{"id":"gdc-cgci-htmcp-dlbcl","title":"HIV+ Tumor Molecular Characterization Project - Diffuse Large B-Cell Lymphoma","short_title":"CGCI-HTMCP-DLBCL","aliases":["cgci_htmcp_dlbcl"],"summary":"HIV-associated lymphoma is common where HIV is common and rare in the cohorts that define lymphoma genomics. This cohort addresses that gap directly: 70 cases with whole genome sequencing on 66, RNA sequencing on 55 and microRNA on 60, of which 34 patients are recorded as Black or African American and 18 as white.\nClinical annotation is better than the cohort size suggests. 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Please see the CGCI-HTMCP-DLBCL Zenodo page to learn more about the images and to obtain any supporting metadata for this collection.","locator":"accession extracted from description prose","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Cross-repository link recovered from prose; verify before relying on it."}]}],"repository":{"name":"NCI Genomic Data Commons","short_name":"GDC","url":"https://portal.gdc.cancer.gov","is_nci_crdc_node":true,"is_nih_repository":true},"additional_repositories":[{"name":"NCI Imaging Data 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Not machine-generated."}]}],"inappropriate_uses":[{"statement":"Comparing HIV-positive with HIV-negative lymphoma within the cohort.","reason":"HIV status is not a structured variable in these records.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.907807Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]},{"statement":"Genome-wide significance testing.","reason":"66 whole genomes cannot support it.","evidence":[{"method":"curated","source_url":null,"source_label":"Expert review","retrieved_at":"2026-09-21T12:30:56.907807Z","snippet":null,"locator":null,"confidence":"high","reviewer":"CD2S project curation","reviewed_at":"2026-09-18","note":"Written by a named reviewer after reading the source documentation and the measured field coverage. Not machine-generated."}]}],"primary_publications":[{"pmid":"41996576","pmcid":"PMC13089434","doi":"10.1093/bib/bbag167","title":"CRESCENT: a deep learning framework with multi-scale attention for detecting recurrent copy number alterations.","journal":"Briefings in bioinformatics","year":2026,"authors_short":"Feng et al.","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/41996576/","is_open_access":true,"citation_count":0,"evidence":[{"method":"derived","source_url":null,"source_label":"Candidate primary publication (machine-inferred)","retrieved_at":"2026-09-20T18:16:46.769072Z","snippet":null,"locator":"earliest highly cited article analyzing CGCI-HTMCP-DLBCL (published 2026)","confidence":"low","reviewer":null,"reviewed_at":null,"note":"Inferred, not authoritative. The source repository does not publish a marker-paper link for this dataset, so we nominate the earliest heavily cited article that analyzed it. 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Every dataset is measured with the same single section field per tier, so the counts are comparable; the per-tier value is the largest across the dataset's own accessions, excluding any accession shared with other datasets in the corpus. No article was found under this accession, so there is no count to correct and no sample was drawn."},{"method":"derived","source_url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search","source_label":"Europe PMC first-reference dating","retrieved_at":"2026-09-20T18:16:46.769072Z","snippet":null,"locator":"first referenced in 2025 (METHODS section)","confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Availability dated from the literature (epmc-first-reference-v2) rather than from repository file timestamps, which record re-harmonization. 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