with_followup":596,"has_serial_samples":true,"timepoints":[],"n_cases_with_serial":595,"has_treatment_response":true,"response_criteria":["complete response","progressive disease","stable disease","treatment ongoing"],"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22TCGA-GBM%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&fields=diagnoses.age_at_diagnosis%2Cdiagnoses.days_to_last_follow_up%2Cdiagnoses.days_to_recurrence%2Cdemographic.days_to_death%2Cdemographic.vital_status%2Cfollow_ups.days_to_follow_up%2Cfollow_ups.days_to_progression%2Cdiagnoses.treatments.days_to_treatment_start&size=617&format=json","source_label":"GDC API /cases (case-level fields)","retrieved_at":"2026-09-18T02:35:58.477726Z","snippet":null,"locator":"computed from 617 cases; follow-up time derivable for 596 of them","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"access":{"tier":"mixed","open_components":["13,117 open-access files"],"controlled_components":["17,470 controlled-access files"],"mechanism":"Data Access Request through dbGaP using an eRA Commons account; institutional signing official approval required","dua_url":"https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000178","data_access_committee":"NCI Data Access Committee","typical_turnaround":"days to a few weeks after signing official approval","embargo_until":null,"login_required":true,"citation_requirement":"Cite the dataset accession and the program's publication guidelines; see the GDC publication policy.","license":"NIH Genomic Data Sharing Policy terms","publication_policy_url":"https://gdc.cancer.gov/about-data/publications","evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/tcga_gbm","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"useful_for":[{"question":"Do imaging features add prognostic or subtype information beyond molecular data in glioblastoma?","rationale":"Radiology on 607 cases and pathology slides on 389, paired with expression on 293, methylation on 423 and copy number on 599 for the same patients. Glioma is the disease where imaging is most clinically central, and this pairing is openly available.","required_fields":[],"required_modalities":["radiology","histopathology","rna_seq","methylation"],"feasibility":"needs_linkage","approx_n":389,"statistical_note":"The intersection of imaging and expression is well below 617; build it explicitly. Imaging is in a separate repository from the molecular data.","exemplar_pmid":null,"topics":["multimodal","imaging","glioma"],"evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908591Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"question":"Does a new glioma classifier reproduce established methylation subgroups?","rationale":"Methylation on 423 cases with subgroup definitions established across a large literature makes this the standard validation set for glioma classification.","required_fields":[],"required_modalities":["methylation","rna_seq"],"feasibility":"direct","approx_n":423,"statistical_note":"Extensive prior use means good performance here is weak evidence of generalization.","exemplar_pmid":null,"topics":["methods-benchmarking","molecular-subtypes","glioma"],"evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908591Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"question":"Which molecular features associate with survival in glioblastoma?","rationale":"Vital status is informative for 96.3% of 617 cases, giving a clean overall survival endpoint on a well-characterized cohort.","required_fields":[],"required_modalities":["rna_seq","methylation","clinical","outcome"],"feasibility":"direct","approx_n":594,"statistical_note":"Follow-up time is recorded across three different GDC fields and is null in the most obvious one; derive it from days to death, follow-up records and diagnosis records together, and state your derivation.","exemplar_pmid":null,"topics":["survival","glioma"],"evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908591Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]}],"limitations":[{"kind":"missing_data","statement":"Progression or recurrence is populated for 0.6% of cases and informative for none, so progression-free survival cannot be derived at all.","severity":"blocking","affected_analyses":["Progression-free survival","Recurrence biology"],"mitigation":"Restrict to overall survival, derived from vital status and days to death.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908591Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"kind":"treatment_context","statement":"Treatment type is recorded for 94% and therapeutic agents for 72%, but the cohort spans an era in which standard therapy changed, and treatment is unrandomised.","severity":"major","affected_analyses":["Treatment-response claims","Predictive biomarkers"],"mitigation":"Adjust for enrolment era; frame findings as associative.