{"id":"gdc-mp2prt-all","title":"Molecular Profiling to Predict Response to Treatment for Acute Lymphoblastic Leukemia","short_title":"MP2PRT-ALL","aliases":["MP2PRT-ALL"],"summary":"MP2PRT-ALL is the strongest treatment-response resource in this corpus, and it is not widely known. Every one of the 1,510 patients has a populated treatment outcome, a named regimen or line of therapy, and a progression status at follow-up - 100% coverage on all three, which is rarer than it sounds. Median follow-up is 100.2 months with a maximum of 180.8, the longest realised follow-up of any cohort indexed here. Whole genome sequencing covers 1,507 cases, exome 1,494 and RNA sequencing 1,479.\nBecause the cohort is drawn from cooperative-group trials, the treatment is protocolised rather than heterogeneous, which removes the confounding that usually defeats treatment-response analysis in observational cohorts. 333 of 1,510 patients are recorded as Hispanic or Latino, a group with documented excess ALL incidence and inferior outcomes and one that is under-represented in most genomic cohorts.","one_liner":"1,510 children with acute lymphoblastic leukaemia from Children's Oncology Group trials, with whole genome sequencing, 8.4 years of median follow-up, and a named treatment regimen and response recorded for every single case.","identifiers":[{"scheme":"gdc_project_id","value":"MP2PRT-ALL","url":"https://portal.gdc.cancer.gov/projects/MP2PRT-ALL","is_primary":true,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/MP2PRT-ALL?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"gdc_program","value":"MP2PRT","url":null,"is_primary":false,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/MP2PRT-ALL?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"dbgap_phs","value":"phs002005","url":"https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs002005","is_primary":false,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/MP2PRT-ALL?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]}],"repository":{"name":"NCI Genomic Data Commons","short_name":"GDC","url":"https://portal.gdc.cancer.gov","is_nci_crdc_node":true,"is_nih_repository":true},"additional_repositories":[],"program_name":"MP2PRT","program_url":"https://portal.gdc.cancer.gov/analysis_page?app=Projects","nci_program":"MP2PRT","generating_institutions":[],"data_generation_funding_role":"generation","version":null,"release_date":"2025-01-01","last_upstream_update":null,"retrieved_at":"2026-09-18T02:35:42.169383Z","landing_page_url":"https://portal.gdc.cancer.gov/projects/MP2PRT-ALL","cancer_types":[{"label":"Acute Lymphoblastic Leukemia","ontology":null,"code":null,"url":null},{"label":"Lymphoid Leukemias","ontology":null,"code":null,"url":null}],"primary_sites":["Hematopoietic and reticuloendothelial systems"],"subject":{"scope":"single","tissues":["LYMPH"],"evidence":[{"method":"derived","source_url":null,"source_label":"cds.subjects","retrieved_at":null,"snippet":null,"locator":"cancer_types: Acute Lymphoblastic Leukemia, Lymphoid Leukemias; primary_sites: Hematopoietic and reticuloendothelial systems","confidence":"high","reviewer":null,"reviewed_at":null,"note":"A two-thirds histology majority determined the subject."}]},"is_pediatric":null,"model_systems":[],"cohort":{"n_cases":1510,"n_samples":null,"n_aliquots":null,"n_files":60831,"total_bytes":595222092129654,"n_tumor_cases":null,"n_normal_cases":null,"has_matched_normal":null,"demographics":{"sex":{"male":850,"female":660},"race":{"white":1169,"unknown":190,"black or african american":89,"asian":54,"american indian or alaska native":6,"native hawaiian or other pacific islander":2},"ethnicity":{"not hispanic or latino":1128,"hispanic or latino":333,"unknown":49},"age_at_diagnosis_years":{"n":1510.0,"min":1.0,"q1":2.9,"median":4.1,"q3":5.9,"max":29.2},"vital_status":{"alive":1133,"unknown":241,"dead":136},"country_or_region":{"united states":1351,"canada":95,"australia":37,"new zealand":15,"switzerland":8,"dominican republic":2,"albania":1,"bahamas":1},"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"demographic.*","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/MP2PRT-ALL?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"assays":[{"modality":"wxs","label":"Whole exome sequencing","platform":"illumina","n_cases":1494,"n_samples":null,"n_files":23471,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/MP2PRT-ALL?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"rna_seq","label":"Bulk RNA sequencing","platform":"illumina","n_cases":1479,"n_samples":null,"n_files":13311,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/MP2PRT-ALL?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"wgs","label":"Whole genome sequencing","platform":"illumina","n_cases":1507,"n_samples":null,"n_files":24046,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/MP2PRT-ALL?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"clinical","label":"Clinical","platform":null,"n_cases":1510,"n_samples":null,"n_files":3,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/MP2PRT-ALL?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"copy_number","label":"Copy Number Variation","platform":null,"n_cases":1504,"n_samples":null,"n_files":5994,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/MP2PRT-ALL?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"structural_variant","label":"Somatic Structural Variation","platform":null,"n_cases":1504,"n_samples":null,"n_files":6019,"data_levels":[],"access_tier":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/MP2PRT-ALL?