{"id":"cbio-aml-ohsu-2022","title":"Acute Myeloid Leukemia (OHSU, Cancer Cell 2022)","short_title":"aml_ohsu_2022","aliases":["aml_ohsu_2022"],"summary":"Whole-exome and transcriptomic sequencing of 942 acute myeloid leukemia samples (with 500 matched normals) from the Beat AML program.","one_liner":null,"identifiers":[{"scheme":"cbioportal_study_id","value":"aml_ohsu_2022","url":"https://www.cbioportal.org/study/summary?id=aml_ohsu_2022","is_primary":true,"evidence":[{"method":"api","source_url":"https://www.cbioportal.org/api/studies/aml_ohsu_2022","source_label":"cBioPortal API /studies","retrieved_at":"2026-09-18T02:48:40.878054Z","snippet":null,"locator":null,"confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]}],"repository":{"name":"cBioPortal for Cancer Genomics","short_name":"cBioPortal","url":"https://www.cbioportal.org","is_nci_crdc_node":false,"is_nih_repository":false},"additional_repositories":[],"program_name":"Investigator-initiated cohort (harmonized in cBioPortal)","program_url":"https://www.cbioportal.org/study/summary?id=aml_ohsu_2022","nci_program":null,"generating_institutions":[],"data_generation_funding_role":"generation","version":null,"release_date":null,"last_upstream_update":null,"retrieved_at":"2026-09-18T02:48:40.878054Z","landing_page_url":"https://www.cbioportal.org/study/summary?id=aml_ohsu_2022","cancer_types":[{"label":"Acute Myeloid Leukemia","ontology":"cBioPortal","code":"aml","url":null}],"primary_sites":["mnm"],"subject":{"scope":"single","tissues":["MYELOID"],"evidence":[{"method":"derived","source_url":null,"source_label":"cds.subjects","retrieved_at":null,"snippet":null,"locator":"cancer_types: Acute Myeloid Leukemia; primary_sites: mnm","confidence":"high","reviewer":null,"reviewed_at":null,"note":"OncoTree code rolled up to its pinned tissue."}]},"is_pediatric":null,"model_systems":[],"cohort":{"n_cases":805,"n_samples":942,"n_aliquots":null,"n_files":null,"total_bytes":null,"n_tumor_cases":null,"n_normal_cases":null,"has_matched_normal":null,"demographics":{"sex":{"Male":449,"Female":355},"race":{"White":479,"Unknown":25,"Multiracial":9,"Pacific Islander":3,"Declined":5,"Black":23,"American Indian":1,"Asian":15},"ethnicity":{"HISPANIC":39,"NON-HISPANIC":402,"UNKNOWN":13,"DECLINED":2},"age_at_diagnosis_years":{},"vital_status":{"DECEASED":468,"LIVING":305},"country_or_region":{},"evidence":[{"method":"api","source_url":"https://www.cbioportal.org/api/studies/aml_ohsu_2022","source_label":"cBioPortal API /studies","retrieved_at":"2026-09-19T03:24:22.638351Z","snippet":null,"locator":"POST /clinical-data-counts/fetch","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"evidence":[{"method":"api","source_url":"https://www.cbioportal.org/api/studies/aml_ohsu_2022","source_label":"cBioPortal API /studies","retrieved_at":"2026-09-18T02:48:40.878054Z","snippet":null,"locator":"field: allSampleCount","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"assays":[{"modality":"targeted_dna","label":"Mutation calls (panel, exome or genome)","platform":null,"n_cases":null,"n_samples":903,"n_files":null,"data_levels":["processed matrix"],"access_tier":"open","evidence":[{"method":"api","source_url":"https://www.cbioportal.org/api/studies/aml_ohsu_2022","source_label":"cBioPortal API /studies","retrieved_at":"2026-09-18T02:48:40.878054Z","snippet":null,"locator":"field: sequencedSampleCount","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"rna_seq","label":"RNA sequencing expression","platform":null,"n_cases":null,"n_samples":698,"n_files":null,"data_levels":["processed matrix"],"access_tier":"open","evidence":[{"method":"api","source_url":"https://www.cbioportal.org/api/studies/aml_ohsu_2022","source_label":"cBioPortal API /studies","retrieved_at":"2026-09-18T02:48:40.878054Z","snippet":null,"locator":"field: mrnaRnaSeqSampleCount","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"modality":"structural_variant","label":"Structural variants / fusions","platform":null,"n_cases":null,"n_samples":null,"n_files":168,"data_levels":[],"access_tier":"open","evidence":[{"method":"api","source_url":"https://www.cbioportal.org/api/studies/aml_ohsu_2022","source_label":"cBioPortal API /studies","retrieved_at":"2026-09-18T02:48:40.878054Z","snippet":null,"locator":"field: structuralVariantCount","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]}],"clinical_variables":[{"name":"cbioportal:CAUSE_OF_DEATH","harmonized_name":"demographic.cause_of_death","label":"Cause Of Death","category":"outcome","n_nonmissing":773,"n_not_reported":0,"n_informative":773,"n_total":805,"coverage_pct":96.0,"populated_pct":96.0,"is_repeated":false,"example_values":["Dead-Disease","Alive","Dead-Unknown","Dead-Treatment","Dead-Other"],"unit":"patients","evidence":[{"method":"api","source_url":"https://www.cbioportal.org/api/studies/aml_ohsu_2022","source_label":"cBioPortal API /studies","retrieved_at":"2026-09-19T03:24:22.203795Z","snippet":null,"locator":"POST /clinical-data-counts/fetch, attribute CAUSE_OF_DEATH; denominator is 805 patients","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"cbioportal:ETHNICITY","harmonized_name":"demographic.ethnicity","label":"Ethnicity Category","category":"demographic","n_nonmissing":456,"n_not_reported":15,"n_informative":441,"n_total":805,"coverage_pct":54.8,"populated_pct":56.6,"is_repeated":false,"example_values":["NON-HISPANIC","HISPANIC","UNKNOWN","DECLINED"],"unit":"patients","evidence":[{"method":"api","source_url":"https://www.cbioportal.org/api/studies/aml_ohsu_2022","source_label":"cBioPortal API /studies","retrieved_at":"2026-09-19T03:24:22.203795Z","snippet":null,"locator":"POST /clinical-data-counts/fetch, attribute ETHNICITY; denominator is 805 patients","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"cbioportal:ONCOTREE_CODE","harmonized_name":"diagnoses.primary_diagnosis","label":"Oncotree Code","category":"diagnosis","n_nonmissing":942,"n_not_reported":0,"n_informative":942,"n_total":942,"coverage_pct":100.0,"populated_pct":100.0,"is_repeated":false,"example_values":["AML","MDS","ALAL","MDS/MPN","MPN","MBN"],"unit":"samples","evidence":[{"method":"api","source_url":"https://www.cbioportal.org/api/studies/aml_ohsu_2022","source_label":"cBioPortal API /studies","retrieved_at":"2026-09-19T03:24:22.203795Z","snippet":null,"locator":"POST /clinical-data-counts/fetch, attribute ONCOTREE_CODE; denominator is 942 samples","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"cbioportal:OS_STATUS","harmonized_name":"demographic.vital_status","label":"Overall Survival Status","category":"outcome","n_nonmissing":773,"n_not_reported":0,"n_informative":773,"n_total":805,"coverage_pct":96.0,"populated_pct":96.0,"is_repeated":false,"example_values":["DECEASED","LIVING"],"unit":"patients","evidence":[{"method":"api","source_url":"https://www.cbioportal.org/api/studies/aml_ohsu_2022","source_label":"cBioPortal API /studies","retrieved_at":"2026-09-19T03:24:22.203795Z","snippet":null,"locator":"POST /clinical-data-counts/fetch, attribute OS_STATUS; denominator is 805 patients","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"cbioportal:RACE","harmonized_name":"demographic.race","label":"Race Category","category":"demographic","n_nonmissing":560,"n_not_reported":30,"n_informative":530,"n_total":805,"coverage_pct":65.8,"populated_pct":69.6,"is_repeated":false,"example_values":["White","Unknown","Black","Asian","Multiracial","Declined"],"unit":"patients","evidence":[{"method":"api","source_url":"https://www.cbioportal.org/api/studies/aml_ohsu_2022","source_label":"cBioPortal API /studies","retrieved_at":"2026-09-19T03:24:22.203795Z","snippet":null,"locator":"POST /clinical-data-counts/fetch, attribute RACE; denominator is 805 patients","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"cbioportal:SEX","harmonized_name":"demographic.sex_at_birth","label":"Sex","category":"demographic","n_nonmissing":804,"n_not_reported":0,"n_informative":804,"n_total":805,"coverage_pct":99.9,"populated_pct":99.9,"is_repeated":false,"example_values":["Male","Female"],"unit":"patients","evidence":[{"method":"api","source_url":"https://www.cbioportal.org/api/studies/aml_ohsu_2022","source_label":"cBioPortal API /studies","retrieved_at":"2026-09-19T03:24:22.203795Z","snippet":null,"locator":"POST /clinical-data-counts/fetch, attribute SEX; denominator is 805 patients","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},{"name":"cbioportal:OS_MONTHS","harmonized_name":"diagnoses.days_to_last_follow_up","label":"Overall