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908591Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"kind":"statistical_power","statement":"Molecular coverage is uneven - expression 293, exome 401, ATAC 9 - so multi-omic analyses run on much less than 617 cases.","severity":"major","affected_analyses":["Multi-omic integration"],"mitigation":"Build the intersection first; note that ATAC covers 9 cases only.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908591Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"kind":"platform_obsolescence","statement":"Methylation and copy number rely on platforms no longer in routine use.","severity":"minor","affected_analyses":["Integration with contemporary cohorts"],"mitigation":"Restrict to shared features.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908591Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"kind":"population_coverage","statement":"507 of 617 patients are recorded as white and 51 as Black or African American.","severity":"major","affected_analyses":["Disparities research"],"mitigation":"Limited power for race-stratified analysis.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908591Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]}],"inappropriate_uses":[{"statement":"Progression-free survival analysis.","reason":"Progression is informative for no case in the record.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908591Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"statement":"Claiming a classifier generalizes from TCGA-GBM performance alone.","reason":"The cohort has been used extensively for method development.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908591Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]}],"primary_publications":[{"pmid":"18772890","pmcid":null,"doi":null,"title":"Comprehensive genomic characterization defines human glioblastoma genes and core pathways","journal":"Nature","year":2008,"authors_short":null,"n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/18772890/","is_open_access":null,"citation_count":null,"evidence":[{"method":"curated","source_url":"https://pubmed.ncbi.nlm.nih.gov/18772890/","source_label":"Marker paper (curated registry)","retrieved_at":"2026-09-21T12:30:56.916748Z","snippet":null,"locator":"marker paper for gdc-tcga-gbm","confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-20","note":"Named by a reviewer as the publication that describes this cohort and reports its data generation, and verified against Europe PMC by title, journal and year. This is what the dataset's citation count counts citations to, and the only thing a generation award is attributed from."}]}],"reuse":[{"publication":{"pmid":"40467633","pmcid":"PMC12137945","doi":"10.1038/s41597-025-05117-2","title":"Updating TCGA glioma classification through integration of molecular data following the latest WHO guidelines.","journal":"Scientific data","year":2025,"authors_short":"de et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/40467633/","is_open_access":true,"citation_count":9,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":true,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"METHODS","author_keys":["coletti r","costa b","gonçalves c","lopes m","martins e","vinga s"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=METHODS:\"TCGA-GBM\"","source_label":"Europe PMC section search (METHODS)","retrieved_at":"2026-09-18T03:16:27.493111Z","snippet":null,"locator":"accession \"TCGA-GBM\" indexed in METHODS","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"41292185","pmcid":"PMC12647366","doi":"10.1002/ctm2.70517","title":"Integrated pathway analysis identifies prognostically relevant subtypes of glioblastoma characterized by abnormalities in multi-omics.","journal":"Clinical and translational medicine","year":2025,"authors_short":"Zhang et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/41292185/","is_open_access":true,"citation_count":3,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":true,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"METHODS","author_keys":["dong l","liu d","ouyang x","xia q","zhang p","zhang y","zhong l"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=METHODS:\"TCGA-GBM\"","source_label":"Europe PMC section search (METHODS)","retrieved_at":"2026-09-18T03:16:27.493111Z","snippet":null,"locator":"accession \"TCGA-GBM\" indexed in METHODS","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"41489302","pmcid":"PMC12766902","doi":"10.1002/cns.70738","title":"Tumor Electric Field Therapy Inhibits TGF-β/C1R Signaling Axis-Driven Epithelial-Mesenchymal Transition in Glioblastoma.","journal":"CNS neuroscience & therapeutics","year":2026,"authors_short":"Chen