{"id":"gdc-fm-ad","title":"Foundation Medicine Adult Cancer Clinical Dataset (FM-AD)","short_title":"FM-AD","aliases":["FM-AD"],"summary":"The Foundation Medicine Adult Cancer Clinical Dataset is the largest single cohort in the Genomic Data Commons: 18,004 patients across many tumor types, profiled with a targeted DNA panel in a clinical rather than research setting. That scale is genuinely useful for questions about mutation frequency and co-occurrence in a real-world population, which is precisely where research cohorts are least representative.\nIt is also the clearest case in this corpus of a dataset whose catalog entry invites analyses it cannot support. Vital status is populated for 100% of cases and informative for 0% - every value is \"not reported\". Race is \"not reported\" for all 18,004 patients. Every treatment field is empty. Progression and last known disease status are populated for every case and informative for none. A researcher attracted by the sample size will find, after obtaining controlled access to 54,012 files, that no outcome-anchored analysis is possible.","one_liner":"18,004 patients profiled with a targeted clinical panel - the largest cohort in the Genomic Data Commons, with no informative vital status, no race data, and no treatment records.","identifiers":[{"scheme":"gdc_project_id","value":"FM-AD","url":"https://portal.gdc.cancer.gov/projects/FM-AD","is_primary":true,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/FM-AD?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API 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/projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]}],"repository":{"name":"NCI Genomic Data Commons","short_name":"GDC","url":"https://portal.gdc.cancer.gov","is_nci_crdc_node":true,"is_nih_repository":true},"additional_repositories":[],"program_name":"FM","program_url":"https://portal.gdc.cancer.gov/analysis_page?app=Projects","nci_program":"FM","generating_institutions":[],"data_generation_funding_role":"generation","version":null,"release_date":"2017-01-01","last_upstream_update":null,"retrieved_at":"2026-09-18T02:32:30.425616Z","landing_page_url":"https://portal.gdc.cancer.gov/projects/FM-AD","cancer_types":[{"label":"Not Reported","ontology":null,"code":null,"url":null},{"label":"Cystic, Mucinous and Serous Neoplasms","ontology":null,"code":null,"url":null},{"label":"Miscellaneous Tumors","ontology":null,"code":null,"url":null},{"label":"Germ Cell Neoplasms","ontology":null,"code":null,"url":null},{"label":"Complex Mixed and Stromal Neoplasms","ontology":null,"code":null,"url":null},{"label":"Thymic Epithelial Neoplasms","ontology":null,"code":null,"url":null},{"label":"Ductal and Lobular Neoplasms","ontology":null,"code":null,"url":null},{"label":"Adnexal and Skin Appendage Neoplasms","ontology":null,"code":null,"url":null},{"label":"Transitional Cell Papillomas and Carcinomas","ontology":null,"code":null,"url":null},{"label":"Meningiomas","ontology":null,"code":null,"url":null},{"label":"Mesothelial Neoplasms","ontology":null,"code":null,"url":null},{"label":"Mucoepidermoid Neoplasms","ontology":null,"code":null,"url":null},{"label":"Neuroepitheliomatous Neoplasms","ontology":null,"code":null,"url":null},{"label":"Acinar Cell Neoplasms","ontology":null,"code":null,"url":null},{"label":"Adenomas and Adenocarcinomas","ontology":null,"code":null,"url":null},{"label":"Gliomas","ontology":null,"code":null,"url":null},{"label":"Nevi and Melanomas","ontology":null,"code":null,"url":null},{"label":"Specialized Gonadal Neoplasms","ontology":null,"code":null,"url":null},{"label":"Squamous Cell Neoplasms","ontology":null,"code":null,"url":null},{"label":"Complex Epithelial Neoplasms","ontology":null,"code":null,"url":null},{"label":"Paragangliomas and Glomus Tumors","ontology":null,"code":null,"url":null},{"label":"Epithelial Neoplasms, NOS","ontology":null,"code":null,"url":null},{"label":"Basal Cell Neoplasms","ontology":null,"code":null,"url":null}],"primary_sites":["Not Reported","Esophagus","Other endocrine glands and related structures","Stomach","Skin","Unknown","Bladder","Nasopharynx","Vulva","Other and unspecified major salivary glands","Breast","Testis","Pancreas","Trachea","Penis","Retroperitoneum and peritoneum","Rectum","Ureter","Vagina","Other and unspecified female genital organs","Colon","Adrenal gland","Liver and intrahepatic bile ducts","Other and ill-defined sites","Prostate gland","Other and ill-defined digestive organs","Spinal cord, cranial nerves, and other parts of central nervous system","Anus and anal canal","Small intestine","Peripheral nerves and autonomic nervous system","Other and unspecified urinary organs","Thyroid gland","Ovary","Thymus","Cervix uteri","Bronchus and lung","Other and unspecified parts of biliary tract","Heart, mediastinum, and pleura","Uterus, NOS","Kidney","Gallbladder","Eye and adnexa"],"subject":{"scope":"pan_cancer","tissues":[],"evidence":[{"method":"derived","source_url":null,"source_label":"cds.subjects","retrieved_at":null,"snippet":null,"locator":"cancer_types: Not Reported, Cystic, Mucinous and Serous Neoplasms, Miscellaneous Tumors, Germ Cell Neoplasms, Complex Mixed and Stromal Neoplasms, Thymic Epithelial Neoplasms, Ductal and Lobular Neoplasms, Adnexal and Skin Appendage Neoplasms, Transitional Cell Papillomas and Carcinomas, Meningiomas, Mesothelial Neoplasms, Mucoepidermoid Neoplasms, Neuroepitheliomatous Neoplasms, Acinar Cell Neoplasms, Adenomas and Adenocarcinomas, Gliomas, Nevi and Melanomas, Specialized Gonadal Neoplasms, Squamous Cell Neoplasms, Complex Epithelial Neoplasms, Paragangliomas and Glomus Tumors, Epithelial Neoplasms, NOS, Basal Cell Neoplasms; primary_sites: Not Reported, Esophagus, Other endocrine glands and related structures, Stomach, Skin, Unknown, Bladder, Nasopharynx, Vulva, Other and unspecified major salivary glands, Breast, Testis, Pancreas, Trachea, Penis, Retroperitoneum and peritoneum, Rectum, Ureter, Vagina, Other and unspecified female genital organs, Colon, Adrenal gland, Liver and intrahepatic bile ducts, Other and ill-defined sites, Prostate gland, Other and ill-defined digestive organs, Spinal cord, cranial nerves, and other parts of central nervous system, Anus and anal canal, Small intestine, Peripheral nerves and autonomic nervous system, Other and unspecified urinary organs, Thyroid gland, Ovary, Thymus, Cervix uteri, Bronchus and lung, Other and unspecified parts of biliary tract, Heart, mediastinum, and pleura, Uterus, NOS, Kidney, Gallbladder, Eye and adnexa","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Four or more repository-stated tissues make this pan-cancer."}]},"is_pediatric":null,"model_systems":[],"cohort":{"n_cases":18004,"n_samples":null,"n_aliquots":null,"n_files":54096,"total_bytes":301802073,"n_tumor_cases":null,"n_normal_cases":null,"has_matched_normal":null,"demographics":{"sex":{"female":10197,"male":7798,"unknown":9},"race":{"not reported":18004},"ethnicity":{"not reported":18004},"age_at_diagnosis_years":{"n":12000.0,"min":19.0,"q1":50.2,"median":59.1,"q3":67.3,"max":89.0},"vital_status":{"not 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