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]}],"clinical_variables":[{"name":"demographic.sex_at_birth","harmonized_name":"demographic.sex_at_birth","label":"Sex at birth","category":"demographic","n_nonmissing":1510,"n_not_reported":0,"n_informative":1510,"n_total":1510,"coverage_pct":100.0,"populated_pct":100.0,"is_repeated":false,"example_values":["male","female"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: demographic.sex_at_birth","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"demographic.race","harmonized_name":"demographic.race","label":"Race","category":"demographic","n_nonmissing":1510,"n_not_reported":190,"n_informative":1320,"n_total":1510,"coverage_pct":87.4,"populated_pct":100.0,"is_repeated":false,"example_values":["white","unknown","black or african american","asian","american indian or alaska native","native hawaiian or other pacific islander"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: demographic.race","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"demographic.ethnicity","harmonized_name":"demographic.ethnicity","label":"Ethnicity","category":"demographic","n_nonmissing":1510,"n_not_reported":49,"n_informative":1461,"n_total":1510,"coverage_pct":96.8,"populated_pct":100.0,"is_repeated":false,"example_values":["not hispanic or latino","hispanic or latino","unknown"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: demographic.ethnicity","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"demographic.vital_status","harmonized_name":"demographic.vital_status","label":"Vital status","category":"outcome","n_nonmissing":1510,"n_not_reported":241,"n_informative":1269,"n_total":1510,"coverage_pct":84.0,"populated_pct":100.0,"is_repeated":false,"example_values":["alive","unknown","dead"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: demographic.vital_status","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"demographic.cause_of_death","harmonized_name":"demographic.cause_of_death","label":"Cause of death","category":"outcome","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: demographic.cause_of_death","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"demographic.population_group","harmonized_name":"demographic.population_group","label":"Population group","category":"demographic","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: demographic.population_group","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"demographic.country_of_residence_at_enrollment","harmonized_name":"demographic.country_of_residence_at_enrollment","label":"Country of residence","category":"demographic","n_nonmissing":1510,"n_not_reported":0,"n_informative":1510,"n_total":1510,"coverage_pct":100.0,"populated_pct":100.0,"is_repeated":false,"example_values":["united states","canada","australia","new zealand","switzerland","dominican republic"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: demographic.country_of_residence_at_enrollment","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.primary_diagnosis","harmonized_name":"diagnoses.primary_diagnosis","label":"Primary diagnosis","category":"diagnosis","n_nonmissing":1510,"n_not_reported":1,"n_informative":1509,"n_total":1510,"coverage_pct":99.9,"populated_pct":100.0,"is_repeated":false,"example_values":["common precursor b all","acute lymphoblastic leukemia, nos","leukemia, nos","acute leukemia, nos","precursor b-cell lymphoblastic leukemia","precursor cell lymphoblastic leukemia, nos"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.primary_diagnosis","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.morphology","harmonized_name":"diagnoses.morphology","label":"Morphology (ICD-O)","category":"pathology","n_nonmissing":1510,"n_not_reported":154,"n_informative":1356,"n_total":1510,"coverage_pct":89.8,"populated_pct":100.0,"is_repeated":false,"example_values":["9836/3","unknown","9800/3","9728/3","9801/3","9835/3"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.morphology","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.tissue_or_organ_of_origin","harmonized_name":"diagnoses.tissue_or_organ_of_origin","label":"Tissue or organ of origin","category":"diagnosis","n_nonmissing":1510,"n_not_reported":0,"n_informative":1510,"n_total":1510,"coverage_pct":100.0,"populated_pct":100.0,"is_repeated":false,"example_values":["bone marrow","blood"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.tissue_or_organ_of_origin","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.ajcc_pathologic_stage","harmonized_name":"diagnoses.ajcc_pathologic_stage","label":"AJCC pathologic stage","category":"staging","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.ajcc_pathologic_stage","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.ajcc_clinical_stage","harmonized_name":"diagnoses.ajcc_clinical_stage","label":"AJCC clinical stage","category":"staging","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.ajcc_clinical_stage","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.tumor_grade","harmonized_name":"diagnoses.tumor_grade","label":"Tumor grade","category":"pathology","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.tumor_grade","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.prior_treatment","harmonized_name":"diagnoses.prior_treatment","label":"Prior treatment","category":"treatment","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.prior_treatment","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.prior_malignancy","harmonized_name":"diagnoses.prior_malignancy","label":"Prior malignancy","category":"diagnosis","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.prior_malignancy","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.synchronous_malignancy","harmonized_name":"diagnoses.synchronous_malignancy","label":"Synchronous malignancy","category":"diagnosis","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.synchronous_malignancy","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.progression_or_recurrence","harmonized_name":"diagnoses.progression_or_recurrence","label":"Progression or recurrence","category":"outcome","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.progression_or_recurrence","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.last_known_disease_status","harmonized_name":"diagnoses.last_known_disease_status","label":"Last known disease status","category":"outcome","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.last_known_disease_status","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.classification_of_tumor","harmonized_name":"diagnoses.classification_of_tumor","label":"Classification of tumor","category":"pathology","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.classification_of_tumor","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.treatments.treatment_type","harmonized_name":"diagnoses.treatments.treatment_type","label":"Treatment type","category":"treatment","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.treatments.treatment_type","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.treatments.treatment_or_therapy","harmonized_name":"diagnoses.treatments.treatment_or_therapy","label":"Treatment given","category":"treatment","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.treatments.treatment_or_therapy","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.treatments.therapeutic_agents","harmonized_name":"diagnoses.treatments.therapeutic_agents","label":"Therapeutic