et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/41489302/","is_open_access":true,"citation_count":1,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":true,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"METHODS","author_keys":["chen j","chen l","chen x","feng y","lan j","liu h","liu j","liu q","liu y","qin l","sun c","zhao x"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=METHODS:\"TCGA-GBM\"","source_label":"Europe PMC section search (METHODS)","retrieved_at":"2026-09-18T03:16:27.493111Z","snippet":null,"locator":"accession \"TCGA-GBM\" indexed in METHODS","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"41049001","pmcid":"PMC12490975","doi":"10.7150/jca.117209","title":"Robust machine-learning based prognostic index using fatty acid metabolism genes predicts prognosis and therapy responses in glioblastoma.","journal":"Journal of Cancer","year":2025,"authors_short":"Zhao et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/41049001/","is_open_access":true,"citation_count":1,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":true,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"METHODS","author_keys":["cao r","qian x","shi z","tang l","wang z","zhang l","zhao e"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=METHODS:\"TCGA-GBM\"","source_label":"Europe PMC section search (METHODS)","retrieved_at":"2026-09-18T03:16:27.493111Z","snippet":null,"locator":"accession \"TCGA-GBM\" indexed in METHODS","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"39941811","pmcid":"PMC11815886","doi":"10.3390/cancers17030445","title":"Robust Cluster Prediction Across Data Types Validates Association of Sex and Therapy Response in GBM.","journal":"Cancers","year":2025,"authors_short":"Gibbs et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/39941811/","is_open_access":true,"citation_count":1,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":true,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"METHODS","author_keys":["aguilar b","barnholtz-sloan j","cioffi g","gibbs d","luo j","mandel j","pan e","pot d","rubin j","umemura y","waite k"],"nci_funded_reuse":true,"linked_grants":["P30CA091842"],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=METHODS:\"TCGA-GBM\"","source_label":"Europe PMC section search (METHODS)","retrieved_at":"2026-09-18T03:16:27.493111Z","snippet":null,"locator":"accession \"TCGA-GBM\" indexed in METHODS","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"40874786","pmcid":"PMC12438089","doi":"10.1158/2767-9764.crc-25-0170","title":"Response to Antiangiogenic Therapy Is Associated with AIMP Protein Family Expression in Glioblastoma and Lower-Grade Gliomas.","journal":"Cancer research communications","year":2025,"authors_short":"Noor et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/40874786/","is_open_access":true,"citation_count":1,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":true,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"METHODS","author_keys":["gevaert o","itakura h","noor h","zheng y"],"nci_funded_reuse":true,"linked_grants":["R01CA260271"],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=METHODS:\"TCGA-GBM\"","source_label":"Europe PMC section search (METHODS)","retrieved_at":"2026-09-18T03:16:27.493111Z","snippet":null,"locator":"accession \"TCGA-GBM\" indexed in METHODS","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"42737734","pmcid":"PMC13566440","doi":"10.3390/ijms27177837","title":"Integrated Network and Transcriptomic Analyses Identify a Candidate Ethanol-ADAM17 Molecular Axis Associated with Glioblastoma Progression.","journal":"International journal of molecular sciences","year":2026,"authors_short":"Arumugam et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/42737734/","is_open_access":true,"citation_count":0,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":true,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"DATA_AVAILABILITY, METHODS","author_keys":["arumugam a","baik h","chang s","huang w","jang n"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DATA_AVAILABILITY:\"TCGA-GBM\"","source_label":"Europe PMC section search (DATA_AVAILABILITY)","retrieved_at":"2026-09-18T03:16:27.493111Z","snippet":null,"locator":"accession \"TCGA-GBM\" indexed in DATA_AVAILABILITY","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":null,"pmcid":null,"doi":"10.64898/2026.08.14.26360452","title":"Methylation-driven Cancer Genes and Methylation Profiling in Glioma: A Comparative Study between East Asian and non-Hispanic White Populations","journal":null,"year":2026,"authors_short":"Newman et al.","n_authors":null,"url":"https://doi.org/10.64898/2026.08.14.26360452","is_open_access":true,"citation_count":0,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":true,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"METHODS","author_keys":["cheng v","dunne n","newman l","sharma-oates