{"id":"gdc-tcga-chol","title":"Cholangiocarcinoma","short_title":"TCGA-CHOL","aliases":["tcga_chol"],"summary":"Cholangiocarcinoma is a cancer that develops in the bile duct. The bile duct is a network of tubes that carry bile from the liver and gallbladder to the small intestine. Tumors that start in bile duct branches that lie inside the liver are called intrahepatic bile duct cancer, while those that form outside the liver are called extrahepatic bile duct cancer. About 10% of all cholangiocarcinoma are intrahepatic and 90% are extrahepatic. TCGA studied both subtypes of cholangiocarcinoma. Although cholangiocarcinoma is a rare cancer, the incidence and mortality rates for the disease have been increasing worldwide in the last three decades. Between 2,000 and 3,000 Americans are diagnosed with cholangiocarcinoma each year, the majority of them with tumors at advanced stages. This cancer is more prevalent in Asia and the Middle East, where parasitic infection of the bile duct increases the risk of cholangiocarcinoma. Other diseases of the bile duct or liver, such as bile duct stones and liver disease, obesity, diabetes, and smoking are also risk factors. When intrahepatic and extrahepatic cholangiocarcinoma spread to other parts of the body, only 2% of patients survive five years after diagnosis. Please see the DICOM converted Slide Microscopy images for the TCGA-CHOL collection page to learn more about the histopathology images and to obtain any supporting metadata for this collection.","one_liner":null,"identifiers":[{"scheme":"gdc_project_id","value":"TCGA-CHOL","url":"https://portal.gdc.cancer.gov/projects/TCGA-CHOL","is_primary":true,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-CHOL?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"gdc_program","value":"TCGA","url":null,"is_primary":false,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-CHOL?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"dbgap_phs","value":"phs000178","url":"https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000178","is_primary":false,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/TCGA-CHOL?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"idc_collection_id","value":"tcga_chol","url":"https://portal.imaging.datacommons.cancer.gov/explore/?collection_id=tcga_chol","is_primary":true,"evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/tcga_chol","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"tcia_collection","value":"TCGA-CHOL","url":"https://www.cancerimagingarchive.net/collections/","is_primary":false,"evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/tcga_chol","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"zenodo","value":"10.5281/zenodo.12689990","url":null,"is_primary":false,"evidence":[{"method":"fulltext","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/tcga_chol","source_label":"IDC collection description","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":"s after diagnosis. Please see the DICOM converted Slide Microscopy images for the TCGA-CHOL collection page to learn more about the histopathology images and to obtain any supporting metadata for th","locator":"accession extracted from description prose","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Cross-repository link recovered from prose; verify before relying on it."}]}],"repository":{"name":"NCI Genomic Data Commons","short_name":"GDC","url":"https://portal.gdc.cancer.gov","is_nci_crdc_node":true,"is_nih_repository":true},"additional_repositories":[{"name":"NCI Imaging Data 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This is a lower bound on availability."}]},"underexplored":{"is_underexplored":false,"basis":["Reuse is within the expected range for comparable datasets (index +1.51)."],"index_value":1.507,"percentile":84.8,"comparator_set":"132 datasets in this corpus with a citable accession and sufficient metadata","evidence":[{"method":"derived","source_url":null,"source_label":"Reuse Gap Index (rgi-huber-v2)","retrieved_at":"2026-09-21T02:11:22.976067Z","snippet":null,"locator":"Huber robust regression of log2(analyzing articles + 1) on cohort size, years available, modality breadth and access tier","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Model, covariates and coefficients are published with the dataset export so the label can be recomputed or contested."}]},"grants":[{"core_project_num":"U24CA210990","project_num":null,"title":"UCSC-Buck Specialized Genomic Data Analysis Center for the Genomic Data Analysis Network","pi_names":["JOSHUA Michael STUART"],"agency_ic":"CA","activity_code":"U24","fiscal_years":[2016,2017,2018,2019,2020],"award_amount_usd":2181795,"org_name":"UNIVERSITY OF CALIFORNIA SANTA CRUZ","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U24CA210990","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 28297679 (this dataset's marker paper) reported under U24CA210990","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. 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Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA143882","project_num":null,"title":"The USC-JHU Cancer Epigenome Characterization Center","pi_names":["STEPHEN B. 