agents","category":"treatment","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.treatments.therapeutic_agents","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.treatments.treatment_outcome","harmonized_name":"diagnoses.treatments.treatment_outcome","label":"Treatment outcome","category":"treatment","n_nonmissing":1510,"n_not_reported":0,"n_informative":1510,"n_total":1510,"coverage_pct":100.0,"populated_pct":100.0,"is_repeated":false,"example_values":["complete response","partial response"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.treatments.treatment_outcome","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"diagnoses.treatments.regimen_or_line_of_therapy","harmonized_name":"diagnoses.treatments.regimen_or_line_of_therapy","label":"Regimen or line of therapy","category":"treatment","n_nonmissing":1510,"n_not_reported":0,"n_informative":1510,"n_total":1510,"coverage_pct":100.0,"populated_pct":100.0,"is_repeated":false,"example_values":["b-all non-down syndrome  induction therapy","standard induction - all patients in all groups","sr-low group - lrs arm:  standard consolidation, standard interim maintenance, standard delayed inte","b-all average risk - arm b maintenance therapy","b-all average risk post-induction/pre-maintenance therapy","sr-high group - high arm:  intensified consolidation, augmented interim maintenance, augmented delay"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: diagnoses.treatments.regimen_or_line_of_therapy","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"follow_ups.disease_response","harmonized_name":"follow_ups.disease_response","label":"Disease response at follow-up","category":"followup","n_nonmissing":1510,"n_not_reported":0,"n_informative":1510,"n_total":1510,"coverage_pct":100.0,"populated_pct":100.0,"is_repeated":false,"example_values":["cr-complete response","pr-partial response"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: follow_ups.disease_response","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"follow_ups.progression_or_recurrence","harmonized_name":"follow_ups.progression_or_recurrence","label":"Progression at follow-up","category":"followup","n_nonmissing":1510,"n_not_reported":0,"n_informative":1510,"n_total":1510,"coverage_pct":100.0,"populated_pct":100.0,"is_repeated":false,"example_values":["no","yes"],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: follow_ups.progression_or_recurrence","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"follow_ups.ecog_performance_status","harmonized_name":"follow_ups.ecog_performance_status","label":"ECOG performance status","category":"followup","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: follow_ups.ecog_performance_status","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"exposures.tobacco_smoking_status","harmonized_name":"exposures.tobacco_smoking_status","label":"Tobacco smoking status","category":"exposure","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: exposures.tobacco_smoking_status","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"exposures.alcohol_history","harmonized_name":"exposures.alcohol_history","label":"Alcohol history","category":"exposure","n_nonmissing":0,"n_not_reported":0,"n_informative":0,"n_total":1510,"coverage_pct":0.0,"populated_pct":0.0,"is_repeated":false,"example_values":[],"unit":null,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&facets=demographic.sex_at_birth%2Cdemographic.race%2Cdemographic.ethnicity%2Cdemographic.vital_status%2Cdemographic.cause_of_death%2Cdemographic.population_group%2Cdemographic.country_of_residence_at_enrollment%2Cdiagnoses.primary_diagnosis%2Cdiagnoses.morphology%2Cdiagnoses.tissue_or_organ_of_origin%2Cdiagnoses.ajcc_pathologic_stage%2Cdiagnoses.ajcc_clinical_stage%2Cdiagnoses.tumor_grade%2Cdiagnoses.prior_treatment%2Cdiagnoses.prior_malignancy%2Cdiagnoses.synchronous_malignancy%2Cdiagnoses.progression_or_recurrence%2Cdiagnoses.last_known_disease_status%2Cdiagnoses.classification_of_tumor%2Cdiagnoses.treatments.treatment_type%2Cdiagnoses.treatments.treatment_or_therapy%2Cdiagnoses.treatments.therapeutic_agents%2Cdiagnoses.treatments.treatment_outcome%2Cdiagnoses.treatments.regimen_or_line_of_therapy%2Cfollow_ups.disease_response%2Cfollow_ups.progression_or_recurrence%2Cfollow_ups.ecog_performance_status%2Cexposures.tobacco_smoking_status%2Cexposures.alcohol_history&size=0","source_label":"GDC API /cases facets","retrieved_at":"2026-09-18T02:35:39.505371Z","snippet":null,"locator":"facet: exposures.alcohol_history","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]}],"longitudinal":{"has_followup":true,"has_survival_endpoint":true,"survival_endpoints":["overall survival"],"median_followup_months":100.2,"max_followup_months":180.8,"n_cases_with_followup":1510,"has_serial_samples":null,"timepoints":[],"n_cases_with_serial":null,"has_treatment_response":true,"response_criteria":["complete response","cr-complete response","partial response","pr-partial response"],"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/cases?filters=%7B%22content%22%3A+%7B%22field%22%3A+%22project.project_id%22%2C+%22value%22%3A+%5B%22MP2PRT-ALL%22%5D%7D%2C+%22op%22%3A+%22in%22%7D&fields=diagnoses.age_at_diagnosis%2Cdiagnoses.days_to_last_follow_up%2Cdiagnoses.days_to_recurrence%2Cdemographic.days_to_death%2Cdemographic.vital_status%2Cfollow_ups.days_to_follow_up%2Cfollow_ups.days_to_progression%2Cdiagnoses.treatments.days_to_treatment_start&size=1510&format=json","source_label":"GDC API /cases (case-level fields)","retrieved_at":"2026-09-18T02:35:41.651801Z","snippet":null,"locator":"computed from 1510 cases; follow-up time derivable for 1510 of them","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"access":{"tier":"mixed","open_components":["7,459 open-access files"],"controlled_components":["53,372 controlled-access files"],"mechanism":"Data Access Request through dbGaP using an eRA Commons account; institutional signing official approval required","dua_url":"https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs002005","data_access_committee":"NCI Data Access Committee","typical_turnaround":"days to a few weeks after signing official approval","embargo_until":null,"login_required":true,"citation_requirement":"Cite the dataset accession and the program's publication guidelines; see the GDC publication policy.","license":"NIH Genomic Data Sharing Policy terms","publication_policy_url":"https://gdc.cancer.gov/about-data/publications","evidence":[]},"useful_for":[{"question":"Which