a"],"nci_funded_reuse":null,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=METHODS:\"TCGA-GBM\"","source_label":"Europe PMC section search (METHODS)","retrieved_at":"2026-09-18T03:16:27.493111Z","snippet":null,"locator":"accession \"TCGA-GBM\" indexed in METHODS","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"42587836","pmcid":"PMC13466053","doi":"10.3390/cells15151428","title":"Sexual Dimorphism of ZEB1 Expression and Function in Glioblastoma.","journal":"Cells","year":2026,"authors_short":"Whittaker et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/42587836/","is_open_access":true,"citation_count":0,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":true,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"METHODS","author_keys":["davies s","gordon-smith a","kwan j","siebzehnrubl f","whittaker b"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=METHODS:\"TCGA-GBM\"","source_label":"Europe PMC section search (METHODS)","retrieved_at":"2026-09-18T03:16:27.493111Z","snippet":null,"locator":"accession \"TCGA-GBM\" indexed in METHODS","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"42523610","pmcid":"PMC13407271","doi":"10.3389/fonc.2026.1761182","title":"Interpretable machine learning-driven multi-omics risk stratification and drug repurposing nominates Treg/Th17 with gluconeogenesis/lactylation integration as a prognostic and druggable biomarker for glioblastoma patients.","journal":"Frontiers in oncology","year":2026,"authors_short":"Xie et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/42523610/","is_open_access":true,"citation_count":0,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":true,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"METHODS","author_keys":["chen w","weng s","xie s","zhang b"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=METHODS:\"TCGA-GBM\"","source_label":"Europe PMC section search (METHODS)","retrieved_at":"2026-09-18T03:16:27.493111Z","snippet":null,"locator":"accession \"TCGA-GBM\" indexed in METHODS","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]}],"reuse_metrics":{"n_candidates_screened":1399,"n_by_tier":{"t3_analyzed":1399,"t2_declared":174,"t1_accession":0,"t0_mention":272},"n_by_tier_raw":{"t3_analyzed":1399,"t2_declared":174,"t1_accession":0,"t0_mention":272},"accession_precision":{"token":"TCGA-GBM","query":"METHODS:\"TCGA-GBM\"","strategy_id":"epmc-literal-precision-v1","needs_correction":true,"precision":1.0,"precision_low":0.883,"precision_high":1.0,"n_sampled":30,"n_checked":29,"n_literal":29,"note":"29 of 29 sampled open-access articles contain the literal accession TCGA-GBM; the rest match only because Europe PMC indexes the hyphen as a word break. Counts for this dataset are scaled by 100% accordingly."},"n_citations_to_primary_publication":6091,"citation_to_reuse_ratio":4.4,"has_citable_accession":true,"n_verified_reuse":1399,"n_reuse_examined":112,"n_independent_reuse":10,"n_nci_funded_reuse":2,"first_reuse_year":2025,"latest_reuse_year":2026,"years_since_release":17.72,"expected_reuse":538.14,"reuse_gap_index":1.377,"reuse_gap_percentile":80.3,"search_strategy_id":"epmc-index-v3","searched_at":"2026-09-20T18:07:30.968552Z","no_reuse_identified":false,"evidence":[{"method":"derived","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search","source_label":"Europe PMC section-scoped hit counts","retrieved_at":"2026-09-20T18:07:30.968552Z","snippet":null,"locator":"tokens: TCGA-GBM; queries: METHODS:\"TCGA-GBM\"; DATA_AVAILABILITY:\"TCGA-GBM\"; ACCESSION_ID:\"TCGA-GBM\"; REF:\"TCGA-GBM\"","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Index strategy epmc-index-v3. Every dataset is measured with the same single section field per tier, so the counts are comparable; the per-tier value is the largest across the dataset's own accessions, excluding any accession shared with other datasets in the corpus. 29 of 29 sampled open-access articles contain the literal accession TCGA-GBM; the rest match only because Europe PMC indexes the hyphen as a word break. Counts for this dataset are scaled by 100% accordingly."},{"method":"derived","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search","source_label":"Europe PMC first-reference dating","retrieved_at":"2026-09-20T18:09:35.448497Z","snippet":null,"locator":"first referenced in 2009 (METHODS section)","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Availability dated from the literature (epmc-first-reference-v2) rather than from repository file timestamps, which record re-harmonization. This is a lower bound on availability."