Survival (Months)","category":"followup","n_nonmissing":805,"n_not_reported":null,"n_informative":null,"n_total":805,"coverage_pct":null,"populated_pct":100.0,"is_repeated":false,"example_values":[],"unit":"months","evidence":[{"method":"api","source_url":"https://www.cbioportal.org/api/studies/aml_ohsu_2022","source_label":"cBioPortal API /studies","retrieved_at":"2026-09-19T03:24:22.425083Z","snippet":null,"locator":"GET /studies/aml_ohsu_2022/clinical-data?attributeId=OS_MONTHS; 805 of 805 patients carry a value","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]}],"longitudinal":{"has_followup":true,"has_survival_endpoint":true,"survival_endpoints":["overall survival"],"median_followup_months":11.0,"max_followup_months":177.4,"n_cases_with_followup":805,"has_serial_samples":null,"timepoints":[],"n_cases_with_serial":null,"has_treatment_response":false,"response_criteria":[],"evidence":[{"method":"api","source_url":"https://www.cbioportal.org/api/studies/aml_ohsu_2022","source_label":"cBioPortal API /studies","retrieved_at":"2026-09-19T03:24:22.638351Z","snippet":null,"locator":"derived from OS_MONTHS; 468 deaths recorded","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]},"access":{"tier":"open","open_components":["harmonized mutation, copy-number, expression and clinical files"],"controlled_components":[],"mechanism":"Processed data download from the cBioPortal study page or its public REST API; no account required. Primary raw data remain wherever the original investigators deposited them.","dua_url":null,"data_access_committee":null,"typical_turnaround":null,"embargo_until":null,"login_required":false,"citation_requirement":"Cite the original publication, and cite cBioPortal if the portal's harmonized files were used.","license":"Per-study terms; cBioPortal asks that the original study be cited","publication_policy_url":"https://www.cbioportal.org/faq","evidence":[{"method":"api","source_url":"https://www.cbioportal.org/api/studies/aml_ohsu_2022","source_label":"cBioPortal API /studies","retrieved_at":"2026-09-18T02:48:40.878054Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":null}]},"useful_for":[],"limitations":[],"inappropriate_uses":[],"primary_publications":[{"pmid":"35868306","pmcid":null,"doi":null,"title":null,"journal":null,"year":null,"authors_short":"Bottomly et al. Cancer Cell 2022","n_authors":null,"url":"https://pubmed.ncbi.nlm.nih.gov/35868306/","is_open_access":null,"citation_count":null,"evidence":[{"method":"api","source_url":"https://www.cbioportal.org/api/studies/aml_ohsu_2022","source_label":"cBioPortal API /studies","retrieved_at":"2026-09-18T02:48:40.878054Z","snippet":null,"locator":"field: pmid","confidence":"high","reviewer":null,"reviewed_at":null,"note":null}]}],"reuse":[],"reuse_metrics":{"n_candidates_screened":0,"n_by_tier":{},"n_by_tier_raw":{},"accession_precision":null,"n_citations_to_primary_publication":361,"citation_to_reuse_ratio":null,"has_citable_accession":false,"n_verified_reuse":null,"n_reuse_examined":0,"n_independent_reuse":0,"n_nci_funded_reuse":0,"first_reuse_year":null,"latest_reuse_year":null,"years_since_release":null,"expected_reuse":null,"reuse_gap_index":null,"reuse_gap_percentile":null,"search_strategy_id":"epmc-index-v3","searched_at":"2026-09-20T18:07:30.933910Z","no_reuse_identified":false,"evidence":[{"method":"derived","source_url":null,"source_label":"reuse index","retrieved_at":"2026-09-20T18:07:30.933910Z","snippet":null,"locator":null,"confidence":"low","reviewer":null,"reviewed_at":null,"note":"This dataset has no accession specific enough to search for in the literature, so citation-based reuse cannot be measured. Absence of a count here is not evidence of absence of reuse."