genomic features predict failure of protocolised induction therapy in paediatric B-cell acute lymphoblastic leukaemia?","rationale":"Treatment outcome and regimen are populated for 100% of 1,510 cases, and regimen strings name the actual protocol arm, so response can be modeled within a treatment context rather than across an uncontrolled mixture of therapies. Whole genome sequencing on 1,507 cases supports genome-wide discovery at this sample size.","required_fields":["diagnoses.treatments.treatment_outcome","diagnoses.treatments.regimen_or_line_of_therapy"],"required_modalities":["wgs","rna_seq","treatment"],"feasibility":"needs_access","approx_n":1510,"statistical_note":"Complete response is the dominant outcome category in a curable disease, so the informative contrast is relapse and residual disease rather than induction failure. Expect a heavily imbalanced outcome and plan the design accordingly.","exemplar_pmid":null,"topics":["treatment-response","paediatric-oncology","leukaemia"],"evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908261Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"question":"Do Hispanic or Latino children carry a different genomic landscape or a different response profile, and does genomics explain any of the known outcome disparity?","rationale":"333 of 1,510 patients are recorded as Hispanic or Latino - both a substantial absolute number and a substantial share, which is unusual. With treatment held closer to constant by the trial protocol, the ethnicity contrast is less confounded by care access than in an observational cohort.","required_fields":["demographic.ethnicity","diagnoses.treatments.treatment_outcome"],"required_modalities":["wgs","rna_seq","treatment"],"feasibility":"needs_access","approx_n":1461,"statistical_note":"Ethnicity is self-reported and unknown for 49 cases. Genetic ancestry can be estimated from the germline data and is the more defensible variable for biological claims; report both and do not treat them as interchangeable.","exemplar_pmid":null,"topics":["health-disparities","paediatric-oncology","treatment-response"],"evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908261Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"question":"What are the long-term survival determinants in paediatric ALL, given follow-up that extends beyond fifteen years?","rationale":"Vital status is informative for 84% of cases and median follow-up is 100.2 months, so late relapse and long-term survival are genuinely observable rather than censored away. Very few genomic cohorts of this size reach this follow-up duration.","required_fields":["demographic.vital_status","diagnoses.days_to_last_follow_up"],"required_modalities":["clinical","outcome","wgs"],"feasibility":"needs_access","approx_n":1268,"statistical_note":"16% of cases have uninformative vital status; check whether missingness is associated with treatment arm before assuming it is uninformative censoring.","exemplar_pmid":null,"topics":["survival","paediatric-oncology"],"evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908261Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"question":"How do subtype-defining fusions and copy number alterations interact with assigned risk group and delivered therapy?","rationale":"Structural variant and copy number calls exist for 1,504 cases, and the regimen field records the risk-stratified arm each patient received, allowing molecular subtype to be crossed with the therapy actually delivered.","required_fields":[],"required_modalities":["structural_variant","copy_number","treatment"],"feasibility":"needs_access","approx_n":1504,"statistical_note":null,"exemplar_pmid":null,"topics":["molecular-subtypes","risk-stratification"],"evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908261Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]}],"limitations":[{"kind":"missing_data","statement":"Despite complete treatment-outcome coverage, the descriptive treatment fields are empty: treatment type, treatment given and therapeutic agents are all at 0%. The regimen field names the protocol arm, so the therapy is recoverable from trial documentation, but individual drug exposures are not recorded per patient here.","severity":"major","affected_analyses":["Drug-specific exposure analysis","Cumulative dose analysis"],"mitigation":"Map the regimen strings onto the published COG protocol definitions to recover drug composition, and state that mapping explicitly in your methods.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908261Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"kind":"missing_data","statement":"Cause of death is not recorded for any case, so competing risks cannot be separated.","severity":"major","affected_analyses":["Competing-risk models","Treatment-related mortality"],"mitigation":"Restrict to overall survival, or obtain cause of death through the trial group.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908261Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"kind":"ascertainment_bias","statement":"Participants are enrolled on cooperative-group trials, which select for access to a participating center and for eligibility criteria that exclude some patients. Outcomes in trial populations are generally better than in the wider patient population.","severity":"major","affected_analyses":["Population-level outcome estimates","Generalization to non-trial patients"],"mitigation":"Frame results as applying to trial-enrolled patients.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908261Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"kind":"population_coverage","statement":"Race is unknown for 190 of 1,510 cases, and Black or African American patients number 89, which limits race-stratified analysis even though ethnicity coverage is good.","severity":"minor","affected_analyses":["Race-stratified subgroup analysis"],"mitigation":"Prefer genetic ancestry estimated from the germline data for biological claims.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908261Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"kind":"access_constraint","statement":"53,372 of 60,831 files are controlled access.","severity":"major","affected_analyses":["Any sequence-level analysis"],"mitigation":"Begin the dbGaP request early.