}]},"underexplored":{"is_underexplored":false,"basis":["Reuse is within the expected range for comparable datasets (index +1.38)."],"index_value":1.377,"percentile":80.3,"comparator_set":"132 datasets in this corpus with a citable accession and sufficient metadata","evidence":[{"method":"derived","source_url":null,"source_label":"Reuse Gap Index (rgi-huber-v2)","retrieved_at":"2026-09-21T02:11:22.976067Z","snippet":null,"locator":"Huber robust regression of log2(analyzing articles + 1) on cohort size, years available, modality breadth and access tier","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Model, covariates and coefficients are published with the dataset export so the label can be recomputed or contested."}]},"grants":[{"core_project_num":"P30CA091842","project_num":null,"title":"Tissue Procurement Core","pi_names":["Mark A. Watson","EDUARDO ROSA-MOLINAR","Adetunji T Toriola","TIMOTHY J. EBERLEIN","Amanda Fishback Cashen","Xiaoxia Cui","Jason Weber","AIMEE S JAMES","Jingqin Luo","Shawn Shafer","MARILYN J SIEGEL","KATHLEEN C SHEEHAN","Young Ah Goo","Grant Anthony Challen","David G DeNardo","Roberta Faccio","Christopher A Maher","Bettina F. Drake","ALBERT M LAI","Joel Richard Garbow","GEOFFREY L UY","FARROKH DEHDASHTI","MEAGAN JACOBY","JEFFREY F. MOLEY","Jeff M. Michalski","ROBERT DAVID SCHREIBER","MATTHEW W. KREUTER","Timothy J. Ley","BARRY A. SIEGEL","Daniel C Link","REID TOWNSEND","RAKESH NAGARAJAN","ROBERT MYERSON","David M Ornitz","HELEN M PIWNICA-WORMS","MICHAEL J. WELCH","MATTHEW J ELLIS","JOSEPH J. H. ACKERMAN","TIMOTHY A GRAUBERT","DONNA B JEFFE","J. Philip MILLER","NANCY L BARTLETT","Paul Joseph Goodfellow","HOWARD L MCLEOD","JOEL PICUS","Edwin B Fisher","BARBARA A ZEHNBAUER","MICHAEL J WELCH","ROBERT REID TOWNSEND","BRIAN SPRINGER"],"agency_ic":"NCI","activity_code":"P30","fiscal_years":[2001,2002,2003,2004,2005,2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018,2019,2020,2021,2022,2023,2024,2025,2026],"award_amount_usd":223241311,"org_name":"WASHINGTON UNIVERSITY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=P30CA091842","role":"infrastructure","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:45:25.114713Z","snippet":null,"locator":"PMID 39941811 reported under P30CA091842","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"R01CA260271","project_num":null,"title":"Multi-scale modeling of glioma for the prediction of treatment response, treatment monitoring and treatment allocation","pi_names":["Olivier Gevaert"],"agency_ic":"NCI","activity_code":"R01","fiscal_years":[2021,2022,2023,2024,2025],"award_amount_usd":3120699,"org_name":"STANFORD UNIVERSITY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=R01CA260271","role":"reuse","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:45:25.114713Z","snippet":null,"locator":"PMID 40874786 reported under R01CA260271","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"U24CA144025","project_num":null,"title":"Harvard Genome Characterization Center","pi_names":["Raju S. Kucherlapati"],"agency_ic":"CA","activity_code":"U24","fiscal_years":[2009,2010,2011,2012,2013,2014,2016],"award_amount_usd":13968228,"org_name":"BRIGHAM AND WOMEN'S HOSPITAL","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U24CA144025","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 18772890 (this dataset's marker paper) reported under U24CA144025","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA143848","project_num":null,"title":"Gene Expression Patterns in Human Tumors Identified Using Transcript Sequencing","pi_names":["David N Hayes","CHARLES M PEROU"],"agency_ic":"CA","activity_code":"U24","fiscal_years":[2009,2010,2011,2012,2013,2014,2016],"award_amount_usd":20842970,"org_name":"UNIV OF NORTH CAROLINA CHAPEL HILL","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U24CA143848","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 18772890 (this dataset's marker paper) reported under U24CA143848","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA126563","project_num":null,"title":"HudsonAlpha Cancer Genome Characterization Center","pi_names":["Richard M Myers"],"agency_ic":"CA","activity_code":"U24","fiscal_years":[2006,2007,2008,2009],"award_amount_usd":5615704,"org_name":"HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U24CA126563","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 18772890 (this dataset's marker paper) reported under U24CA126563","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA126561","project_num":null,"title":"Cancer Genome Characterization Center at Johns Hopkins","pi_names":["STEPHEN B. BAYLIN"],"agency_ic":"CA","activity_code":"U24","fiscal_years":[2006,2007,2008,2009],"award_amount_usd":2845489,"org_name":"JOHNS HOPKINS UNIVERSITY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U24CA126561","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 18772890 (this dataset's marker paper) reported under U24CA126561","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA126554","project_num":null,"title":"Cancer Genomics Center","pi_names":["Raju