{"id":"gdc-cgci-htmcp-lc","title":"HIV+ Tumor Molecular Characterization Project - Lung Cancer","short_title":"CGCI-HTMCP-LC","aliases":["cgci_htmcp_lc"],"summary":"People living with HIV have substantially elevated lung cancer incidence and worse outcomes, and are close to absent from the cohorts that define lung cancer genomics. This is the smallest cohort we have made a showcase page for, and we included it because size is not the only thing that determines whether a dataset is worth knowing about.\nAll 39 cases carry whole genome sequencing, 38 RNA sequencing and 37 microRNA. 26 patients are recorded as Black or African American. Pathologic stage is recorded for 62% and prior treatment for 92%, both unusually good for a cohort of this size.","one_liner":"39 lung cancers from an HIV-enriched cohort, two thirds Black or African American, with whole genome sequencing on every case and clinical staging on 62% - very small, and addressing a population that appears in almost no lung cancer genomics.","identifiers":[{"scheme":"gdc_project_id","value":"CGCI-HTMCP-LC","url":"https://portal.gdc.cancer.gov/projects/CGCI-HTMCP-LC","is_primary":true,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/CGCI-HTMCP-LC?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"gdc_program","value":"CGCI","url":null,"is_primary":false,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/CGCI-HTMCP-LC?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"dbgap_phs","value":"phs000530","url":"https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000530","is_primary":false,"evidence":[{"method":"api","source_url":"https://api.gdc.cancer.gov/projects/CGCI-HTMCP-LC?expand=summary,summary.data_categories,summary.experimental_strategies,program","source_label":"GDC API /projects","retrieved_at":"2026-09-18T02:32:25.909822Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"idc_collection_id","value":"cgci_htmcp_lc","url":"https://portal.imaging.datacommons.cancer.gov/explore/?collection_id=cgci_htmcp_lc","is_primary":true,"evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/cgci_htmcp_lc","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"tcia_collection","value":"CGCI-HTMCP-LC","url":"https://www.cancerimagingarchive.net/collections/","is_primary":false,"evidence":[{"method":"api","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/cgci_htmcp_lc","source_label":"IDC v3 API /collections","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"scheme":"zenodo","value":"10.5281/zenodo.17381428","url":null,"is_primary":false,"evidence":[{"method":"fulltext","source_url":"https://api.imaging.datacommons.cancer.gov/v3/collections/cgci_htmcp_lc","source_label":"IDC collection description","retrieved_at":"2026-09-18T02:44:36.389375Z","snippet":"from the GDC and converted to DICOM Slide Microscopy format. Please see the CGCI-HTMCP-LC Zenodo page to learn more about the images and to obtain any supporting metadata for this collection.","locator":"accession extracted from description prose","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Cross-repository link recovered from prose; verify before relying on it."}]}],"repository":{"name":"NCI Genomic Data Commons","short_name":"GDC","url":"https://portal.gdc.cancer.gov","is_nci_crdc_node":true,"is_nih_repository":true},"additional_repositories":[{"name":"NCI Imaging Data 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Not machine-generated."}]}],"inappropriate_uses":[{"statement":"Any statistically powered discovery analysis.","reason":"39 cases cannot support it.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.907874Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. 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