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908261Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]}],"inappropriate_uses":[{"statement":"Estimating paediatric ALL incidence or population survival.","reason":"This is a trial-enrolled cohort with no population denominator.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908261Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"statement":"Comparing specific chemotherapy agents head to head.","reason":"Per-patient drug exposure is not recorded; only the protocol arm is. Agent-level claims would rest on assumptions about protocol adherence rather than on data.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908261Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]}],"primary_publications":[],"reuse":[{"publication":{"pmid":"39880832","pmcid":"PMC11779914","doi":"10.1038/s41467-025-56229-7","title":"Molecular and pharmacological heterogeneity of ETV6::RUNX1 acute lymphoblastic leukemia.","journal":"Nature communications","year":2025,"authors_short":"Li et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/39880832/","is_open_access":true,"citation_count":16,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":null,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"DATA_AVAILABILITY, SUPPL","author_keys":["antillon-klussmann f","brady s","brown a","chang t","cheng c","choi l","crews k","evans w","gocho y","hsiao y","huang x","inaba h","jeha s","karol s","loh m","maillard m","mullighan c","pui c","rowland l","yang j","yang w","yeoh a","yoshimura s","zhao h"],"nci_funded_reuse":true,"linked_grants":["U01CA264610","R01CA264837","P30CA021765"],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DATA_AVAILABILITY:\"MP2PRT-ALL\"","source_label":"Europe PMC section search (DATA_AVAILABILITY)","retrieved_at":"2026-09-18T03:17:26.365995Z","snippet":null,"locator":"accession \"MP2PRT-ALL\" indexed in DATA_AVAILABILITY","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"42383304","pmcid":"PMC13428383","doi":"10.1002/ajh.70432","title":"Relapse Thresholds (12/24 Mo) Define Survival Disparity in Pediatric B-ALL.","journal":"American journal of hematology","year":2026,"authors_short":"Xiong et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/42383304/","is_open_access":false,"citation_count":0,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":null,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"METHODS","author_keys":["cheng j","feng y","shen y","shi h","tang w","xiong b","you h","zhang x","zhou f","zhou j"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=METHODS:\"MP2PRT-ALL\"","source_label":"Europe PMC section search (METHODS)","retrieved_at":"2026-09-18T03:17:26.365995Z","snippet":null,"locator":"accession \"MP2PRT-ALL\" indexed in METHODS","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"41802009","pmcid":"PMC13085861","doi":"10.1158/2767-9764.crc-25-0706","title":"Pseudogene Coexpression Networks Reveal a Robust Prognostic Signature for Pediatric B-ALL Survival.","journal":"Cancer research communications","year":2026,"authors_short":"Nakamura-García et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/41802009/","is_open_access":true,"citation_count":0,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":null,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"DATA_AVAILABILITY, METHODS","author_keys":["espinal-enríquez j","kuijjer m","nakamura-garcía a"],"nci_funded_reuse":false,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DATA_AVAILABILITY:\"MP2PRT-ALL\"","source_label":"Europe PMC section search (DATA_AVAILABILITY)","retrieved_at":"2026-09-18T03:17:26.365995Z","snippet":null,"locator":"accession \"MP2PRT-ALL\" indexed in DATA_AVAILABILITY","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":"41587071","pmcid":"PMC13077480","doi":"10.1182/blood.2025031289","title":"Uncovering the genomic complexity of PAX5 intragenic tandem multiplication via long-read and short-read sequencing.","journal":"Blood","year":2026,"authors_short":"Liu et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/41587071/","is_open_access":true,"citation_count":0,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":null,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"SUPPL","author_keys":["bennett d","brady s","briviba m","brown p","carroll w","chang t","chen w","deardorff c","dong l","easton j","eckert a","fan l","feng y","geeleher p","jones t","kolekar p","liu y","loh m","loyd m","mcbride a","meshinchi s","mulder h","mullighan c","neale g","plyler e","pounds s","ries r","yang j","zhang j","zhao h"],"nci_funded_reuse":true,"linked_grants":["U10CA180899","U10CA180886","R01CA273326"],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=SUPPL:\"MP2PRT-ALL\"","source_label":"Europe PMC section search (SUPPL)","retrieved_at":"2026-09-18T03:17:26.365995Z","snippet":null,"locator":"accession \"MP2PRT-ALL\" indexed in SUPPL","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":null,"pmcid":null,"doi":"10.1101/2025.09.12.675799","title":"Increased activity of PRMT5-MEP50 complex improves survival of chromosomally unstable cancer cells by increasing tolerance to protein aggregation and proteotoxicity","journal":null,"year":2025,"authors_short":"Suarez et al.","n_authors":null,"url":"https://doi.org/10.1101/2025.09.12.675799","is_open_access":true,"citation_count":0,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":null,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"RESULTS","author_keys":["bakker p","foijer f","gaviria a","heberle a","hong c","jilderda l","lavoie g","oeckinghaus a","roorda m","roux p","simon j","suarez p","thedieck k","van k","van v"],"nci_funded_reuse":null,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=RESULTS:\"MP2PRT-ALL\"","source_label":"Europe PMC section search (RESULTS)","retrieved_at":"2026-09-18T03:17:26.365995Z","snippet":null,"locator":"accession \"MP2PRT-ALL\" indexed in RESULTS","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]},{"publication":{"pmid":null,"pmcid":null,"doi":"10.64898/2025.12.22.695871","title":"Three-Dimensional Epigenome Roadmap of Human B-cell Differentiation Uncovers Mechanisms of Humoral Immunity and Oncogenesis","journal":null,"year":2025,"authors_short":"de et al.","n_authors":null,"url":"https://doi.org/10.64898/2025.12.22.695871","is_open_access":true,"citation_count":0,"evidence":[]},"tier":"t3_analyzed","kind":"secondary_analysis","independent_of_generators":null,"what_they_analyzed":null,"what_they_found":null,"methods_summary":null,"modalities_used":[],"accession_snippet":null,"accession_locator":"FIG","author_keys":["alqahtani a","amilibia e","brittain n","byrne-álvarez n","carbonell j","costa a","falcon-bermejo j","fanlo-escudero l","guerrero-gilabert m","javierre b","kulis m","lópez-martí p","martin-subero j","medvedeva g","ochoteco j","planas-riverola a","pérez s","rico d","rigau m","robert-finestra t","rovirosa l","rusell l","tomás-daza l","urmeneta b","valencia a","valero-martínez b","álvarez-gonzález l"],"nci_funded_reuse":null,"linked_grants":[],"adjudicated_by":null,"adjudicated_at":null,"evidence":[{"method":"fulltext","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=FIG:\"MP2PRT-ALL\"","source_label":"Europe PMC section search (FIG)","retrieved_at":"2026-09-18T03:17:26.365995Z","snippet":null,"locator":"accession \"MP2PRT-ALL\" indexed in FIG","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Search strategy epmc-sectioned-v1. Section placement is used to grade the strength of reuse evidence, not merely to confirm a citation."