S. Kucherlapati"],"agency_ic":"CA","activity_code":"U24","fiscal_years":[2006,2007,2008,2009],"award_amount_usd":6095365,"org_name":"BRIGHAM AND WOMEN'S HOSPITAL","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U24CA126554","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 18772890 (this dataset's marker paper) reported under U24CA126554","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA126551","project_num":null,"title":"The Berkeley Cancer Genome Center","pi_names":["JOE W. GRAY"],"agency_ic":"CA","activity_code":"U24","fiscal_years":[2006,2007,2008,2009],"award_amount_usd":5372086,"org_name":"UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U24CA126551","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 18772890 (this dataset's marker paper) reported under U24CA126551","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA126546","project_num":null,"title":"Center for Cancer Genome Characterization","pi_names":["Matthew L. Meyerson"],"agency_ic":"CA","activity_code":"U24","fiscal_years":[2006,2007,2008,2009],"award_amount_usd":7749871,"org_name":"BROAD INSTITUTE, INC.","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U24CA126546","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 18772890 (this dataset's marker paper) reported under U24CA126546","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA126544","project_num":null,"title":"Cancer Genome Characterization using Gene Expression and DNA Copy Number Analysis","pi_names":["CHARLES M PEROU"],"agency_ic":"CA","activity_code":"U24","fiscal_years":[2006,2007,2008,2009],"award_amount_usd":4916171,"org_name":"UNIV OF NORTH CAROLINA CHAPEL HILL","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U24CA126544","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 18772890 (this dataset's marker paper) reported under U24CA126544","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA126543","project_num":null,"title":"The TCGA Cancer Genome Characterization Center at MSKCC","pi_names":["Marc Ladanyi"],"agency_ic":"CA","activity_code":"U24","fiscal_years":[2006,2007,2008,2009],"award_amount_usd":5106026,"org_name":"SLOAN-KETTERING INST CAN RESEARCH","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U24CA126543","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 18772890 (this dataset's marker paper) reported under U24CA126543","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"R01CA099041","project_num":null,"title":"Genomic & Genetic Characterization of Amplicons in GBMs","pi_names":["LYNDA CHIN"],"agency_ic":"NCI","activity_code":"R01","fiscal_years":[2003,2004,2005,2006,2007],"award_amount_usd":1498974,"org_name":"DANA-FARBER CANCER INST","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=R01CA099041","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 18772890 (this dataset's marker paper) reported under R01CA099041","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]}],"access_steps":[{"order":1,"action":"Download open derived molecular files from the GDC","detail":null,"url":"https://portal.gdc.cancer.gov/projects/TCGA-GBM","requires":[],"est_time":"1 hour","cli_snippet":null,"audience":"human","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908591Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"order":2,"action":"Add imaging from the Imaging Data Commons","detail":"Openly available for the same patients, and the cohort's most under-used asset.","url":"https://portal.imaging.datacommons.cancer.gov/explore/?collection_id=tcga_gbm","requires":[],"est_time":"1-2 hours","cli_snippet":null,"audience":"human","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908591Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"order":3,"action":"Request controlled access only for sequence-level work","detail":null,"url":"https://gdc.cancer.gov/access-data/obtaining-access-controlled-data","requires":["eRA Commons account","institutional signing official approval"],"est_time":"days to a few weeks","cli_snippet":null,"audience":"human","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908591Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"order":4,"action":"Query the project from code, with no credentials","detail":"The file index is public even where files are not, so an agent can size the cohort before anyone requests access.","url":"https://docs.gdc.cancer.gov/API/Users_Guide/Getting_Started/","requires":[],"est_time":null,"cli_snippet":"curl -s 'https://api.gdc.cancer.gov/files' --get \\\n  --data-urlencode 'filters={\"op\":\"in\",\"content\":{\"field\":\"cases.project.project_id\",\"value\":[\"TCGA-GBM\"]}}' \\\n  --data-urlencode 'fields=file_id,file_name,data_type' \\\n  --data-urlencode 'size=10000' --data-urlencode 'format=TSV'","audience":"agent","evidence":[{"method":"derived","source_url":"https://docs.gdc.cancer.gov/API/Users_Guide/Getting_Started/","source_label":"GDC access