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Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA143867","project_num":null,"title":"Genome Characterization Center (GCC)","pi_names":["Stacey Gabriel","Matthew L. 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Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA143866","project_num":null,"title":"Cancer transcriptome characterization using massively parallel DNA sequencing","pi_names":["Marco Antonio Marra"],"agency_ic":"CA","activity_code":"U24","fiscal_years":[2009,2010,2011,2012,2013,2014,2015],"award_amount_usd":10876224,"org_name":"BRITISH COLUMBIA CANCER AGENCY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U24CA143866","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 28297679 (this dataset's marker paper) reported under U24CA143866","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA143858","project_num":null,"title":"UCSC-Buck Inst. 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Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA143848","project_num":null,"title":"Gene Expression Patterns in Human Tumors Identified Using Transcript Sequencing","pi_names":["David N Hayes","CHARLES M PEROU"],"agency_ic":"CA","activity_code":"U24","fiscal_years":[2009,2010,2011,2012,2013,2014,2016],"award_amount_usd":20842970,"org_name":"UNIV OF NORTH CAROLINA CHAPEL HILL","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U24CA143848","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 28297679 (this dataset's marker paper) reported under U24CA143848","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA143845","project_num":null,"title":"The Cancer Genome Atlas Data Analysis Center","pi_names":["LYNDA CHIN","GAD A GETZ"],"agency_ic":"CA","activity_code":"U24","fiscal_years":[2009,2010,2011,2012,2013,2014,2016],"award_amount_usd":15987999,"org_name":"BROAD INSTITUTE, INC.","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U24CA143845","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 28297679 (this dataset's marker paper) reported under U24CA143845","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. 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Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA143840","project_num":null,"title":"MSKCC Center for Translational Cancer Genomic Analysis","pi_names":["Marc Ladanyi","CHRIS SANDER"],"agency_ic":"CA","activity_code":"U24","fiscal_years":[2009,2010,2011,2012,2013,2014,2016],"award_amount_usd":11508790,"org_name":"SLOAN-KETTERING INST CAN RESEARCH","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U24CA143840","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 28297679 (this dataset's marker paper) reported under U24CA143840","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA143835","project_num":null,"title":"Center for Systems Analysis of the Cancer Regulome","pi_names":["ILYA SHMULEVICH"],"agency_ic":"CA","activity_code":"U24","fiscal_years":[2009,2010,2011,2012,2013,2014,2016],"award_amount_usd":10612504,"org_name":"INSTITUTE FOR SYSTEMS BIOLOGY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U24CA143835","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 28297679 (this dataset's marker paper) reported under U24CA143835","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"U24CA143799","project_num":null,"title":"TCGA Data Analysis Center at Berkeley","pi_names":["PAUL T. 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Resolved from RePORTER's publication index; only a repository-supplied or reviewer-supplied marker paper is used, never one this pipeline nominated itself."}]},{"core_project_num":"R01CA180778","project_num":null,"title":"BIGDATA: Mid-Scale DCM: DA: ESCE: Discovering Molecular Processes","pi_names":["JOSHUA Michael STUART"],"agency_ic":"NCI","activity_code":"R01","fiscal_years":[2013,2014,2015,2016,2017],"award_amount_usd":3530894,"org_name":"UNIVERSITY OF CALIFORNIA SANTA CRUZ","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=R01CA180778","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:21:14.041075Z","snippet":null,"locator":"PMID 28297679 (this dataset's marker paper) reported under R01CA180778","confidence":"high","reviewer":null,"reviewed_at":null,"note":"The award is credited on the dataset's own marker paper, so it paid to produce these data rather than to analyse them. 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It is not a reviewer's account of this dataset."}]}],"analysis_examples":[],"agent_package":{"json_url":"/data/datasets/gdc-tcga-chol.json","jsonld_url":"/data/jsonld/gdc-tcga-chol.jsonld","croissant_url":"/data/croissant/gdc-tcga-chol.json","instructions_url":"/data/agent/gdc-tcga-chol.md","bundle_url":null,"mcp_resource_uri":null},"related_dataset_ids":[],"related_underexplored_ids":[],"review":{"status":"machine_only","reviewer":null,"reviewer_affiliation":null,"reviewed_at":null,"sections_reviewed":[],"open_questions":[],"notes":null},"verification":{"last_verified_at":null,"link_checks":[],"n_links_ok":0,"n_links_broken":0,"upstream_version_seen":null,"upstream_version_changed":false,"upstream_counts_seen":{},"upstream_drift":{},"notes":[]},"is_showcase":false,"completeness_score":42.9,"tags":["gdc","idc","imaging","released","tcga"],"search_text":null}