}]}],"reuse_metrics":{"n_candidates_screened":1,"n_by_tier":{"t3_analyzed":0,"t2_declared":1,"t1_accession":0,"t0_mention":0},"n_by_tier_raw":{"t3_analyzed":0,"t2_declared":1,"t1_accession":0,"t0_mention":0},"accession_precision":{"token":"phs002005","query":"METHODS:\"phs002005\"","strategy_id":"epmc-literal-precision-v1","needs_correction":false,"precision":1.0,"precision_low":1.0,"precision_high":1.0,"n_sampled":0,"n_checked":0,"n_literal":0,"note":"This accession is a single indexed term, so Europe PMC matches it exactly and the hit count needs no correction."},"n_citations_to_primary_publication":null,"citation_to_reuse_ratio":null,"has_citable_accession":true,"n_verified_reuse":0,"n_reuse_examined":6,"n_independent_reuse":0,"n_nci_funded_reuse":2,"first_reuse_year":2025,"latest_reuse_year":2026,"years_since_release":1.72,"expected_reuse":4.17,"reuse_gap_index":-2.371,"reuse_gap_percentile":6.8,"search_strategy_id":"epmc-index-v3","searched_at":"2026-09-20T18:07:30.799911Z","no_reuse_identified":false,"evidence":[{"method":"derived","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search","source_label":"Europe PMC section-scoped hit counts","retrieved_at":"2026-09-20T18:07:30.799911Z","snippet":null,"locator":"tokens: MP2PRT-ALL, phs002005; queries: METHODS:\"phs002005\"; DATA_AVAILABILITY:\"phs002005\"; ACCESSION_ID:\"phs002005\"; REF:\"phs002005\"","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Index strategy epmc-index-v3. Every dataset is measured with the same single section field per tier, so the counts are comparable; the per-tier value is the largest across the dataset's own accessions, excluding any accession shared with other datasets in the corpus. This accession is a single indexed term, so Europe PMC matches it exactly and the hit count needs no correction."},{"method":"derived","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search","source_label":"Europe PMC first-reference dating","retrieved_at":"2026-09-20T18:08:25.178881Z","snippet":null,"locator":"first referenced in 2025 (DATA_AVAILABILITY section)","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Availability dated from the literature (epmc-first-reference-v2) rather than from repository file timestamps, which record re-harmonization. This is a lower bound on availability."}]},"underexplored":{"is_underexplored":true,"basis":["0 article(s) reference this dataset's accession in a methods section, against 4.2 predicted for datasets of comparable size, age, modality breadth and access tier (reuse gap index -2.37 on a log2 scale, 7th percentile of the assessed corpus)."],"index_value":-2.371,"percentile":6.8,"comparator_set":"132 datasets in this corpus with a citable accession and sufficient metadata","evidence":[{"method":"derived","source_url":null,"source_label":"Reuse Gap Index (rgi-huber-v2)","retrieved_at":"2026-09-21T02:11:22.976067Z","snippet":null,"locator":"Huber robust regression of log2(analyzing articles + 1) on cohort size, years available, modality breadth and access tier","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Model, covariates and coefficients are published with the dataset export so the label can be recomputed or contested."}]},"grants":[{"core_project_num":"U01CA264610","project_num":null,"title":"Clonal Therapy for Pediatric T-cell Acute Lymphoblastic Leukemia","pi_names":["Jun J. Yang","Jiyang Yu"],"agency_ic":"NCI","activity_code":"U01","fiscal_years":[2021,2022,2023,2024,2025],"award_amount_usd":2776588,"org_name":"ST. JUDE CHILDREN'S RESEARCH HOSPITAL","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U01CA264610","role":"infrastructure","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:43:19.296398Z","snippet":null,"locator":"PMID 39880832 reported under U01CA264610","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"R01CA264837","project_num":null,"title":"Biomarkers of dasatinib response and resistance in T-cell acute lymphoblastic leukemia","pi_names":["David T. Teachey","Jun J. Yang"],"agency_ic":"NCI","activity_code":"R01","fiscal_years":[2021,2022,2023,2024,2025],"award_amount_usd":2961810,"org_name":"ST. JUDE CHILDREN'S RESEARCH HOSPITAL","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=R01CA264837","role":"reuse","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:43:19.296398Z","snippet":null,"locator":"PMID 39880832 reported under R01CA264837","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"P30CA021765","project_num":null,"title":"Cancer Biology (CBP)","pi_names":["Douglas R. Green","Michael A Dyer","Elizabeth Fox","GERARD PAUL ZAMBETTI","Charles G Mullighan","CHARLES ROBERTS","MOTOMI MORI","CAMENZIND G ROBINSON","Robert E Throm","Heather M Brandt","Shondra Michelle Miller","GREGORY TURNER","Youngwook Ahn","Alexandre F Carisey","Dana Jo Wallace","Gregory Armstrong","SUZANNE J. BAKER","Lindsey Munn","Gang Wu","Markos Leggas","Richard John Heath","Carlos Rodriguez-Galindo","Steven Joseph Burden","Giles W Robinson","MARTINE F. ROUSSEL (SHERR)","CHARALAMPOS KALODIMOS","Jinghui Zhang","Marcus Valentine","CLINTON F STEWART","Walter John Akers","Hartmut Berns","RICHARD A ASHMUN","Tangie Thomas","MARY V RELLING","VICTORIA CENTONZE FROHLICH","LESLIE L ROBISON","DEO KUMAR S. SRIVASTAVA","Victor M Santana","Richard James Gilbertson","RICHARD J RAHIJA","JILL M LAHTI","GERARD C GROSVELD","Charles O Rock","Sharon Lee Frase","Cynthia Wetmore","Sharyn D Baker","Amy Dovelle","CLAYTON W. NAEVE","Amy Doville","John Trainor Gray","JAMES Milford BOYETT","WILLIAM E EVANS","Kuruganti Munti","Michael B Kastan","Mona