}]},"underexplored":{"is_underexplored":false,"basis":["Not assessed: this dataset has no accession specific enough for citation-based reuse tracing, so a shortfall cannot be measured."],"index_value":null,"percentile":null,"comparator_set":"rgi-huber-v2","evidence":[]},"grants":[{"core_project_num":"U54CA224019","project_num":null,"title":"Architecture and Trajectory of Acquired Resistance to Therapy in AML","pi_names":["BRIAN J DRUKER","Shannon K. McWeeney","Jeffrey Wallace Tyner","Anupriya Agarwal","Tothu Q Vu"],"agency_ic":"NCI","activity_code":"U54","fiscal_years":[2017,2019,2020,2021,2022,2023,2024,2025,2026],"award_amount_usd":24957380,"org_name":"OREGON HEALTH & SCIENCE UNIVERSITY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U54CA224019","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-18T02:48:44.992046Z","snippet":null,"locator":"PMID 35868306 reported under U54CA224019","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"U01CA271412","project_num":null,"title":"Proteogenomic characterization of early and late resistance mechanisms in acute myeloid leukemia","pi_names":["BRIAN J DRUKER","Paul D Piehowski","Jeffrey Wallace Tyner"],"agency_ic":"NCI","activity_code":"U01","fiscal_years":[2022,2023,2024,2025,2026],"award_amount_usd":5771926,"org_name":"OREGON HEALTH & SCIENCE UNIVERSITY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U01CA271412","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-18T02:48:44.992046Z","snippet":null,"locator":"PMID 35868306 reported under U01CA271412","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"U01CA217862","project_num":null,"title":"Functional Genomic Discovery of Pathway Targeted and Immune Modulatory Therapeutic Combinations in Hematologic Malignancies","pi_names":["BRIAN J DRUKER","Jeffrey Wallace Tyner","Adam Arne Margolin"],"agency_ic":"NCI","activity_code":"U01","fiscal_years":[2017,2018,2019,2020,2021],"award_amount_usd":5255746,"org_name":"OREGON HEALTH & SCIENCE UNIVERSITY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U01CA217862","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-18T02:48:44.992046Z","snippet":null,"locator":"PMID 35868306 reported under U01CA217862","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"U01CA214116","project_num":null,"title":"Proteogenomic Translational Research Center for Clinical Proteomic","pi_names":["BRIAN J DRUKER","Karin D Rodland"],"agency_ic":"NCI","activity_code":"U01","fiscal_years":[2017,2018,2019,2020,2021],"award_amount_usd":6816883,"org_name":"BATTELLE PACIFIC NORTHWEST LABORATORIES","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=U01CA214116","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-18T02:48:44.992046Z","snippet":null,"locator":"PMID 35868306 reported under U01CA214116","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"R01CA262758","project_num":null,"title":"Mechanisms of venetoclax combination activity in acute myeloid leukemia","pi_names":["Stephen E Kurtz","Jeffrey Wallace Tyner"],"agency_ic":"NCI","activity_code":"R01","fiscal_years":[2021,2022,2023,2024,2025,2026],"award_amount_usd":2122204,"org_name":"OREGON HEALTH & SCIENCE UNIVERSITY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=R01CA262758","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-18T02:48:44.992046Z","snippet":null,"locator":"PMID 35868306 reported under R01CA262758","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"R01CA247943","project_num":null,"title":"Mechanisms of differentiation blockade in CSF3R-mutant AML","pi_names":["Julia E Maxson"],"agency_ic":"NCI","activity_code":"R01","fiscal_years":[2021,2022,2023,2024,2025],"award_amount_usd":2023612,"org_name":"OREGON HEALTH & SCIENCE UNIVERSITY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=R01CA247943","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-18T02:48:44.992046Z","snippet":null,"locator":"PMID 35868306 reported under R01CA247943","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"R01CA245002","project_num":null,"title":"Targeting PTPN11 dependent Hematologic Malignancies","pi_names":["BILL H CHANG","Jeffrey Wallace Tyner"],"agency_ic":"NCI","activity_code":"R01","fiscal_years":[2020,2021,2022,2023,2024],"award_amount_usd":1729672,"org_name":"OREGON HEALTH & SCIENCE UNIVERSITY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=R01CA245002","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-18T02:48:44.992046Z","snippet":null,"locator":"PMID 35868306 reported under R01CA245002","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"R01CA229875","project_num":null,"title":"Mechanisms and targeting of inflammatory cytokine-driven