documentation","retrieved_at":"2026-09-21T12:30:59.429412Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]},{"order":5,"action":"Pass the token when the agent needs controlled files","detail":"Without a token, an API query may return only the open subset. Compare returned counts with the record before treating them as the whole cohort.","url":"https://docs.gdc.cancer.gov/API/Users_Guide/Getting_Started/","requires":["GDC authentication token"],"est_time":null,"cli_snippet":"curl -H \"X-Auth-Token: $GDC_TOKEN\" https://api.gdc.cancer.gov/data/<file_id>","audience":"agent","evidence":[{"method":"derived","source_url":"https://docs.gdc.cancer.gov/API/Users_Guide/Getting_Started/","source_label":"GDC access documentation","retrieved_at":"2026-09-21T12:30:59.429415Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]}],"analysis_examples":[{"level":"advanced","title":"Join the same patients across two NCI repositories","question":"Which cohorts have both imaging and molecular data on the same patients, and how many patients actually carry both?","problem":"Molecular and imaging data for the same cohort live in separate NCI repositories.","lesson":"Join shared patient identifiers and quantify the real multimodal overlap, not the advertised totals.","figure":"Paired horizontal bars per cohort comparing GDC molecular case counts with IDC imaging patient counts, where the shorter bar is the ceiling on a multimodal study of that cohort.","featured":true,"inputs":["Open GDC and IDC APIs, no account required","pandas"],"outputs":["Patient-level intersection between a GDC project and an IDC collection","Counts of molecular-only, imaging-only and joined patients","A map of every cohort present in both repositories","A chart comparing molecular and imaging patient counts per linkable cohort"],"steps":["Retrieve patient identifiers from the GDC project","Query IDC's public SQL endpoint for the collection's patient identifiers","Intersect on the shared barcode and quantify the overlap","Sweep every GDC project against every IDC collection"],"findings":["All 1,098 TCGA-BRCA patients appear in both the GDC and the IDC, a 100% join with nothing imaging-only.","39 cohorts exist in both repositories, covering 15,761 patients.","HCMI-CMDC holds 805 molecular cases but 382 imaging patients, so its multimodal ceiling is 382, not 805."],"contributor":null,"contributor_url":null,"language":"python","est_runtime":"about two minutes","est_compute":null,"workbook_path":"workbooks/python/05_cross_repository_linkage.py","workbook_url":null,"notebook_download_url":"/data/notebooks/05_cross_repository_linkage.ipynb","notebook_preview_url":"/data/notebooks/05_cross_repository_linkage.png","notebook_preview_width":1045,"notebook_preview_height":1045,"colab_url":null,"binder_url":null,"receipt":{"executed":true,"executed_at":"2026-09-21T00:43:01.297366Z","runtime_seconds":4.98,"executor":"nbclient / python 3.12.13 / Darwin 25.5.0 arm64","package_versions":{"python":"3.12.13","pandas":"3.0.6","numpy":"2.5.3","matplotlib":"3.11.2","lifelines":"0.30.0","scipy":"1.18.1","requests":"2.34.2","httpx":"0.28.1"},"n_cells":6,"n_cells_executed":6,"output_hash":"fe7a493665d23ae04c207c4b406923c9","data_retrieved_at":null,"error":null},"template_source":"05_cross_repository_linkage","evidence":[{"method":"curated","source_url":null,"source_label":"CD2S workbook","retrieved_at":"2026-09-21T12:30:59.450353Z","snippet":null,"locator":"workbooks/python/05_cross_repository_linkage.py","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Executed end to end against the live public APIs; the receipt records when, with which package versions and how long it took."}]}],"agent_package":{"json_url":"/data/datasets/gdc-tcga-gbm.json","jsonld_url":"/data/jsonld/gdc-tcga-gbm.jsonld","croissant_url":"/data/croissant/gdc-tcga-gbm.json","instructions_url":"/data/agent/gdc-tcga-gbm.md","bundle_url":null,"mcp_resource_uri":null},"related_dataset_ids":[],"related_underexplored_ids":[],"review":{"status":"project_curated","reviewer":"CD2S project curation","reviewer_affiliation":null,"reviewed_at":"2026-09-18","sections_reviewed":["useful_for","limitations","inappropriate_uses","access_steps"],"open_questions":["The machine-inferred primary publication for this record is a TCGA GBM analysis rather than the cohort's marker paper. Replace with the correct marker citation on next review."],"notes":null},"verification":{"last_verified_at":null,"link_checks":[],"n_links_ok":0,"n_links_broken":0,"upstream_version_seen":null,"upstream_version_changed":false,"upstream_counts_seen":{},"upstream_drift":{},"notes":[]},"is_showcase":true,"completeness_score":100.0,"tags":["gdc","glioma","has-derived-annotations","idc","imaging","imaging-genomics","imaging-pathology","multimodal","reference-cohort","released","tcga"],"search_text":null}