Jean Arreola","ARTHUR W. NIENHUIS","A. THOMAS LOOK","CLAYTON W NAEVE","Richard J Bram","JERRY LUTHER","KURUGANTI G MURTI","FRED BEHM","Jerold E. Rehg","RICHARD ASHMUN","CHERYL JACOBS","DEBBIE RICHARDSON","BOBBIE FISHER","BARBARA WARREN","BOBBY G WILLIAMS","FRANK WATTS","DENNIS W METZGER","EDWIN C. DOUGLAS","STEPHEN L. GEORGE","WILLIAM E. EVANS","VICTOR A. FRIED","MARY EDITH WALKER","JOSEPH SIMONE","JESSE J. JENKINS","ALLAN GRANOFF","JOSEPH V. SIMONE"],"agency_ic":"NCI","activity_code":"P30","fiscal_years":[1985,1986,1987,1988,1989,1990,1991,1992,1993,1994,1995,1996,1997,1998,1999,2000,2001,2002,2003,2004,2005,2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018,2019,2020,2021,2022,2023,2024,2025,2026],"award_amount_usd":336204292,"org_name":"ST. JUDE CHILDREN'S RESEARCH HOSPITAL","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=P30CA021765","role":"infrastructure","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:43:19.296398Z","snippet":null,"locator":"PMID 39880832 reported under P30CA021765","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"U10CA180899","project_num":null,"title":"Children's Oncology Group Statistics and Data Center","pi_names":["TODD A ALONZO","Meenakshi Devidas"],"agency_ic":"NCI","activity_code":"U10","fiscal_years":[2014,2015,2016,2017,2018,2019,2020,2021,2022,2023,2024,2025,2026],"award_amount_usd":175063337,"org_name":"UNIVERSITY OF SOUTHERN CALIFORNIA","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U10CA180899","role":"infrastructure","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:43:19.296398Z","snippet":null,"locator":"PMID 41587071 reported under U10CA180899","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"U10CA180886","project_num":null,"title":"COG NCTN Network Group Operations Center","pi_names":["Douglas S. Hawkins","Richard Aplenc","PETER C. ADAMSON","SUSAN M. BLANEY"],"agency_ic":"NCI","activity_code":"U10","fiscal_years":[2014,2015,2016,2017,2018,2019,2020,2021,2022,2023,2024,2025,2026],"award_amount_usd":455355903,"org_name":"COG RESEARCH FOUNDATION, LLC","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U10CA180886","role":"infrastructure","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:43:19.296398Z","snippet":null,"locator":"PMID 41587071 reported under U10CA180886","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"R01CA273326","project_num":null,"title":"Tracking Therapy-Resistant Alterations in Childhood Acute Lymphoblastic Leukemia","pi_names":["Xiaotu Ma"],"agency_ic":"NCI","activity_code":"R01","fiscal_years":[2022,2023,2024,2025,2026],"award_amount_usd":2088264,"org_name":"ST. JUDE CHILDREN'S RESEARCH HOSPITAL","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=R01CA273326","role":"reuse","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-20T17:43:19.296398Z","snippet":null,"locator":"PMID 41587071 reported under R01CA273326","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]}],"access_steps":[{"order":1,"action":"Confirm which trial protocols the cohort draws from","detail":"The regimen field contains protocol arm names. Reading the corresponding COG protocol publications is what turns those strings into an interpretable treatment variable.","url":null,"requires":[],"est_time":"2-3 hours","cli_snippet":null,"audience":"human","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908261Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"order":2,"action":"Scope with the 7,459 open-access files","detail":null,"url":"https://portal.gdc.cancer.gov/projects/MP2PRT-ALL","requires":[],"est_time":"1-2 hours","cli_snippet":null,"audience":"human","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908261Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"order":3,"action":"Submit a dbGaP data access request","detail":null,"url":"https://gdc.cancer.gov/access-data/obtaining-access-controlled-data","requires":["eRA Commons account","institutional signing official approval"],"est_time":"days to a few weeks","cli_snippet":null,"audience":"human","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.908261Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"order":4,"action":"Query the project from code, with no credentials","detail":"The file index is public even where files are not, so an agent can size the cohort before anyone requests access.","url":"https://docs.gdc.cancer.gov/API/Users_Guide/Getting_Started/","requires":[],"est_time":null,"cli_snippet":"curl -s 'https://api.gdc.cancer.gov/files' --get \\\n  --data-urlencode 'filters={\"op\":\"in\",\"content\":{\"field\":\"cases.project.project_id\",\"value\":[\"MP2PRT-ALL\"]}}' \\\n  --data-urlencode 'fields=file_id,file_name,data_type' \\\n  --data-urlencode 'size=10000' --data-urlencode 'format=TSV'","audience":"agent","evidence":[{"method":"derived","source_url":"https://docs.gdc.cancer.gov/API/Users_Guide/Getting_Started/","source_label":"GDC access documentation","retrieved_at":"2026-09-21T12:30:59.428573Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]},{"order":5,"action":"Pass the token when the agent needs controlled files","detail":"Without a token, an API query may return only the open subset. Compare returned counts with the record before treating them as the whole cohort.","url":"https://docs.gdc.cancer.gov/API/Users_Guide/Getting_Started/","requires":["GDC authentication token"],"est_time":null,"cli_snippet":"curl -H \"X-Auth-Token: $GDC_TOKEN\" https://api.gdc.cancer.gov/data/<file_id>","audience":"agent","evidence":[{"method":"derived","source_url":"https://docs.gdc.cancer.gov/API/Users_Guide/Getting_Started/","source_label":"GDC access documentation","retrieved_at":"2026-09-21T12:30:59.428576Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]}],"analysis_examples":[{"level":"beginner","title":"Audit whether this dataset can answer your question","question":"Which classes of analysis do this cohort's clinical records actually support, and which are ruled out before I request access?","problem":"A portal can list a field even when every value is an unusable non-answer.","lesson":"Decide whether the analysis is possible before requesting data or writing a protocol.","figure":"Horizontal bars for each probed clinical field, showing the share of cases the field is populated for against the smaller share that carries an informative value, with one-to-many fields marked as not derivable per case.","featured":true,"inputs":["A GDC project identifier","Network access to api.gdc.cancer.gov"],"outputs":["Per-field