expansion and progression in AML","pi_names":["Anupriya Agarwal"],"agency_ic":"NCI","activity_code":"R01","fiscal_years":[2019,2020,2021,2022,2023],"award_amount_usd":1573681,"org_name":"OREGON HEALTH & SCIENCE UNIVERSITY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=R01CA229875","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-18T02:48:44.992046Z","snippet":null,"locator":"PMID 35868306 reported under R01CA229875","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"R01CA214428","project_num":null,"title":"An Academic-Industry Partnership to Advance Functional Genomics for Personalized Oncology.","pi_names":["CHRISTOPHER J KEMP"],"agency_ic":"NCI","activity_code":"R01","fiscal_years":[2018,2019,2020,2021,2022],"award_amount_usd":3022338,"org_name":"FRED HUTCHINSON CANCER RESEARCH CENTER","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=R01CA214428","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-18T02:48:44.992046Z","snippet":null,"locator":"PMID 35868306 reported under R01CA214428","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"R00CA237630","project_num":null,"title":"Characterizing the pathogenesis and targeted therapeutics of Wilms' Tumor 1 (WT1) mutations in AML","pi_names":["Haijiao Zhang"],"agency_ic":"NCI","activity_code":"R00","fiscal_years":[2023],"award_amount_usd":249000,"org_name":"OREGON HEALTH & SCIENCE UNIVERSITY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=R00CA237630","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-18T02:48:44.992046Z","snippet":null,"locator":"PMID 35868306 reported under R00CA237630","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"P30CA069533","project_num":null,"title":"Translational Oncology Research Program","pi_names":["Jeffrey Wallace Tyner","Mindy Roberts","SUSAN A. FLOCKE","Eneida R Nemecek","Shivaani Kummar","Luiz Eduardo Bertassoni","Grace B Gill","Laura Madeline Heiser","JACKILEN SHANNON","Michael Tworoger","LISA M COUSSENS"],"agency_ic":"NCI","activity_code":"P30","fiscal_years":[2025,2026],"award_amount_usd":8830605,"org_name":"OREGON HEALTH & SCIENCE UNIVERSITY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=P30CA069533","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-18T02:48:44.992046Z","snippet":null,"locator":"PMID 35868306 reported under P30CA069533","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"P30CA042014","project_num":null,"title":"Cancer Biostatistics (CB)","pi_names":["Yian Ann Chen","Gary Christopher Fillmore","Max Loveless","KATHARINE S ULLMAN","MARTIN MCMAHON","BRIAN DALLEY","Howard Colman","CORNELIA M ULRICH","Rachel M. Ceballos","Neeraj Agarwal","Sheri L Holmen","Whitney F Maxwell","NICOLA J. CAMP","Andrew Ronald Post","Jared P Rutter","Jennifer Anne Doherty"],"agency_ic":"NCI","activity_code":"P30","fiscal_years":[2025,2026],"award_amount_usd":8898241,"org_name":"UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=P30CA042014","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-18T02:48:44.992046Z","snippet":null,"locator":"PMID 35868306 reported under P30CA042014","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"K99CA237630","project_num":null,"title":"Characterizing the pathogenesis and targeted therapeutics of Wilms' Tumor 1 (WT1) mutations in AML","pi_names":["Haijiao Zhang"],"agency_ic":"CA","activity_code":"K99","fiscal_years":[2019,2020],"award_amount_usd":204284,"org_name":"OREGON HEALTH & SCIENCE UNIVERSITY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=K99CA237630","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-18T02:48:44.992046Z","snippet":null,"locator":"PMID 35868306 reported under K99CA237630","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"K08CA245224","project_num":null,"title":"Epigenetics of Mutation-Order in Acute Myeloid Leukemia","pi_names":["Theodore Paul Braun"],"agency_ic":"NCI","activity_code":"K08","fiscal_years":[2020,2021,2022,2023,2024],"award_amount_usd":812255,"org_name":"OREGON HEALTH & SCIENCE UNIVERSITY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=K08CA245224","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-18T02:48:44.992046Z","snippet":null,"locator":"PMID 35868306 reported under