coverage table separating populated from informative values","Assay coverage as a percentage of the cohort","A yes/no verdict for six common analysis classes","A chart contrasting populated with informative coverage, field by field"],"steps":["Fetch project summary and per-assay case counts","Request facet counts for the clinical fields that gate common analyses","Separate absent fields from fields populated with non-answers","Flag one-to-many fields where per-case percentages cannot be inferred","Retrieve case-level fields and test whether a survival endpoint is derivable","Print a verdict for each analysis class"],"findings":["Four of the six analysis classes pass for CGCI-HTMCP-CC; stage-adjusted modelling and progression-free endpoints are blocked.","Vital status is informative for all 212 cases with 116 deaths, so an overall-survival endpoint is derivable.","Both stage fields and the progression field are informative for 0% of cases, which no case count can fix.","Four fields hold several records per case, so their per-case share cannot be inferred from a facet count at all."],"contributor":null,"contributor_url":null,"language":"python","est_runtime":"about a minute","est_compute":null,"workbook_path":"workbooks/python/01_can_i_answer_this.py","workbook_url":null,"notebook_download_url":"/data/notebooks/01_can_i_answer_this.ipynb","notebook_preview_url":"/data/notebooks/01_can_i_answer_this.png","notebook_preview_width":1021,"notebook_preview_height":813,"colab_url":null,"binder_url":null,"receipt":{"executed":true,"executed_at":"2026-09-21T00:40:59.561676Z","runtime_seconds":6.57,"executor":"nbclient / python 3.12.13 / Darwin 25.5.0 arm64","package_versions":{"python":"3.12.13","pandas":"3.0.6","numpy":"2.5.3","matplotlib":"3.11.2","lifelines":"0.30.0","scipy":"1.18.1","requests":"2.34.2","httpx":"0.28.1"},"n_cells":7,"n_cells_executed":7,"output_hash":"dc14b4c93e7e9d6aff322ff2d0de47b8","data_retrieved_at":null,"error":null},"template_source":"01_can_i_answer_this","evidence":[{"method":"curated","source_url":null,"source_label":"CD2S workbook","retrieved_at":"2026-09-21T12:30:59.450286Z","snippet":null,"locator":"workbooks/python/01_can_i_answer_this.py","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Executed end to end against the live public APIs; the receipt records when, with which package versions and how long it took."}]},{"level":"advanced","title":"Select a dataset the way an agent should","question":"Given a research goal, which dataset should an agent choose, and what must it refuse to do with it?","problem":"Ranking by size or fame can select a large dataset that cannot answer the question.","lesson":"Filter on measured capability, rank on fit, and carry blocking limitations into the analysis brief.","figure":"Horizontal bars of the fit score for each shortlisted dataset, with the selected cohort highlighted, showing whether the ranking is decided by overall fit or by one dominant term.","featured":false,"inputs":["The CD2S structured export","pandas"],"outputs":["Contrast between a size-ranked and a capability-ranked selection","A transparent fit score favoring under-used resources","Blocking limitations read before committing","A machine-readable task brief for the next step","A chart of the ranked fit scores with the selected cohort highlighted"],"steps":["Load the structured index","Show what a naive size-ranked selection returns","Filter on measured capability rather than description","Rank on fit, rewarding under-used datasets","Read blocking limitations from the full record","Emit a task brief including what the agent must not do"],"findings":["A size-ranked agent picks msk_ch_2023 and its 42,714 cases, which record neither treatment response nor a survival endpoint.","Only 51 of 602 datasets record both, measured from field coverage rather than description.","Ranking on fit selects MP2PRT-ALL - 1,510 cases, 100 months of follow-up - and carries its 4 major limitations into the brief."],"contributor":null,"contributor_url":null,"language":"python","est_runtime":"under a minute","est_compute":null,"workbook_path":"workbooks/python/06_agent_dataset_selection.py","workbook_url":null,"notebook_download_url":"/data/notebooks/06_agent_dataset_selection.ipynb","notebook_preview_url":"/data/notebooks/06_agent_dataset_selection.png","notebook_preview_width":1021,"notebook_preview_height":685,"colab_url":null,"binder_url":null,"receipt":{"executed":true,"executed_at":"2026-09-21T00:43:02.488936Z","runtime_seconds":1.19,"executor":"nbclient / python 3.12.13 / Darwin 25.5.0 arm64","package_versions":{"python":"3.12.13","pandas":"3.0.6","numpy":"2.5.3","matplotlib":"3.11.2","lifelines":"0.30.0","scipy":"1.18.1","requests":"2.34.2","httpx":"0.28.1"},"n_cells":8,"n_cells_executed":8,"output_hash":"dc49bfd688a5ab7ef77292e914fdd645","data_retrieved_at":null,"error":null},"template_source":"06_agent_dataset_selection","evidence":[{"method":"curated","source_url":null,"source_label":"CD2S workbook","retrieved_at":"2026-09-21T12:30:59.450374Z","snippet":null,"locator":"workbooks/python/06_agent_dataset_selection.py","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Executed end to end against the live public APIs; the receipt records when, with which package versions and how long it took."}]}],"agent_package":{"json_url":"/data/datasets/gdc-mp2prt-all.json","jsonld_url":"/data/jsonld/gdc-mp2prt-all.jsonld","croissant_url":"/data/croissant/gdc-mp2prt-all.json","instructions_url":"/data/agent/gdc-mp2prt-all.md","bundle_url":null,"mcp_resource_uri":null},"related_dataset_ids":[],"related_underexplored_ids":[],"review":{"status":"project_curated","reviewer":"CD2S project curation","reviewer_affiliation":null,"reviewed_at":"2026-09-18","sections_reviewed":["useful_for","limitations","inappropriate_uses","access_steps"],"open_questions":["The machine-inferred primary publication for this cohort is not authoritative. The cohort derives from Children's Oncology Group trials; confirm the correct marker publication with the COG data team before citing one."],"notes":null},"verification":{"last_verified_at":null,"link_checks":[],"n_links_ok":0,"n_links_broken":0,"upstream_version_seen":null,"upstream_version_changed":false,"upstream_counts_seen":{},"upstream_drift":{},"notes":[]},"is_showcase":true,"completeness_score":92.9,"tags":["gdc","longitudinal","mp2prt","paediatric","released","treatment-response","trial-linked","underexplored-candidate"],"search_text":null}