K08CA245224","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]},{"core_project_num":"F30CA239335","project_num":null,"title":"Defining the stromal landscape that sustains AML drug resistance","pi_names":["Sunil Kumar Joshi"],"agency_ic":"NCI","activity_code":"F30","fiscal_years":[2019,2020,2021,2022],"award_amount_usd":187070,"org_name":"OREGON HEALTH & SCIENCE UNIVERSITY","reporter_url":"https://reporter.nih.gov/search/results?text_criteria=F30CA239335","role":"generation","evidence":[{"method":"api","source_url":"https://api.reporter.nih.gov/v2/publications/search","source_label":"NIH RePORTER","retrieved_at":"2026-09-18T02:48:44.992046Z","snippet":null,"locator":"PMID 35868306 reported under F30CA239335","confidence":"high","reviewer":null,"reviewed_at":null,"note":"Funding role inferred from whether the award appears on the dataset's own publication or on a downstream study."}]}],"access_steps":[{"order":1,"action":"Open the study in cBioPortal","detail":"Harmonized molecular and clinical files are open. Cite the original publication, and cite cBioPortal if the portal's harmonized files were used.","url":"https://www.cbioportal.org/study/summary?id=aml_ohsu_2022","requires":[],"est_time":"5 minutes","cli_snippet":null,"audience":"human","evidence":[{"method":"derived","source_url":"https://www.cbioportal.org/study/summary?id=aml_ohsu_2022","source_label":"cBioPortal access documentation","retrieved_at":"2026-09-21T12:30:59.429188Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]},{"order":2,"action":"Download the whole study as a zip","detail":"The datasets page carries the staging files used by the portal.","url":"https://www.cbioportal.org/datasets","requires":[],"est_time":"minutes","cli_snippet":null,"audience":"human","evidence":[{"method":"derived","source_url":"https://www.cbioportal.org/datasets","source_label":"cBioPortal access documentation","retrieved_at":"2026-09-21T12:30:59.429190Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]},{"order":3,"action":"Or pull the staging files with git-lfs","detail":"Study folders are named by study id under public/.","url":"https://github.com/cBioPortal/datahub","requires":[],"est_time":null,"cli_snippet":"git clone https://github.com/cBioPortal/datahub.git && cd datahub\ngit -c lfs.fetchexclude=\"\" lfs pull -I public/aml_ohsu_2022","audience":"human","evidence":[{"method":"derived","source_url":"https://github.com/cBioPortal/datahub","source_label":"cBioPortal access documentation","retrieved_at":"2026-09-21T12:30:59.429192Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]},{"order":4,"action":"Read the study straight from the REST API","detail":"No key is required; pace requests when sweeping many studies.","url":"https://docs.cbioportal.org/web-api-and-clients/","requires":[],"est_time":null,"cli_snippet":"curl -s 'https://www.cbioportal.org/api/studies/aml_ohsu_2022/clinical-data?clinicalDataType=PATIENT&projection=SUMMARY'","audience":"agent","evidence":[{"method":"derived","source_url":"https://docs.cbioportal.org/web-api-and-clients/","source_label":"cBioPortal access documentation","retrieved_at":"2026-09-21T12:30:59.429195Z","snippet":null,"locator":null,"confidence":"medium","reviewer":null,"reviewed_at":null,"note":"Generated by applying the repository's documented access policy to this dataset's identifiers. It is not a reviewer's account of this dataset."}]}],"analysis_examples":[],"agent_package":{"json_url":"/data/datasets/cbio-aml-ohsu-2022.json","jsonld_url":"/data/jsonld/cbio-aml-ohsu-2022.jsonld","croissant_url":"/data/croissant/cbio-aml-ohsu-2022.json","instructions_url":"/data/agent/cbio-aml-ohsu-2022.md","bundle_url":null,"mcp_resource_uri":null},"related_dataset_ids":[],"related_underexplored_ids":[],"review":{"status":"machine_only","reviewer":null,"reviewer_affiliation":null,"reviewed_at":null,"sections_reviewed":[],"open_questions":[],"notes":null},"verification":{"last_verified_at":null,"link_checks":[],"n_links_ok":0,"n_links_broken":0,"upstream_version_seen":null,"upstream_version_changed":false,"upstream_counts_seen":{},"upstream_drift":{},"notes":[]},"is_showcase":false,"completeness_score":35.7,"tags":["cbioportal","investigator-cohort","harmonized-for-reuse","nci-funded"],"search_text":null}